Species | Methanobrevibacter_A oralis | |||||||||||
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Lineage | Archaea; Methanobacteriota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanobrevibacter_A; Methanobrevibacter_A oralis | |||||||||||
CAZyme ID | MGYG000002162_00057 | |||||||||||
CAZy Family | GT4 | |||||||||||
CAZyme Description | D-inositol-3-phosphate glycosyltransferase | |||||||||||
CAZyme Property |
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Genome Property |
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Gene Location | Start: 49433; End: 49765 Strand: - |
Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
---|---|---|---|---|---|---|---|
cd03801 | GT4_PimA-like | 1.64e-29 | 3 | 98 | 252 | 350 | phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. |
cd03808 | GT4_CapM-like | 3.01e-28 | 3 | 100 | 250 | 349 | capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides. |
pfam00534 | Glycos_transf_1 | 1.89e-27 | 2 | 95 | 62 | 158 | Glycosyl transferases group 1. Mutations in this domain of PIGA lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. |
pfam13692 | Glyco_trans_1_4 | 1.52e-26 | 3 | 81 | 60 | 138 | Glycosyl transferases group 1. |
cd03814 | GT4-like | 3.31e-25 | 3 | 100 | 252 | 352 | glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes. |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
---|---|---|---|---|---|
AMD17947.1 | 2.15e-51 | 1 | 110 | 251 | 360 |
ALT69529.1 | 4.14e-47 | 3 | 110 | 249 | 356 |
ADC47529.1 | 1.19e-45 | 3 | 110 | 261 | 368 |
AMK15704.1 | 7.04e-45 | 3 | 109 | 264 | 370 |
ATZ60035.1 | 8.41e-44 | 3 | 110 | 252 | 359 |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
6ME2_A | 5.32e-13 | 6 | 102 | 310 | 407 | XFELcrystal structure of human melatonin receptor MT1 in complex with ramelteon [Homo sapiens] |
6ME3_A | 5.32e-13 | 6 | 102 | 310 | 407 | XFELcrystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin [Homo sapiens],6ME4_A XFEL crystal structure of human melatonin receptor MT1 in complex with 2-iodomelatonin [Homo sapiens],6ME5_A XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine [Homo sapiens],6PS8_A XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin. [Homo sapiens] |
6V9S_A | 7.35e-13 | 6 | 101 | 355 | 451 | Structure-baseddevelopment of subtype-selective orexin 1 receptor antagonists [Homo sapiens] |
4ZJ8_A | 7.35e-13 | 6 | 101 | 355 | 451 | Structuresof the human OX1 orexin receptor bound to selective and dual antagonists [Homo sapiens],4ZJC_A Structures of the human OX1 orexin receptor bound to selective and dual antagonists [Homo sapiens] |
5WQC_A | 7.36e-13 | 6 | 101 | 362 | 458 | Crystalstructure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8. [Homo sapiens],5WS3_A Crystal structures of human orexin 2 receptor bound to the selective antagonist EMPA determined by serial femtosecond crystallography at SACLA [Homo sapiens] |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
Q58577 | 2.16e-14 | 8 | 100 | 241 | 334 | Uncharacterized glycosyltransferase MJ1178 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) OX=243232 GN=MJ1178 PE=3 SV=1 |
A1R8N8 | 1.49e-12 | 16 | 99 | 299 | 383 | D-inositol 3-phosphate glycosyltransferase OS=Paenarthrobacter aurescens (strain TC1) OX=290340 GN=mshA PE=3 SV=1 |
Q0P9C9 | 1.95e-12 | 3 | 101 | 259 | 358 | N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase OS=Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) OX=192222 GN=pglA PE=1 SV=1 |
C7MSY6 | 3.87e-12 | 8 | 100 | 310 | 403 | D-inositol 3-phosphate glycosyltransferase OS=Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101) OX=471857 GN=mshA PE=3 SV=1 |
D5USX8 | 7.24e-12 | 18 | 100 | 318 | 401 | D-inositol 3-phosphate glycosyltransferase OS=Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / CCUG 35730 / CIP 100753 / JCM 10117 / KCTC 9821 / NBRC 16120 / NCIMB 702349 / NCTC 13040) OX=521096 GN=mshA PE=3 SV=1 |
Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
---|---|---|---|---|---|
1.000030 | 0.000019 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
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