CAZyme Information: MGYG000002097_01480

Basic Information

• Species: Firm-11 sp900553905
• Lineage: Bacteria; Firmicutes_A; Clostridia_A; Christensenellales; CAG-74; Firm-11; Firm-11 sp900553905
• CAZyme ID: MGYG000002097_01480
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
932		101990.05	4.4416

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002097	2742547	MAG	Mongolia	Asia

• Gene Location: Start: 7044; End: 9842 Strand: +

Full Sequence      

MYHSNEPYDGHQQPYDPNGGDSFEGSWENDPAYRPPEEEDAPRKRTIFKPRLTKPNFVLS
VLVNAVRLTALLIVLCGLALAGAVAGIAKGYMETAPTLDLALLDDQDKTSFLYDAQGNVI
TDYKGTENRIMVNISLMPEELRNAFVAVEDARFYTHNGIDIKRIIGSFIQNFISGTQQGG
STITQQLIKNTVLSSELSYKRKIQEAYLAMQLETKYTKLQILEYYLNTIYLGENYYGVQV
AAQGYFGKELSELTLRECAMLAGVTTNPYYYNPRRNFYTRTSDTTDYKAITNDRTDYVLR
CMYENEFITQQQYQEALDPSTAHVLETSTTEGDGMYPYAHYVEYAVQDIVDCFLELNGLE
DTSENRSKMENELRTGGYHVTLAIDTEIQEIVEDTLENWDSYPALRDPSDKVYRTLNYDG
TYDEIVQPQAAAVVLDYRTGELKAIVGSRTRPTARKTLNRATDMEMPVGSAIKPIAVYAP
ALEMGYSPASIVYNIPVPITGWTGSDGKDTWPQNYGGSDYVGPETLRNGMKRSHNVAAAQ
TLLTMVGVDRSVDFLLRMGVDRDNIDATPFGLSLGSSGITPVQLAVAFGVLGNGGVYQEP
ISFLGISDSAGNVVYDSHAQQERRQVFRPSTAWMIVDMMKDVVSGGTATAAKISGQTVAG
KTGTNSDQRGVTFVGMTGWYVSSIWVGHDNYKPLSSKTTGSSGALPIWKSYMTKIHEAKG
LEDRDIIEANPEDLGLVKVTTCAVSGQLATEACYNDSKGYGVVTDYWYEPTVPTVSCQMH
QSVVTCTQTGMLATEYCPSTTTTGVVVIPNGHPLSVYANDSQYGPVIAEYLGTASNLGYC
TLHTSYETSTGGGWADGGWTDSSTENSLVPDARQLLQSAYDLMGSMDASSQAYANIQSAA
ASLENILSSGNPGMADVAGGMALLTQAMASAY

Enzyme Prediction     

No EC number prediction in MGYG000002097_01480.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	117	302	4.8e-63	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	2.50e-176	128	717	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	3.88e-161	66	738	12	619	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	3.57e-140	71	781	9	772	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.26e-103	127	716	145	683	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	5.27e-75	116	303	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QTE72383.1	0.0	45	932	99	992
QTE73372.1	0.0	45	932	99	992
QUC66968.1	0.0	45	932	99	997
QUA52775.1	0.0	24	932	67	990
QTE69475.1	0.0	35	932	69	960

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	1.68e-67	92	774	2	808	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	1.17e-65	112	749	23	750	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.66e-57	112	712	23	712	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5U2G_A	5.04e-51	88	615	3	564	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	1.27e-50	127	712	154	690	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q0TNZ8	3.52e-102	92	783	54	727	Penicillin-binding protein 1A OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=pbpA PE=3 SV=1
Q0SRL7	5.51e-100	92	780	54	724	Penicillin-binding protein 1A OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=pbpA PE=3 SV=1
A7FY32	2.49e-95	86	823	33	745	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	2.49e-95	86	823	33	745	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1
Q8XJ01	4.18e-95	92	717	54	667	Penicillin-binding protein 1A OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999949	0.000037	0.000004	0.000000	0.000000	0.000003

TMHMM  Annotations     

start	end
66	88