CAZyme Information: MGYG000002326_03789

Basic Information

• Species: Alkalihalobacillus alcalophilus
• Lineage: Bacteria; Firmicutes; Bacilli; Bacillales_H; Bacillaceae_D; Alkalihalobacillus; Alkalihalobacillus alcalophilus
• CAZyme ID: MGYG000002326_03789
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1A/1B

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
875		97360.8	4.0481

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002326	4217920	Isolate	not provided	not provided

• Gene Location: Start: 3534; End: 6161 Strand: +

Full Sequence      

MSDHNKSNPPSAKSRVEKRKQAQKNQTKPKKKGIWKKIFITLVALFMLAVVAGGITVFAI
VQSSPELDSDKLILTQGSEIFDQNDQSVSMLNSSENRINIDYADIPDVLEDAFLSVEDVR
FREHFGMDMRRFFGAVLANITDGFGAEGASTITQQLVKNLFLTDEKRLSRKIQEAYLAIQ
LEQKYSKDQILTMYLNQIYLGGGVYGVELASQRYFGKSIADLNLEDAALLAAIPRRPSFY
DPIQNPENAESRRNVVLSLMEQHGKISSEEATAAKEVPIADQMNPTEFESYPYEAYYNFI
MSELENIDGITLTDVYNSGLKVYTTLDVGAQEHLEEVLASDDYIAHFPDNELFQAGVSVL
DTQTGAIKALGSGREDTGYQLGLNYATDIKRQPGSTIKPILDYGPAIEHLQWSTGKILND
KPTTYNDRDQTPVNNFDRRHLGNMTMREALGRSRNTTAIQALQEVGVDKAAEFARGLGID
TGNEDEPMHESYGLGGFTNGISSLDLAAAYAAFGNGGTYTKPYAIRKVVFPDGRELNLEP
ETHKAMEDYTAYMITDMLKSVVTASYGTGGSANVSGVPLAGKTGTTNFTPEQIEEHRYPD
GAVPDSWFAGYSSRYSIAVWTGFEKRDDTTYLANADERRVPQHIFREMMSYLSADIDTPD
FQMPDSVVRVGVERSTGLLPSPFTPSSEIIQELFVRGTEQTQVSEKFVDIEAPSGVRAVY
QEDQDQIIVTWNYPQDLLDDVNFEVRLSINGGSNETVQQSNDMQYIYSNPEPGSTYEFSI
TAEYEGETSDPARASVEIPDAIEEEEPEPEEENVEEDTEDNNDEDQTEDGNGDDSGEDTG
SDENEDDNGGEEENNNEGTRPEDEEQEEDIETEEE

Enzyme Prediction     

No EC number prediction in MGYG000002326_03789.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	93	261	1.5e-66	0.9491525423728814

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	0.0	96	655	1	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	0.0	42	704	20	650	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	8.42e-133	42	713	10	774	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	3.32e-96	88	678	136	706	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	1.45e-89	47	705	4	618	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ADC51186.1	0.0	19	806	11	798
ARK30352.1	0.0	42	798	39	803
CBF97170.1	0.0	19	812	11	802
CBF93650.1	0.0	19	812	11	802
BAB05421.1	0.0	19	812	11	802

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	5.11e-121	78	667	8	602	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	3.58e-114	78	667	17	611	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
2C5W_B	4.77e-79	293	671	3	379	PENICILLIN-BINDINGPROTEIN 1A (PBP-1A) ACYL-ENZYME COMPLEX (CEFOTAXIME) FROM STREPTOCOCCUS PNEUMONIAE [Streptococcus pneumoniae R6]
2C6W_B	6.45e-79	293	671	2	378	Penicillin-BindingProtein 1a (Pbp-1a) From Streptococcus Pneumoniae [Streptococcus pneumoniae]
2ZC5_B	1.07e-78	293	671	5	381	ChainB, Penicillin-binding protein 1A [unidentified],2ZC5_D Chain D, Penicillin-binding protein 1A [unidentified],2ZC6_B Chain B, Penicillin-binding protein 1A [unidentified],2ZC6_D Chain D, Penicillin-binding protein 1A [unidentified]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39793	5.75e-194	24	806	23	797	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
Q04707	1.82e-143	36	685	11	664	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	7.13e-143	36	685	11	664	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
Q00573	4.88e-139	34	663	9	637	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
P38050	6.58e-105	36	650	7	595	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999929	0.000085	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
38	60