dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002281_00184

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Basic Information help

Species

Bacteroides faecis

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides faecis

CAZyme ID

MGYG000002281_00184

CAZy Family

GH38

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
849		97136.06	6.9809

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002281	6145961	Isolate	China	Asia

Gene Location

Start: 236564; End: 239113 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002281_00184.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH38	12	265	2.4e-33	0.9219330855018587

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0383	AMS1	1.55e-23	84	848	273	943	Alpha-mannosidase [Carbohydrate transport and metabolism].
pfam01074	Glyco_hydro_38	1.32e-14	46	189	32	172	Glycosyl hydrolases family 38 N-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism.
PRK09819	PRK09819	7.92e-14	387	826	376	859	mannosylglycerate hydrolase.
cd10789	GH38N_AMII_ER_cytosolic	7.96e-12	46	189	32	171	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38). The subfamily is represented by Saccharomyces cerevisiae vacuolar alpha-mannosidase Ams1, rat ER/cytosolic alpha-mannosidase Man2C1, and similar proteins. Members in this family share high sequence similarity. None of them have any classical signal sequence or membrane spanning domains, which are typical of sorting or targeting signals. Ams1 functions as a second resident vacuolar hydrolase in S. cerevisiae. It aids in recycling macromolecular components of the cell through hydrolysis of terminal, non-reducing alpha-d-mannose residues. Ams1 utilizes both the cytoplasm to vacuole targeting (Cvt, nutrient-rich conditions) and autophagic (starvation conditions) pathways for biosynthetic delivery to the vacuole. Man2C1is involved in oligosaccharide catabolism in both the ER and cytosol. It can catalyze the cobalt-dependent cleavage of alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues. Members in this family are retaining glycosyl hydrolases of family GH38 that employs a two-step mechanism involving the formation of a covalent glycosyl-enzyme complex. Two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst.
smart00872	Alpha-mann_mid	6.91e-09	297	344	14	62	Alpha mannosidase, middle domain. Members of this entry belong to the glycosyl hydrolase family 38, This domain, which is found in the central region adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
QQA07855.1	1	849	1	849
QUT69752.1	1	849	1	849
AAO79177.1	1	849	1	849
QMW86426.1	1	849	1	849
ALJ43681.1	1	849	1	849

PDB Hits help

has no PDB hit.

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q54K67	1.15e-10	75	844	315	1082	Alpha-mannosidase G OS=Dictyostelium discoideum OX=44689 GN=manG PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000196	0.999209	0.000150	0.000138	0.000133	0.000129

TMHMM Annotations help

There is no transmembrane helices in MGYG000002281_00184.