logo
sublogo
You are browsing environment: HUMAN GUT
help

CAZyme Information: MGYG000002354_01945

You are here: Home > Sequence: MGYG000002354_01945

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Moellerella wisconsensis
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Moellerella; Moellerella wisconsensis
CAZyme ID MGYG000002354_01945
CAZy Family GH18
CAZyme Description Chitinase A
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
507 55887.65 4.7387
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002354 3303166 Isolate not provided not provided
Gene Location Start: 349234;  End: 350757  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 52 469 2.4e-57 0.9391891891891891

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 3.45e-92 53 467 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
COG3325 ChiA 9.93e-90 21 481 7 437
Chitinase, GH18 family [Carbohydrate transport and metabolism].
smart00636 Glyco_18 5.44e-66 52 467 1 334
Glyco_18 domain.
pfam00704 Glyco_hydro_18 1.10e-60 52 467 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 3.11e-42 53 467 1 341
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CDM88312.1 1.38e-208 3 499 2 495
CBJ80778.1 1.29e-206 3 499 2 495
AOM41160.1 1.84e-206 3 499 2 495
AKH65279.1 1.85e-205 3 498 2 502
QMV52212.1 2.78e-203 3 498 2 493

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6OGD_C 2.07e-116 3 500 100 621
Cryo-EMstructure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_F Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_I Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_L Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga],6OGD_O Cryo-EM structure of YenTcA in its prepore state [Yersinia entomophaga]
4DWS_D 3.80e-116 3 500 13 534
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_C 8.47e-115 3 500 13 534
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_A 1.69e-114 3 500 13 534
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]
4DWS_B 1.88e-113 3 500 13 534
CrystalStructure of a chitinase from the Yersinia entomophaga toxin complex [Yersinia entomophaga]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
B6A879 1.13e-115 3 500 100 621
Chitinase 2 OS=Yersinia entomophaga OX=935293 GN=chi2 PE=1 SV=1
B6A876 2.58e-112 11 502 28 525
Chitinase 1 OS=Yersinia entomophaga OX=935293 GN=chi1 PE=1 SV=1
P07254 1.30e-36 47 487 153 563
Chitinase A OS=Serratia marcescens OX=615 GN=chiA PE=1 SV=3
P20533 9.20e-36 52 480 45 451
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
O10363 6.62e-33 46 478 139 542
Probable endochitinase OS=Orgyia pseudotsugata multicapsid polyhedrosis virus OX=262177 GN=ORF124 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000035 0.000001 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002354_01945.