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CAZyme Information: MGYG000002082_00719

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Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Alistipes sp900544265
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes sp900544265
CAZyme ID MGYG000002082_00719
CAZy Family GH38
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
863 MGYG000002082_3|CGC3 96199.33 6.6261
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002082 2573115 MAG Netherlands Europe
Gene Location Start: 174322;  End: 176913  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002082_00719.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH38 59 204 1.2e-29 0.5278810408921933

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG0383 AMS1 3.12e-20 119 863 286 943
Alpha-mannosidase [Carbohydrate transport and metabolism].
pfam07748 Glyco_hydro_38C 1.12e-11 502 707 1 182
Glycosyl hydrolases family 38 C-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism.
PRK09819 PRK09819 3.73e-11 459 829 452 847
mannosylglycerate hydrolase.
cd10789 GH38N_AMII_ER_cytosolic 1.48e-10 60 201 32 169
N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38). The subfamily is represented by Saccharomyces cerevisiae vacuolar alpha-mannosidase Ams1, rat ER/cytosolic alpha-mannosidase Man2C1, and similar proteins. Members in this family share high sequence similarity. None of them have any classical signal sequence or membrane spanning domains, which are typical of sorting or targeting signals. Ams1 functions as a second resident vacuolar hydrolase in S. cerevisiae. It aids in recycling macromolecular components of the cell through hydrolysis of terminal, non-reducing alpha-d-mannose residues. Ams1 utilizes both the cytoplasm to vacuole targeting (Cvt, nutrient-rich conditions) and autophagic (starvation conditions) pathways for biosynthetic delivery to the vacuole. Man2C1is involved in oligosaccharide catabolism in both the ER and cytosol. It can catalyze the cobalt-dependent cleavage of alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues. Members in this family are retaining glycosyl hydrolases of family GH38 that employs a two-step mechanism involving the formation of a covalent glycosyl-enzyme complex. Two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst.
pfam01074 Glyco_hydro_38 3.81e-10 60 169 32 140
Glycosyl hydrolases family 38 N-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BBL11622.1 0.0 2 863 24 883
BBL08830.1 0.0 2 863 24 883
BBL00893.1 0.0 2 863 24 882
BBL06663.1 0.0 16 863 34 880
QUR41760.1 0.0 22 862 7 852

PDB Hits      help

has no PDB hit.

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9NTJ4 1.16e-10 55 820 280 994
Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1
Q91W89 5.25e-09 55 820 279 993
Alpha-mannosidase 2C1 OS=Mus musculus OX=10090 GN=Man2c1 PE=1 SV=1
P21139 1.60e-06 55 820 279 994
Alpha-mannosidase 2C1 OS=Rattus norvegicus OX=10116 GN=Man2c1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

0.000407 0.998830 0.000241 0.000193 0.000165 0.000147

TMHMM  Annotations      download full data without filtering help

start end
13 32