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CAZyme Information: MGYG000002221_00135
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; UMGS1889; | |||||||||||
| CAZyme ID | MGYG000002221_00135 | |||||||||||
| CAZy Family | GH74 | |||||||||||
| CAZyme Description | Xyloglucanase Xgh74A | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 4339; End: 6567 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH74 | 203 | 392 | 1.8e-44 | 0.8025751072961373 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam15902 | Sortilin-Vps10 | 8.22e-06 | 506 | 715 | 1 | 178 | Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1. |
| pfam15902 | Sortilin-Vps10 | 1.07e-04 | 153 | 270 | 3 | 112 | Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1. |
| pfam15902 | Sortilin-Vps10 | 1.80e-04 | 98 | 222 | 4 | 115 | Sortilin, neurotensin receptor 3,. Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1. |
| smart00602 | VPS10 | 0.001 | 253 | 711 | 8 | 404 | VPS10 domain. |
| cd15482 | Sialidase_non-viral | 0.003 | 508 | 641 | 176 | 325 | Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CBK97166.1 | 4.24e-256 | 61 | 741 | 59 | 747 |
| CBL33465.1 | 3.80e-255 | 61 | 741 | 62 | 750 |
| AHM63515.1 | 4.01e-181 | 61 | 736 | 49 | 731 |
| QPI49975.1 | 3.19e-178 | 51 | 735 | 19 | 715 |
| QSB28812.1 | 9.33e-177 | 68 | 738 | 27 | 706 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6P2L_A | 1.04e-152 | 64 | 734 | 7 | 681 | Crystalstructure of Niastella koreensis GH74 (NkGH74) enzyme [Niastella koreensis GR20-10] |
| 6P2M_A | 1.00e-114 | 63 | 736 | 10 | 690 | ChainA, Type 3a cellulose-binding domain protein [Caldicellulosiruptor lactoaceticus 6A] |
| 1SQJ_A | 1.62e-105 | 63 | 742 | 4 | 765 | CrystalStructure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH) [Geotrichum sp. M128],1SQJ_B Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH) [Geotrichum sp. M128] |
| 2EBS_A | 8.65e-105 | 63 | 742 | 4 | 765 | ChainA, Oligoxyloglucan reducing end-specific cellobiohydrolase [Geotrichum sp. M128],2EBS_B Chain B, Oligoxyloglucan reducing end-specific cellobiohydrolase [Geotrichum sp. M128] |
| 7KN8_A | 3.04e-104 | 68 | 738 | 15 | 713 | ChainA, Cellulase [Xanthomonas campestris pv. campestris str. ATCC 33913],7KN8_B Chain B, Cellulase [Xanthomonas campestris pv. campestris str. ATCC 33913] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q8J0D2 | 1.50e-104 | 63 | 742 | 27 | 788 | Oligoxyloglucan reducing end-specific cellobiohydrolase OS=Geotrichum sp. (strain M128) OX=203496 PE=1 SV=1 |
| A3DFA0 | 1.32e-97 | 71 | 736 | 47 | 755 | Xyloglucanase Xgh74A OS=Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) OX=203119 GN=xghA PE=3 SV=1 |
| Q70DK5 | 4.99e-97 | 71 | 736 | 47 | 755 | Xyloglucanase Xgh74A OS=Acetivibrio thermocellus OX=1515 GN=xghA PE=1 SV=1 |
| Q3MUH7 | 5.45e-97 | 63 | 741 | 38 | 768 | Xyloglucanase OS=Paenibacillus sp. OX=58172 GN=xeg74 PE=1 SV=1 |
| Q5BD38 | 1.97e-94 | 59 | 738 | 31 | 807 | Oligoxyloglucan-reducing end-specific xyloglucanase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=xgcA PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000000 | 0.000002 | 1.000057 | 0.000000 | 0.000000 | 0.000000 |