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CAZyme Information: MGYG000002365_01709
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bifidobacterium globosum | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Bifidobacteriaceae; Bifidobacterium; Bifidobacterium globosum | |||||||||||
| CAZyme ID | MGYG000002365_01709 | |||||||||||
| CAZy Family | GH36 | |||||||||||
| CAZyme Description | Alpha-galactosidase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1982487; End: 1984724 Strand: - | |||||||||||
Full Sequence Download help
| MAIMDFHGTS SRGEEVRIVY FEQRAARSAF ALAIVGDELP RIVHWGRPLA DPRTLVAAAD | 60 |
| ALRPQRVSGT LDETAWPSIL PTQAEAWIGS PRFVVRAGGM ELFCRFAVTD VRIDDDGVTV | 120 |
| DARDAEQGVR ILWRCELRES GLVRQRMTVV NMRSGELEIG TVELAFPVPA DMTEILTTTG | 180 |
| HHLRERSSQR QPFTIGRFQK ASLVGRPDFD SSLLLNVGRT GFGFTHGEVY SVHVAWSGNS | 240 |
| LMAAERLPYT SGLIGGAEAL SGGEVTLCVQ GGAGGDGACY TTPWLYGAYG EGLNEVAARF | 300 |
| HTELRTTHTQ WRAELGVPEK PRPVILNTWE AVYFQHDFGT LKALADKAAA SGVERFVVDD | 360 |
| GWFGGRRDDT AGLGDWWVSQ DVWPDGDHSL KALADYVHAK GMEFGLWFEP EMVNPDSAMY | 420 |
| REHPDWVLRP TANRLPMQGR NQQVVDLTNP QAYEYVYGCM DALVTELGID YIKWDHNKYV | 480 |
| TEAVSPRTGR PAVHGQTLAV YRIFHDLKTA HPGLEIESCS SGGGRVDLAI LSLADRIWAS | 540 |
| DCVDPVERAD IQRYTSLLVP PEMIGEHVGA SPAHSTHRAT SQQMRMAMAF FGHLGIEWNL | 600 |
| LKEPQSALDE LGVWVDAYKR HRADFAHGTV IHGDEADPAV RVDGVVSASG ERAVYRFTQL | 660 |
| TTSQTYPAAP VRLLGLDPDA DYLIQPLACN IGSGEPFTQI GNGQSELGWW NSQGIVMNGG | 720 |
| ALAAFGLRPP CIHPANAVLF SATRV | 745 |
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH36 | 26 | 687 | 6.6e-210 | 0.9665697674418605 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam02065 | Melibiase | 6.40e-159 | 280 | 628 | 2 | 347 | Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27. |
| cd14791 | GH36 | 9.08e-112 | 321 | 620 | 1 | 299 | glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
| COG3345 | GalA | 1.83e-108 | 42 | 685 | 23 | 649 | Alpha-galactosidase [Carbohydrate transport and metabolism]. |
| pfam16875 | Glyco_hydro_36N | 9.72e-38 | 39 | 263 | 2 | 252 | Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold. |
| cd14792 | GH27 | 1.06e-09 | 352 | 406 | 36 | 84 | glycosyl hydrolase family 27 (GH27). GH27 enzymes occur in eukaryotes, prokaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-N-acetylgalactosaminidase, and 3-alpha-isomalto-dextranase. All GH27 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH27 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AIZ16935.1 | 0.0 | 1 | 745 | 1 | 745 |
| ASW24133.1 | 0.0 | 1 | 745 | 1 | 745 |
| ATO39429.1 | 0.0 | 1 | 745 | 1 | 745 |
| ABB76662.1 | 0.0 | 1 | 745 | 1 | 741 |
| ATU19939.1 | 0.0 | 3 | 745 | 4 | 746 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4FNQ_A | 2.06e-74 | 21 | 687 | 12 | 695 | Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus] |
| 3MI6_A | 3.82e-74 | 174 | 684 | 192 | 695 | ChainA, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_B Chain B, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_C Chain C, Alpha-galactosidase [Levilactobacillus brevis ATCC 367],3MI6_D Chain D, Alpha-galactosidase [Levilactobacillus brevis ATCC 367] |
| 4FNR_A | 7.10e-72 | 184 | 687 | 201 | 695 | Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus] |
| 2XN0_A | 1.98e-71 | 174 | 682 | 195 | 693 | Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN0_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM, PtCl4 derivative [Lactobacillus acidophilus NCFM],2XN1_A Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_B Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_C Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM],2XN1_D Structure of alpha-galactosidase from Lactobacillus acidophilus NCFM with TRIS [Lactobacillus acidophilus NCFM] |
| 2XN2_A | 3.78e-71 | 174 | 682 | 195 | 693 | Structureof alpha-galactosidase from Lactobacillus acidophilus NCFM with galactose [Lactobacillus acidophilus NCFM] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P16551 | 2.42e-112 | 68 | 744 | 49 | 706 | Alpha-galactosidase OS=Escherichia coli OX=562 GN=rafA PE=1 SV=1 |
| Q9ALJ4 | 3.89e-71 | 184 | 687 | 201 | 695 | Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1 |
| G1UB44 | 1.08e-70 | 174 | 682 | 195 | 693 | Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1 |
| P27756 | 2.31e-70 | 166 | 684 | 177 | 684 | Alpha-galactosidase OS=Streptococcus mutans serotype c (strain ATCC 700610 / UA159) OX=210007 GN=aga PE=3 SV=3 |
| G4T4R7 | 7.12e-69 | 137 | 683 | 153 | 683 | Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000062 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |