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CAZyme Information: MGYG000002351_00834

You are here: Home > Sequence: MGYG000002351_00834

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Klebsiella_A michiganensis
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella_A; Klebsiella_A michiganensis
CAZyme ID MGYG000002351_00834
CAZy Family GH18
CAZyme Description Chitinase A
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
699 MGYG000002351_1|CGC13 76198 4.1858
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002351 6684898 Isolate United States North America
Gene Location Start: 875080;  End: 877179  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 54 469 4e-61 0.9391891891891891

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3325 ChiA 6.04e-132 18 482 3 439
Chitinase, GH18 family [Carbohydrate transport and metabolism].
cd06548 GH18_chitinase 2.92e-94 55 467 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 2.32e-63 54 467 1 334
Glyco_18 domain.
pfam00704 Glyco_hydro_18 2.75e-58 54 467 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 8.57e-35 58 467 4 341
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QQO69948.1 0.0 1 699 1 699
QTH50643.1 0.0 1 699 1 699
AUV94325.1 0.0 1 699 1 699
QFI07806.1 0.0 1 699 1 699
AOV10379.1 0.0 1 699 1 699

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6OGD_C 6.09e-119 32 497 130 619
Cryo-EMstructure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_F Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_I Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_L Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_O Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga]
4DWS_A 2.93e-118 32 500 43 535
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_D 1.15e-117 32 497 43 532
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_B 8.99e-117 32 497 43 532
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_C 8.99e-117 32 500 43 535
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
B6A879 3.34e-118 32 497 130 619
Chitinase 2 OS=Yersinia entomophaga OX=935293 GN=chi2 PE=1 SV=1
B6A876 1.05e-105 22 496 38 520
Chitinase 1 OS=Yersinia entomophaga OX=935293 GN=chi1 PE=1 SV=1
P32823 4.72e-45 44 683 148 809
Chitinase A OS=Pseudoalteromonas piscicida OX=43662 GN=chiA PE=1 SV=1
P20533 2.16e-41 54 479 45 451
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
P07254 3.76e-37 54 480 158 557
Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000027 0.000010 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002351_00834.