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CAZyme Information: MGYG000002376_02400

You are here: Home > Sequence: MGYG000002376_02400

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Lachnoclostridium_B sp000765215
Lineage Bacteria; Firmicutes_A; Clostridia; Lachnospirales; Lachnospiraceae; Lachnoclostridium_B; Lachnoclostridium_B sp000765215
CAZyme ID MGYG000002376_02400
CAZy Family GH36
CAZyme Description Alpha-galactosidase AgaA
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
747 MGYG000002376_32|CGC2 85634.44 5.7368
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002376 3267429 Isolate Denmark Europe
Gene Location Start: 154463;  End: 156706  Strand: -

Full Sequence      Download help

MNIIWREESR  TFHLYNDQVS  YIMKVLRCGQ  LGQLYFGKRV  HDRDDFSYLL  ENLPRPMASC60
TFEDSKAYSL  EHIKQEYPSY  GTGDYRSPAV  EILQENGSRI  SAFVYKSHRI  SDGKPSLEGL120
PATYTEDDSE  ARTLTVTMED  AVTGMTLELS  YTIFAQGGII  ARSARFVNRG  EQPLHLTTAM180
SLCLDLPDHD  YDWMQFSGAW  ARERYPRVRR  LEEGILSVGS  RRGHSSHEHN  PFIILKRPQA240
DEFQGEAIGF  SLVYSGNFLA  QAEVGSHDTT  RVLMGIHPDG  FDWKLEPKEA  FQTPEAVMVY300
TDRGLNDLSQ  TFHRLYQKRL  ARGYWRDRER  PILINNWEAT  YFDFTEGKIL  EIAGKARECG360
VEMFVLDDGW  FGKRCSDRAG  LGDWVANRDR  LPGGIAGLAQ  KIDDMGMKFG  LWFEPEMVNK420
DSDLYRAHPD  WILHVPGRPS  THGRYQYVLD  FSRKEVVDCI  YGMMEKILSE  AKISYIKWDM480
NRSITECYSP  ALPADRQGEV  FHRYILGVYD  LYDRLTRKFP  YVLFESCASG  GARFDPGMLY540
YAPQAWTSDD  TDAVERLKIQ  YGTSYCYPVS  SMGSHVSTSP  NHQTGRTAPL  HTRANVACFG600
TFGYELDLNT  LTAEEQEAVK  DQIRFMKEYR  HLLQFGTFYR  LQSPFEGNVT  AWMAVSKDKK660
EAIAGWYRTL  SGANLAYTRL  PLRGLDPEAR  YEIQVRKETE  QPFGSFYGDE  LMNIGLITTD720
GTAGEVTDRE  NAPRDFDSRL  FILKAEE747

Enzyme Prediction      help

EC 3.2.1.22

CAZyme Signature Domains help

Created with Snap377411214918622426129833637341044848552256059763467270912716GH36
Family Start End Evalue family coverage
GH36 12 716 2.2e-297 0.9941860465116279

CDD Domains      download full data without filtering help

Created with Snap377411214918622426129833637341044848552256059763467270912744GalA291636Melibiase329628GH3629286Glyco_hydro_36N649743Glyco_hydro_36C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3345 GalA 0.0 12 744 4 685
Alpha-galactosidase [Carbohydrate transport and metabolism].
pfam02065 Melibiase 0.0 291 636 2 347
Melibiase. Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K. This family includes enzymes from GH36A-B and GH36D-K and from GH27.
cd14791 GH36 3.58e-149 329 628 1 299
glycosyl hydrolase family 36 (GH36). GH36 enzymes occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.
pfam16875 Glyco_hydro_36N 2.89e-127 29 286 1 256
Glycosyl hydrolase family 36 N-terminal domain. This domain is found at the N-terminus of many family 36 glycoside hydrolases. It has a beta-supersandwich fold.
pfam16874 Glyco_hydro_36C 5.36e-25 649 743 1 78
Glycosyl hydrolase family 36 C-terminal domain. This domain is found at the C-terminus of many family 36 glycoside hydrolases. It has a beta-sandwich structure with a Greek key motif.

CAZyme Hits      help

Created with Snap37741121491862242612983363734104484855225605976346727091746QJU18218.1|GH361745QIB59452.1|GH361744BDA09616.1|GH361745CBL06499.1|GH361746SNU95754.1|GH36
Hit ID E-Value Query Start Query End Hit Start Hit End
QJU18218.1 0.0 1 746 1 740
QIB59452.1 0.0 1 745 1 740
BDA09616.1 0.0 1 744 1 739
CBL06499.1 0.0 1 745 1 740
SNU95754.1 0.0 1 746 1 741

PDB Hits      download full data without filtering help

Created with Snap377411214918622426129833637341044848552256059763467270917164FNQ_A17164FNR_A17164FNU_A17164FNT_A17164FNP_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
4FNQ_A 3.58e-283 1 716 1 708
Crystalstructure of GH36 alpha-galactosidase AgaB from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNR_A 3.34e-281 1 716 1 708
Crystalstructure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_B Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_C Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNR_D Crystal structure of GH36 alpha-galactosidase AgaA from Geobacillus stearothermophilus [Geobacillus stearothermophilus]
4FNU_A 3.12e-279 1 716 1 708
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus],4FNU_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D478A from Geobacillus stearothermophilus in complex with stachyose [Geobacillus stearothermophilus]
4FNT_A 4.42e-279 1 716 1 708
Crystalstructure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_B Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_C Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus],4FNT_D Crystal structure of GH36 alpha-galactosidase AgaA A355E D548N from Geobacillus stearothermophilus in complex with raffinose [Geobacillus stearothermophilus]
4FNP_A 6.27e-279 1 716 1 708
Crystalstructure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNP_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus [Geobacillus stearothermophilus],4FNS_A Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_B Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_C Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus],4FNS_D Crystal structure of GH36 alpha-galactosidase AgaA A355E from Geobacillus stearothermophilus in complex with 1-deoxygalactonojirimycin [Geobacillus stearothermophilus]

Swiss-Prot Hits      download full data without filtering help

Created with Snap37741121491862242612983363734104484855225605976346727091716sp|Q9ALJ4|AGAA_GEOSE7716sp|G1UB44|MELA_LACAC7716sp|P43467|AGAL1_PEDPE1716sp|G4T4R7|AGASK_RUMGN71716sp|Q0CEF5|AGALG_ASPTN
Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q9ALJ4 1.83e-280 1 716 1 708
Alpha-galactosidase AgaA OS=Geobacillus stearothermophilus OX=1422 GN=agaA PE=1 SV=1
G1UB44 2.36e-225 7 716 10 712
Alpha-galactosidase Mel36A OS=Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) OX=272621 GN=melA PE=1 SV=1
P43467 1.38e-216 7 716 8 711
Alpha-galactosidase 1 OS=Pediococcus pentosaceus OX=1255 GN=agaR PE=3 SV=1
G4T4R7 3.83e-200 1 716 1 701
Bifunctional alpha-galactosidase/sucrose kinase AgaSK OS=Ruminococcus gnavus OX=33038 GN=agaSK PE=1 SV=1
Q0CEF5 1.75e-184 71 716 67 707
Probable alpha-galactosidase G OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) OX=341663 GN=aglG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000065 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002376_02400.