CAZyme Information: MGYG000002282_01805

Basic Information

• Species: Parabacteroides gordonii
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae; Parabacteroides; Parabacteroides gordonii
• CAZyme ID: MGYG000002282_01805
• CAZy Family: GH33
• CAZyme Description: Sialidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
373	MGYG000002282_4|CGC3	41252.45	5.479

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002282	6348794	Isolate	China	Asia

• Gene Location: Start: 127227; End: 128348 Strand: +

Full Sequence      

MIATCSILLMLLSISLQAQENPTTDVFQKGQDGYACFRIPAIVRSKAGTLLAFAEARRNS
CSDTGNIDLVVKRSEDGGKTWSKAITVWDDGDNVCGNPAPIVDQETGRIILVTCWNLGED
HEKEIIDGKSKDSRCIYVLSSDNDGISWSAPKEISSSVKHPDWTWYATGPCHGIQLQSKK
YKGRLVVSANHMVAGTKTYHSQLIYSDDKGETWKLGGIVSKHGGNESSVVELENGNLMLN
MRNYNREESKSRSYVISEDGGETVSEMQYLPELIEPICQGSTLNYMKNGKISNNILFSNP
ASTDKREKMTIKLSENNGKTWPYAFPVYSGPSAYSDLVNLPDGNIGLLYEYGTDNAYEKI
GFTCISFETLKKL

Enzyme Prediction     

No EC number prediction in MGYG000002282_01805.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH33	23	364	1.5e-103	0.9736842105263158

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd15482	Sialidase_non-viral	6.83e-121	24	366	1	339	Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam13088	BNR_2	5.94e-35	48	347	1	280	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
COG4409	NanH	9.00e-18	18	357	255	707	Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
pfam13859	BNR_3	2.35e-15	48	242	9	193	BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
cd00260	Sialidase	2.47e-09	33	215	11	184	sialidases/neuraminidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed beta-propeller fold. This hierarchy includes eubacterial, eukaryotic, and viral sialidases.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AYQ36531.1	1.91e-137	10	368	13	368
CAZ95099.1	7.96e-136	12	368	20	378
ASO04237.1	1.72e-132	26	370	42	383
QEC45250.1	6.32e-123	26	372	98	440
BBD46002.1	1.98e-121	25	371	38	376

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6MNJ_A	1.77e-41	30	350	193	521	Hadzamicrobial sialidase Hz136 [Alistipes],6MNJ_B Hadza microbial sialidase Hz136 [Alistipes]
6MYV_A	6.62e-41	30	350	174	504	Sialidase26co-crystallized with DANA-Gc [bacterium],6MYV_B Sialidase26 co-crystallized with DANA-Gc [bacterium],6MYV_C Sialidase26 co-crystallized with DANA-Gc [bacterium],6MYV_D Sialidase26 co-crystallized with DANA-Gc [bacterium]
6MRV_A	9.34e-41	30	350	195	525	Sialidase26co-crystallized with DANA [bacterium],6MRV_B Sialidase26 co-crystallized with DANA [bacterium],6MRX_A Sialidase26 apo [bacterium],6MRX_B Sialidase26 apo [bacterium],6MRX_C Sialidase26 apo [bacterium],6MRX_D Sialidase26 apo [bacterium]
4FJ6_A	5.91e-39	26	350	170	504	Crystalstructure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution [Parabacteroides distasonis ATCC 8503],4FJ6_B Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution [Parabacteroides distasonis ATCC 8503],4FJ6_C Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution [Parabacteroides distasonis ATCC 8503],4FJ6_D Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution [Parabacteroides distasonis ATCC 8503]
1EUR_A	8.44e-38	25	357	13	351	Sialidase[Micromonospora viridifaciens],1EUS_A Sialidase Complexed With 2-Deoxy-2,3-Dehydro-N- Acetylneuraminic Acid [Micromonospora viridifaciens]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O35657	7.59e-36	37	366	71	404	Sialidase-1 OS=Mus musculus OX=10090 GN=Neu1 PE=1 SV=1
P31206	9.63e-36	30	350	196	526	Sialidase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=nanH PE=3 SV=2
Q99PW3	1.05e-35	37	366	71	404	Sialidase-1 OS=Rattus norvegicus OX=10116 GN=Neu1 PE=1 SV=1
Q02834	1.61e-35	25	357	55	393	Sialidase OS=Micromonospora viridifaciens OX=1881 GN=nedA PE=1 SV=1
A5PF10	3.16e-35	37	366	78	411	Sialidase-1 OS=Sus scrofa OX=9823 GN=NEU1 PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000268	0.999091	0.000159	0.000163	0.000145	0.000138

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002282_01805.