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CAZyme Information: MGYG000002312_02519

You are here: Home > Sequence: MGYG000002312_02519

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Blautia_A sp000285855
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Blautia_A; Blautia_A sp000285855
CAZyme ID MGYG000002312_02519
CAZy Family GH36
CAZyme Description Bifunctional alpha-galactosidase/sucrose kinase AgaSK
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
733 MGYG000002312_49|CGC2 84057.64 5.295
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002312 4168980 Isolate France Europe
Gene Location Start: 99580;  End: 101781  Strand: -

Full Sequence      Download help

MEWIKYHEAE  KVFDLRTEHS  TYQMQVREYD  TLVHLYYGSP  VGDALITDRI  VCVDRGFSGN60
PYEAEKDKTF  SLDTLPQEYT  TYGNGDYRIN  GLETEQADGS  DTANLKFESY  EITKGKYSLK120
GLPAMFAKED  EAETLEIVLT  DRASGLKAHL  LYGVFPHLDV  ITRAVRLENT  GTAPVTVKKA180
MSMEMDYEYR  ELDVVHFYGR  HNVERQMERT  HLGHGNWSVG  SIRGTSSHHH  NPFVILCDRN240
TEETYGNCYG  YALAYSGNFL  FETEVDQVGH  TRVAMGIHPY  HFSWTLEQGD  SFETPEVIMA300
YSAEGFGKLS  RIYHDAYRSN  LIRSKYTEQP  RPILVNNWEA  TYFDFDADKI  YHIAEEAKNI360
GLDMFVLDDG  WFGKRDNDWC  ALGDWEVNEE  KIKGGLPALA  EKIHGLGLKF  GLWVEPEMIS420
EDSDLYREHP  DWALKIPGRA  MNRSRHQLNL  DITRKEVREH  IMNQIFKVLD  ACKADYVKWD480
MNRSVDNVFS  AALPKERQGE  VYHRYVLAVY  EMMESLVQRY  PDLLFESCSG  GGGRFEAGML540
YYSPQIWCSD  NTDAIDRLKI  QYGTSFGYPI  STMGAHVSVC  PNHQSGRTTP  FETRGIVASA600
GTFGYELDLM  KMSEEDKKIA  KEQILKYKEM  EHLVQSGDYY  RLVNPFENNN  HVLWQFVSKD660
KKETVVCGVR  LHSEANPYIY  LFYPQGLDAD  MKYEDTATGK  VYTGAALMKA  GLPLPLTTGD720
YQPIKFTFKA  VEK733

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap367310914618321925629332936640343947651354958662365969612713GH36
Family Start End Evalue family coverage
GH36 12 713 1.4e-270 0.997093023255814

CDD Domains      download full data without filtering help

Created with Snap3673109146183219256293329366403439476513549586623659696291637Melibiase10729GalA330629GH3632287Glyco_hydro_36N654722Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam02065 Melibiase 0.0 291 637 1 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
COG3345 GalA 0.0 10 729 1 685
Alpha-galactosidase [Carbohydrate transport and metabolism].
cd14791 GH36 5.12e-142 330 629 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 2.61e-111 32 287 3 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 8.88e-25 654 722 4 72
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap367310914618321925629332936640343947651354958662365969611725AWY99332.1|GH364731BCK01162.1|GH364730BCN32673.1|GH364731QRP38527.1|GH364731ASN96678.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
AWY99332.1 1.89e-292 11 725 8 720
BCK01162.1 1.34e-290 4 731 3 727
BCN32673.1 6.27e-287 4 730 3 730
QRP38527.1 1.10e-285 4 731 3 733
ASN96678.1 1.10e-285 4 731 3 733

PDB Hits      download full data without filtering help

Created with Snap367310914618321925629332936640343947651354958662365969647282YFN_A47334FNQ_A47334FNR_A47334FNU_A47334FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
2YFN_A 7.30e-277 4 728 3 717
galactosidasedomain of alpha-galactosidase-sucrose kinase, AgaSK [[Ruminococcus] gnavus E1],2YFO_A GALACTOSIDASE DOMAIN OF ALPHA-GALACTOSIDASE-SUCROSE KINASE, AGASK, in complex with galactose [[Ruminococcus] gnavus E1]
4FNQ_A 3.82e-246 4 733 3 729
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 3.54e-244 4 733 3 729
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 3.27e-242 4 733 3 729
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNP_A 3.27e-242 4 733 3 729
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap36731091461832192562933293664034394765135495866236596964733sp|G4T4R7|AGASK_RUMGN4733sp|Q9ALJ4|AGAA_GEOSE4731sp|G1UB44|MELA_LACAC1731sp|P43467|AGAL1_PEDPE10728sp|P27756|AGAL_STRMU
Hit ID E-Value Query Start Query End Hit Start Hit End Description
G4T4R7 4.33e-273 4 733 3 722
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q9ALJ4 1.94e-243 4 733 3 729
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 1.60e-240 4 731 6 731
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.05e-233 1 731 1 730
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
P27756 1.36e-172 10 728 7 717
Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000062 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002312_02519.