CAZyme Information: MGYG000002378_00718

Basic Information

• Species: Akkermansia sp001580195
• Lineage: Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia sp001580195
• CAZyme ID: MGYG000002378_00718
• CAZy Family: GH0
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
716		79048.36	6.2713

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002378	3103583	Isolate	not provided	not provided

• Gene Location: Start: 294377; End: 296527 Strand: -

Full Sequence      

MDQDRILYRGEAFTLTGSRLSQDDSHWAEVEKDGRVRTMKNGRYSEWRIVPETEYGPRYH
SGFEVLNKAYCLALNEAGALINEEGTFRTGANWPTVWTRDIAYATHLGLGMWNVQACMKS
LQARVRKGEVEQDTGTGGSWPISSDRVVWSVAAWEVYCLTGDGDWLLRASRVLEKTCLKD
EKVLTATGGLMRGESSFLDWREQSYPAWMTSADIGDSSSLSTMILHAAARKMLARMFREL
GMEGKAREWDGKGEALSGVIEKFFRIPGSDLYGQYLYGRGYPVLSEKVDSLGNILCVLLG
HAHGAHAARMVAALPHCVYGIPCFHPQMPEDVAPYHNRATWPFLEGYYAQAAAATGNECG
LALALACMVRAALLCGTNKENLLLETGLDEGLLLSSDSQLWSIAGMLGGFYKGLFGLRVS
PDSLEFRPCIPDSFAGVHELSGLQYRGMTVDVRVSGQGRRIVRCRINGQDADPVLPAGGK
GRMGVELELASDGENAGQVNLSHVKRSLASPEWKAGRHGIAWAAVDGADYYRVFRNGIPV
SQTEYCYYIAAPAEGEVHYQVMAVALDGRESFLNEPNEYPSADSRLETRPCGLAGDEAWS
SRVTKSPDALFYNVNIDRPGVYRVDAFFANGTYDVSDGNTCAMRSLYLNGRRAGTLAFPH
TSRSGNWDYFIYSTAVEVVLKPGPCRVELAYDSFSVNMNHLVNDAVIKHLRFTRIS

Enzyme Prediction     

No EC number prediction in MGYG000002378_00718.

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd04083	CBM35_Lmo2446-like	1.86e-07	608	702	37	124	Carbohydrate Binding Module 35 (CBM35) domains similar to Lmo2446. This family includes carbohydrate binding module 35 (CBM35) domains that are appended to several carbohydrate binding enzymes. Some CBM35 domains belonging to this family are appended to glycoside hydrolase (GH) family domains, including glycoside hydrolase family 31 (GH31), for example the CBM35 domain of Lmo2446, an uncharacterized protein from Listeria monocytogenes EGD-e. These CBM35s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. GH31 has a wide range of hydrolytic activities such as alpha-glucosidase, alpha-xylosidase, 6-alpha-glucosyltransferase, or alpha-1,4-glucan lyase, cleaving a terminal carbohydrate moiety from a substrate that may be a starch or a glycoprotein. Most characterized GH31 enzymes are alpha-glucosidases.
COG3459	COG3459	6.46e-05	157	489	733	1052	Cellobiose phosphorylase [Carbohydrate transport and metabolism].
COG3408	GDB1	0.003	164	451	373	639	Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism].
cd04079	CBM6_agarase-like	0.003	608	683	43	109	Carbohydrate Binding Module 6 (CBM6); appended mainly to glycoside hydrolase (GH) family 16 alpha- and beta agarases. This family includes carbohydrate binding module 6 (CBM6) domains that are appended mainly to glycoside hydrolase (GH) family 16 agarases. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the activity of alpha- and beta-agarase catalytic modules which are involved in the hydrolysis of 1,4-beta-D-galactosidic linkages. These CBM6s bind specifically to the non-reducing end of agarose chains, recognizing only the first repeat of the disaccharide, and directing the appended catalytic modules to areas of the plant cell wall attacked by beta-agarases. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. This family includes three tandem CBM6s from the Saccharophagus degradans agarase Aga86E, and three tandem CBM6s from Vibrio sp. strain PO-303 AgaA; in both these proteins these are appended to a GH16 domain. Vibrio AgaA also contains a Big-2-like protein-protein interaction domain. This family also includes two tandem CBM6s from an endo-type beta-agarase from a deep-sea Microbulbifer-like isolate, which are appended to a GH16 domain, and two of three CBM6s of Alteromonas agarilytica AgaA alpha-agarase, which are appended to a GH96 domain.
cd02795	CBM6-CBM35-CBM36_like	0.008	594	678	21	98	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules. This alignment model also contains the C-terminal domains of bacterial insecticidal toxins, where they may be involved in determining insect specificity through carbohydrate binding functionality.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AMR26804.1	5.10e-136	46	716	227	907
QJX46424.1	1.64e-134	45	716	229	911
QIX61349.1	1.94e-132	57	715	242	911
AKQ46615.1	6.52e-132	45	716	226	906
QMU30083.1	3.46e-131	45	716	209	890

PDB Hits     

has no PDB hit.

Swiss-Prot Hits     

has no Swissprot hit.

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000066	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002378_00718.