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CAZyme Information: MGYG000002369_00588
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Clostridioides difficile | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes_A; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides; Clostridioides difficile | |||||||||||
| CAZyme ID | MGYG000002369_00588 | |||||||||||
| CAZy Family | GT44 | |||||||||||
| CAZyme Description | Toxin B | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 609917; End: 617017 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam12920 | TcdA_TcdB_pore | 0.0 | 862 | 1527 | 1 | 626 | TcdA/TcdB pore forming domain. This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region. |
| pfam12919 | TcdA_TcdB | 1.53e-161 | 96 | 468 | 1 | 382 | TcdA/TcdB catalytic glycosyltransferase domain. This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein. |
| cd20502 | C80_toxinA_B-like | 3.56e-88 | 577 | 791 | 1 | 209 | Peptidase C80 cysteine binding domain of Clostridium difficile toxins A and B, and related proteins. This peptidase C80 family includes the major virulence factors of Clostridium difficile multidomain toxins TcdA and TcdB. These large homologous toxins contain several distinct domains including a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding of intracellular inositol hexakisphosphate. C. difficile is a major cause of intestinal tissue damage and inflammation, and TcdA is generally more inflammatory whereas TcdB is more cytotoxic; studies show that the CPD is an internal regulator of the proinflammatory activity. Site-directed mutagenesis has identified functional residues Asp/His/Cys in Clostridium toxin B. |
| pfam11713 | Peptidase_C80 | 1.12e-52 | 575 | 754 | 1 | 152 | Peptidase C80 family. This family belongs to cysteine peptidase family C80. |
| cd21058 | toxin_MLD_like | 3.63e-31 | 5 | 84 | 1 | 78 | membrane localization domain (MLD) of Vibrio MARTX, Pasteurella PMT, clostridial glycosylating cytotoxins, toxin effectors BteA (Bordetella T3SS effector A) and related proteins. This family includes membrane localization domains (MLDs) for toxin effectors such as the Rho-inactivation domain of Vibrio MARTX, Pasteurella mitogenic toxin (PMT), where it has been termed PMT C1 domain, and clostridial glycosylating cytotoxins including Clostridium difficile toxins A (TcdA) and B (TcdB), Clostridium novyi alpha-toxin (TcnA), and Clostridium sordellii lethal toxin (TcsL). It also includes the MLD located in the N-terminal minimal membrane-binding fragment of BteA, a type III secretion system (T3SS) effector protein from Bordetella pertussis, the causative agent of whooping cough. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AYD23938.1 | 0.0 | 1 | 2366 | 1 | 2366 |
| AGG91604.1 | 0.0 | 1 | 2366 | 1 | 2366 |
| AYD11780.1 | 0.0 | 1 | 2366 | 1 | 2366 |
| CBE02479.1 | 0.0 | 1 | 2366 | 1 | 2366 |
| AVB59648.1 | 0.0 | 1 | 2366 | 1 | 2366 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7N8X_A | 0.0 | 374 | 1853 | 1 | 1480 | ChainA, Toxin B [Clostridioides difficile] |
| 7N97_A | 0.0 | 2 | 2366 | 1 | 2365 | ChainA, Toxin B [Clostridioides difficile],7N9Q_A Chain A, Toxin B [Clostridioides difficile],7N9S_A Chain A, Toxin B [Clostridioides difficile],7N9Y_A Chain A, Toxin B [Clostridioides difficile] |
| 7N95_A | 0.0 | 1 | 2366 | 1 | 2366 | ChainA, Toxin B [Clostridioides difficile],7N9R_A Chain A, Toxin B [Clostridioides difficile] |
| 7POG_A | 0.0 | 1 | 1949 | 1 | 1947 | ChainA, Toxin A [Clostridioides difficile] |
| 7ML7_A | 0.0 | 1 | 1949 | 40 | 1988 | ChainA, Toxin B [Clostridioides difficile] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P0DUB4 | 0.0 | 1 | 2366 | 1 | 2364 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| P16154 | 0.0 | 1 | 1949 | 1 | 1947 | Toxin A OS=Clostridioides difficile OX=1496 GN=tcdA PE=1 SV=2 |
| P18177 | 0.0 | 1 | 2366 | 1 | 2366 | Toxin B OS=Clostridioides difficile OX=1496 GN=tcdB PE=1 SV=3 |
| Q46342 | 0.0 | 1 | 2366 | 1 | 2364 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| Q9EXR0 | 0.0 | 1 | 2366 | 1 | 2367 | Toxin B OS=Clostridioides difficile OX=1496 GN=tcdB PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000041 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |