Species | Mycobacterium tuberculosis | |||||||||||
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Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis | |||||||||||
CAZyme ID | MGYG000002359_02498 | |||||||||||
CAZy Family | GT2 | |||||||||||
CAZyme Description | Dimodular nonribosomal peptide synthase | |||||||||||
CAZyme Property |
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Genome Property |
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Gene Location | Start: 27297; End: 32492 Strand: - |
Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
---|---|---|---|---|---|---|---|
PRK10252 | entF | 0.0 | 43 | 1076 | 10 | 1069 | enterobactin non-ribosomal peptide synthetase EntF. |
PRK05691 | PRK05691 | 0.0 | 44 | 1540 | 679 | 2190 | peptide synthase; Validated |
PRK12316 | PRK12316 | 0.0 | 27 | 1500 | 2586 | 4064 | peptide synthase; Provisional |
PRK12316 | PRK12316 | 0.0 | 41 | 1307 | 50 | 1320 | peptide synthase; Provisional |
cd05930 | A_NRPS | 0.0 | 502 | 972 | 1 | 444 | The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
---|---|---|---|---|---|
QND46664.1 | 7.20e-186 | 43 | 1525 | 563 | 2063 |
ACX49739.1 | 6.64e-180 | 43 | 1575 | 12 | 1578 |
BAY30132.1 | 2.40e-144 | 47 | 1053 | 2253 | 3291 |
BAZ00088.1 | 5.75e-144 | 43 | 1053 | 2247 | 3289 |
BAZ75991.1 | 5.75e-144 | 43 | 1053 | 2247 | 3289 |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
5U89_A | 2.43e-222 | 486 | 1521 | 22 | 1071 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
6P1J_A | 1.65e-146 | 43 | 972 | 8 | 964 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae] |
6OYF_A | 4.34e-126 | 43 | 878 | 5 | 873 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module [Eleftheria terrae],6OZV_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with AMP [Eleftheria terrae],6P4U_A The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo1 serine module in complex with Mg and AMP [Eleftheria terrae] |
6MFW_A | 9.72e-126 | 476 | 1514 | 195 | 1203 | Crystalstructure of a 4-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis] |
6MFX_A | 4.62e-125 | 476 | 1514 | 195 | 1203 | Crystalstructure of a 4-domain construct of a mutant of LgrA in the substrate donation state [Brevibacillus parabrevis] |
Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
---|---|---|---|---|---|---|
P45745 | 4.04e-241 | 37 | 1515 | 2 | 1495 | Dimodular nonribosomal peptide synthase OS=Bacillus subtilis (strain 168) OX=224308 GN=dhbF PE=1 SV=4 |
O30409 | 1.84e-221 | 31 | 1521 | 1051 | 2523 | Tyrocidine synthase 3 OS=Brevibacillus parabrevis OX=54914 GN=tycC PE=1 SV=1 |
Q70LM4 | 1.17e-203 | 47 | 1521 | 14 | 1503 | Linear gramicidin synthase subunit D OS=Brevibacillus parabrevis OX=54914 GN=lgrD PE=1 SV=1 |
O68007 | 2.91e-198 | 43 | 1525 | 78 | 1541 | Bacitracin synthase 2 OS=Bacillus licheniformis OX=1402 GN=bacB PE=3 SV=1 |
P94459 | 1.01e-195 | 22 | 1527 | 1038 | 2525 | Plipastatin synthase subunit D OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsD PE=1 SV=2 |
Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
---|---|---|---|---|---|
1.000056 | 0.000005 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
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