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CAZyme Information: MGYG000002321_01715
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Ruminococcus_D bicirculans | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Ruminococcus_D; Ruminococcus_D bicirculans | |||||||||||
| CAZyme ID | MGYG000002321_01715 | |||||||||||
| CAZy Family | CBM35 | |||||||||||
| CAZyme Description | Mannan endo-1,4-beta-mannosidase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1812219; End: 1813871 Strand: - | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH26 | 207 | 531 | 5.9e-101 | 0.9966996699669967 |
| CBM35 | 74 | 189 | 3.1e-18 | 0.9831932773109243 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam02156 | Glyco_hydro_26 | 1.15e-59 | 208 | 531 | 2 | 311 | Glycosyl hydrolase family 26. |
| cd04086 | CBM35_mannanase-like | 2.64e-17 | 74 | 190 | 4 | 119 | Carbohydrate Binding Module 35 (CBM35); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains. This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes, including periplasmic component of ABC-type sugar transport system involved in carbohydrate transport and metabolism, and several glycoside hydrolase (GH) domains, including GH26. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. Examples of proteins having CMB35s belonging to this family are mannanase A from Clostridium thermocellum (GH26), Man26B from Paenibacillus sp. BME-14 (GH26), and the multifunctional Cel44C-Man26A from Paenibacillus polymyxa GS01 (which has two GH domains, GH44 and GH26). GH26 mainly includes mannan endo-1,4-beta-mannosidase which hydrolyzes 1,4-beta-D-linkages in mannans, galacto-mannans, glucomannans, and galactoglucomannans, but displays little activity towards other plant cell wall polysaccharides. A few proteins belonging to this family have additional CBM3 domains; these CBM3s are not found in the CBM6-CBM35-CBM36_like superfamily. |
| pfam16990 | CBM_35 | 3.17e-15 | 74 | 191 | 3 | 119 | Carbohydrate binding module (family 35). This is a mannan-specific carbohydrate binding domain, previously known as the X4 module. Unlike other carbohydrate binding modules, binding to substrate causes a conformational change. |
| COG4124 | ManB2 | 1.61e-13 | 330 | 443 | 151 | 256 | Beta-mannanase [Carbohydrate transport and metabolism]. |
| cd04083 | CBM35_Lmo2446-like | 3.92e-10 | 74 | 189 | 4 | 125 | Carbohydrate Binding Module 35 (CBM35) domains similar to Lmo2446. This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes. Some CBM35 domains belonging to this family are appended to glycoside hydrolase (GH) family domains, including glycoside hydrolase family 31 (GH31), for example the CBM35 domain of Lmo2446, an uncharacterized protein from Listeria monocytogenes EGD-e. These CBM35s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. GH31 has a wide range of hydrolytic activities such as alpha-glucosidase, alpha-xylosidase, 6-alpha-glucosyltransferase, or alpha-1,4-glucan lyase, cleaving a terminal carbohydrate moiety from a substrate that may be a starch or a glycoprotein. Most characterized GH31 enzymes are alpha-glucosidases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CCO05353.1 | 0.0 | 1 | 550 | 1 | 550 |
| ADU20856.1 | 6.93e-261 | 47 | 547 | 54 | 556 |
| BCN30368.1 | 2.23e-123 | 56 | 541 | 60 | 536 |
| ADU21390.1 | 1.02e-122 | 74 | 542 | 32 | 493 |
| QIZ03395.1 | 1.85e-122 | 86 | 538 | 67 | 511 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3ZM8_A | 1.47e-83 | 66 | 532 | 8 | 447 | ChainA, Gh26 Endo-beta-1,4-mannanase [Podospora anserina S mat+] |
| 6HPF_A | 3.46e-73 | 208 | 532 | 8 | 310 | Structureof Inactive E165Q mutant of fungal non-CBM carrying GH26 endo-b-mannanase from Yunnania penicillata in complex with alpha-62-61-di-galactosyl-mannotriose [Yunnania penicillata] |
| 3WDQ_A | 2.68e-60 | 196 | 533 | 24 | 353 | Crystalstructure of beta-mannanase from a symbiotic protist of the termite Reticulitermes speratus [Symbiotic protist of Reticulitermes speratus],3WDR_A Crystal structure of beta-mannanase from a symbiotic protist of the termite Reticulitermes speratus complexed with gluco-manno-oligosaccharide [Symbiotic protist of Reticulitermes speratus] |
| 6HF2_A | 3.30e-55 | 191 | 536 | 29 | 360 | Thestructure of BoMan26B, a GH26 beta-mannanase from Bacteroides ovatus [Bacteroides ovatus ATCC 8483],6HF4_A The structure of BoMan26B, a GH26 beta-mannanase from Bacteroides ovatus, complexed with G1M4 [Bacteroides ovatus ATCC 8483] |
| 6D2X_A | 4.62e-48 | 206 | 532 | 4 | 334 | Crystalstructure of the GH26 domain from PbGH26-GH5A endo-beta-mannanase/endo-beta-glucanase from Prevotella bryantii [Prevotella bryantii B14] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| G2Q4H7 | 8.28e-85 | 74 | 532 | 45 | 476 | Mannan endo-1,4-beta-mannosidase OS=Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) OX=573729 GN=Man26A PE=1 SV=1 |
| P49425 | 3.06e-73 | 74 | 538 | 20 | 463 | Mannan endo-1,4-beta-mannosidase OS=Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10) OX=518766 GN=manA PE=1 SV=3 |
| P55297 | 7.55e-65 | 74 | 534 | 25 | 463 | Mannan endo-1,4-beta-mannosidase B OS=Piromyces sp. OX=45796 GN=MANB PE=2 SV=1 |
| A2R6F5 | 1.74e-64 | 194 | 530 | 16 | 331 | Mannan endo-1,4-beta-mannosidase man26A OS=Aspergillus niger (strain CBS 513.88 / FGSC A1513) OX=425011 GN=man26A PE=1 SV=1 |
| P55296 | 8.02e-64 | 74 | 534 | 25 | 462 | Mannan endo-1,4-beta-mannosidase A OS=Piromyces sp. OX=45796 GN=MANA PE=2 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000000 | 0.000004 | 1.000045 | 0.000000 | 0.000000 | 0.000000 |