You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000002342_01710
You are here: Home > Sequence: MGYG000002342_01710
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Acinetobacter variabilis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter variabilis | |||||||||||
| CAZyme ID | MGYG000002342_01710 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 17865; End: 19811 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG0365 | Acs | 0.0 | 66 | 622 | 1 | 525 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]. |
| cd17634 | ACS-like | 0.0 | 22 | 609 | 1 | 587 | acetate-CoA ligase. This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain. |
| PRK00174 | PRK00174 | 0.0 | 4 | 644 | 1 | 634 | acetyl-CoA synthetase; Provisional |
| cd05966 | ACS | 0.0 | 21 | 632 | 2 | 608 | Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme). Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation. |
| PLN02654 | PLN02654 | 0.0 | 4 | 641 | 14 | 662 | acetate-CoA ligase |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 8.10e-245 | 21 | 641 | 581 | 1211 |
| CAE6201338.1 | 1.11e-244 | 21 | 641 | 592 | 1222 |
| QND46664.1 | 1.10e-20 | 106 | 613 | 2099 | 2576 |
| AFZ04852.1 | 2.71e-20 | 59 | 613 | 565 | 1074 |
| AFY93865.1 | 1.26e-16 | 72 | 613 | 329 | 842 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2P2F_A | 1.47e-317 | 5 | 644 | 7 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 5JRH_A | 1.99e-317 | 5 | 644 | 7 | 646 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
| 2P2M_A | 4.23e-317 | 5 | 644 | 7 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2B_A | 5.98e-317 | 5 | 644 | 7 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2B_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2Q_A | 8.51e-317 | 5 | 644 | 7 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q4UP35 | 0.0 | 1 | 642 | 1 | 643 | Acetyl-coenzyme A synthetase OS=Xanthomonas campestris pv. campestris (strain 8004) OX=314565 GN=acsA PE=3 SV=1 |
| Q7MGU3 | 0.0 | 4 | 642 | 6 | 645 | Acetyl-coenzyme A synthetase OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=acsA PE=3 SV=2 |
| Q6LLZ1 | 0.0 | 4 | 644 | 6 | 646 | Acetyl-coenzyme A synthetase OS=Photobacterium profundum (strain SS9) OX=298386 GN=acsA PE=3 SV=1 |
| Q66FM8 | 0.0 | 5 | 647 | 7 | 649 | Acetyl-coenzyme A synthetase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) OX=273123 GN=acs PE=3 SV=1 |
| Q88EH6 | 0.0 | 4 | 640 | 6 | 642 | Acetyl-coenzyme A synthetase 1 OS=Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) OX=160488 GN=acsA1 PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000040 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |