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CAZyme Information: MGYG000002311_01423

You are here: Home > Sequence: MGYG000002311_01423

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Vibrio cholerae
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Vibrionaceae; Vibrio; Vibrio cholerae
CAZyme ID MGYG000002311_01423
CAZy Family GH33
CAZyme Description Sialidase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
781 MGYG000002311_1|CGC16 85609.25 4.6883
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002311 4089020 Isolate Haiti North America
Gene Location Start: 1612595;  End: 1614940  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.18

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH33 218 768 8.4e-114 0.97953216374269

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4409 NanH 0.0 1 781 27 725
Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
pfam09264 Sial-lect-inser 8.99e-107 347 543 1 198
Vibrio cholerae sialidase, lectin insertion. Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme.
cd15482 Sialidase_non-viral 9.27e-32 546 761 145 328
Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam09264 Sial-lect-inser 3.44e-16 65 215 10 155
Vibrio cholerae sialidase, lectin insertion. Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme.
pfam13088 BNR_2 1.75e-11 546 745 109 272
BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QTV01065.1 0.0 1 781 1 781
QHA21694.1 0.0 1 781 27 807
AVK79103.1 0.0 1 781 23 803
ARB80595.1 0.0 1 781 27 807
AVK79105.1 0.0 1 781 23 803

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1KIT_A 0.0 25 781 1 757
VibrioCholerae Neuraminidase [Vibrio cholerae],6EKS_A Vibrio cholerae neuraminidase complexed with oseltamivir carboxylate [Vibrio cholerae O1 biovar El Tor str. N16961],6EKU_A Vibrio cholerae neuraminidase complexed with zanamivir [Vibrio cholerae O1 biovar El Tor str. N16961]
1W0O_A 0.0 1 781 1 781
Vibriocholerae sialidase [Vibrio cholerae],1W0P_A Vibrio cholerae sialidase with alpha-2,6-sialyllactose [Vibrio cholerae]
2W68_A 2.73e-133 25 216 4 195
EnhancingThe Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae],2W68_B Enhancing The Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae],2W68_C Enhancing The Receptor Affinity Of The Sialic Acid-Binding Domain Of Vibrio Cholerae Sialidase Through Multivalency [Vibrio cholerae]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
A5F7A4 0.0 1 781 1 781
Sialidase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) OX=345073 GN=nanH PE=1 SV=2
P0C6E9 0.0 1 781 1 781
Sialidase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=nanH PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000303 0.998905 0.000193 0.000228 0.000188 0.000168

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002311_01423.