CAZyme Information: MGYG000002307_01106

Basic Information

• Species: Campylobacter hyointestinalis
• Lineage: Bacteria; Campylobacterota; Campylobacteria; Campylobacterales; Campylobacteraceae; Campylobacter; Campylobacter hyointestinalis
• CAZyme ID: MGYG000002307_01106
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
643		72554.9	5.8589

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002307	1753385	Isolate	Belgium	Europe

• Gene Location: Start: 1042803; End: 1044734 Strand: +

Full Sequence      

MKHIFSFFTIIAICLLVGFVYFYSQIRVDISTIVDYKPKLTTQIFDRNGNLVANIFDEEN
RQYAQYDEIPQRVIESLVAIEDTSFFEHGGINVEAIFRAAIKDIKAMALVEGASTLTQQL
IKNMVLTRDKKFTRKLREIILAIKIEDELTKEQIIERYLNQVYFGHGYYGIKTAALGYFK
KNLNELSLKEIAMLVGLPKAPSNYDPTRHMDLSISRANGVISRLFNLGWITQDEYEASLK
ETPMVFDETLTQNRAPYLVDEAIKEAIKQYPDIKYGGYKVTLTADLKIQSIAQNALKFGY
TEILKRDKNADETYLNGAIIVTNPTNGEILALVGGVDYAKSNFNRATQSERQPGSSFKPF
IYQIALDLGYSPMSKVADISRVFENAGRNEEDKDWKPKNYGGNFEGYITLKDALRQSRNL
ATINLLNSIGLDIVSQKLSNFGFKNIPQNLSIALGSFGISLIEFSEHYSMFAGLGTTSKS
NLIKSIQKDEVITEFSSEQTVMIKPEQAYLMIDMLKTVVEEGTGRGAKVAGIEIAGKTGT
TNNNIDAWFCGFTPEVQAIIWYGNDNNMPMRKIEGGGRTAAPVFREFIQNYIKEFPDTKR
KFDTPKEVYHKIYEGNDAIYTDTSPLPKQQINAIDMQEGGLIF

Enzyme Prediction     

No EC number prediction in MGYG000002307_01106.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	49	224	2.6e-63	0.9830508474576272

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG5009	MrcA	0.0	1	608	2	733	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	0.0	60	593	1	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	1	605	15	610	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
PRK11636	mrcA	2.67e-102	1	589	1	782	penicillin-binding protein 1a; Provisional
COG4953	PbpC	1.29e-95	11	588	14	558	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ANE32746.1	0.0	1	643	1	643
QKF55916.1	0.0	1	643	1	643
QCU00121.1	0.0	1	643	1	643
QKF69368.1	0.0	1	643	1	643
ANE34441.1	0.0	1	643	1	643

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	2.58e-90	30	596	9	727	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	8.40e-84	43	596	22	720	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
5FGZ_A	3.20e-72	38	590	142	692	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	4.56e-72	38	590	163	713	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
5U2G_A	6.41e-70	29	611	9	775	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O66874	3.51e-107	11	607	11	681	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
O87626	1.57e-104	29	588	37	701	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
P0A0Z5	8.81e-96	29	593	37	707	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1
P0A0Z6	8.81e-96	29	593	37	707	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup B (strain MC58) OX=122586 GN=mrcA PE=3 SV=1
O87579	4.69e-95	29	596	37	710	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.997050	0.002573	0.000290	0.000016	0.000009	0.000100

TMHMM  Annotations     

start	end
5	24