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CAZyme Information: MGYG000002108_00601

You are here: Home > Sequence: MGYG000002108_00601

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Prevotella sp900290275
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Prevotella; Prevotella sp900290275
CAZyme ID MGYG000002108_00601
CAZy Family GH89
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
722 MGYG000002108_12|CGC1 83260.86 7.0847
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002108 2842572 MAG Mongolia Asia
Gene Location Start: 7133;  End: 9301  Strand: +

Full Sequence      Download help

MKQNRTLLTV  FLFLMSLGLF  AATPIEGLLE  RIDKGASRKI  LTETVRSDRD  FFEITSRDGK60
PLVRGNNYVS  IASGINWYLK  YSVGVHLTWN  SMHATLPATL  PLVQGVERHT  TDIKHRYYLN120
YCTLSYSMAF  WDWKRWEQEL  DWMALHGINL  CLDIVGTDVV  WRNVLLKLGY  SKDEANQFIA180
GPGFQAWWLM  NNLEGWGGPN  SDNWYKQRER  LQKQIMKRMK  ELGINVCLPG  YSGMVPHDAK240
QRLGLDVADP  GKWNDYKRPA  FLLPTDKRFA  EIAAIYYKEM  QKLYGKADYY  SMDPFHEGGN300
PRGVDLGKAG  EAIMVAMKAA  NPKAVWVAQA  WGACPYPAMI  KHLKNGDMLV  LDLYSETRPQ360
WGDPESTWLR  KDGFNGHDWA  FCMLLNFGGN  VGLYGKLQHV  VDEYYKARQS  KFASTLKGVG420
LTMEGIENNP  IMYELVSELP  WRNNKFGWQE  WLNSYVEARY  GNINNTKVHD  AWMLLARSVY480
GASDKVLEQG  CHESVLCARP  ALDVYQVSSW  SEMEEFYNPD  DVIRAARLMV  EASHEVKANA540
NFRYDLIDIT  RQAIAEQARY  VYAEIVAAYK  AKDRKMFDYT  TKHFLDILLQ  QDRMLSSMPD600
FMVGGWIRSA  RNLGTNAQES  DHYEWNARVQ  ITTWGNRNAA  EKGGLREYAH  KEWNGVLADF660
YYPRWKAYFE  ALAATFDGKP  MKNIDFYAMD  EEWTLKHNAY  PYEAQGDAVE  FAQKAFEEVF720
KK722

Enzyme Prediction      help

No EC number prediction in MGYG000002108_00601.

CAZyme Signature Domains help

Created with Snap367210814418021625228832436139743346950554157761364968559717GH89
Family Start End Evalue family coverage
GH89 59 717 1.1e-243 0.9939668174962293

CDD Domains      download full data without filtering help

Created with Snap3672108144180216252288324361397433469505541577613649685116443NAGLU451713NAGLU_C23101NAGLU_N
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam05089 NAGLU 0.0 116 443 1 333
Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.
pfam12972 NAGLU_C 9.47e-98 451 713 1 258
Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold.
pfam12971 NAGLU_N 2.41e-27 23 101 1 81
Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold.

CAZyme Hits      help

Created with Snap367210814418021625228832436139743346950554157761364968512722ADV42401.1|GH893719QRO24616.1|GH8912722QUT50280.1|GH891719QRP91352.1|GH891719QCQ40346.1|GH89
Hit ID E-Value Query Start Query End Hit Start Hit End
ADV42401.1 0.0 12 722 9 718
QRO24616.1 0.0 3 719 1 715
QUT50280.1 0.0 12 722 9 718
QRP91352.1 0.0 1 719 1 717
QCQ40346.1 0.0 1 719 1 717

PDB Hits      download full data without filtering help

Created with Snap3672108144180216252288324361397433469505541577613649685507172VC9_A507177MFK_A507174A4A_A637164XWH_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2VC9_A 1.16e-144 50 717 202 875
Family89 Glycoside Hydrolase from Clostridium perfringens in complex with 2-acetamido-1,2-dideoxynojirmycin [Clostridium perfringens],2VCA_A Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine [Clostridium perfringens],2VCB_A Family 89 Glycoside Hydrolase from Clostridium perfringens in complex with PUGNAc [Clostridium perfringens],2VCC_A Family 89 Glycoside Hydrolase from Clostridium perfringens [Clostridium perfringens]
7MFK_A 1.43e-144 50 717 210 883
ChainA, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124],7MFL_A Chain A, Alpha-N-acetylglucosaminidase family protein [Clostridium perfringens ATCC 13124]
4A4A_A 1.62e-143 50 717 225 898
CpGH89(E483Q, E601Q), from Clostridium perfringens, in complex with its substrate GlcNAc-alpha-1,4-galactose [Clostridium perfringens]
4XWH_A 3.64e-125 63 716 54 708
Crystalstructure of the human N-acetyl-alpha-glucosaminidase [Homo sapiens]

Swiss-Prot Hits      download full data without filtering help

Created with Snap367210814418021625228832436139743346950554157761364968526720sp|Q9FNA3|NAGLU_ARATH63716sp|P54802|ANAG_HUMAN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9FNA3 3.34e-129 26 720 50 805
Alpha-N-acetylglucosaminidase OS=Arabidopsis thaliana OX=3702 GN=NAGLU PE=2 SV=1
P54802 3.70e-124 63 716 77 731
Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.004237 0.994398 0.000729 0.000210 0.000206 0.000213

TMHMM  Annotations      download full data without filtering help

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