CAZyme Information: MGYG000002378_02003

Basic Information

• Species: Akkermansia sp001580195
• Lineage: Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia sp001580195
• CAZyme ID: MGYG000002378_02003
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
887		97756.1	9.8019

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002378	3103583	Isolate	not provided	not provided

• Gene Location: Start: 110576; End: 113239 Strand: -

Full Sequence      

MGADDKSRKGNAGSWRERIPDAQPTSRAKSARRKRQPPRPSYPGLPGKEPRPAVIPGPTR
RTASPRDSSSPYGAPSPRPRKAPRPAPRVEYDEEEATPERSSRPSGKRRKPGFTIFGALW
FVLTMPFRFIGALTRNIRWFISWPLRILLSVSFVGIVVGAILVFLYGTISNRYDISEVKS
NIPERTVILDRKNRTIGTLHGENRRRVPLQEVPPIFIDALLLREDNRFYDHGGVDWIGVG
RAVAQVIKHKRATQGASTLTMQLAKITYNHQERNLHSKLTEVALAKRIEATYSKDEILET
YINRIFWGHTFLGIAAASRGYYDKEPRDLSLSECATLAGIIYGPNDFSPLKHPEEARKVR
DIVLGLLKDAGKITEVQYAAALAEPIVTHPPQSRSEENYAMDLVRRELDAILEEEDIRLG
GLVVHTTLDLDLQNATLDIINKHMTALESRKDFKKHLASLQARREKRGIVKNKLTTKAEY
EAALAAYKAIPAEQREKTQPPMPNYIQSAAVVMDNATGALLAVVGGRDAEESKLNRAIQS
RRQTGSLFKPFVYATFFQQGNSADTRISDDRIAYGEIRGAANWSPRNSDGTYCGMKPASF
GLILSRNTMSVRIGNRAGLGNVIQSAELAGFHGNVSKTPALFLGTWEASPLDVASAYSVF
ANGGVRPTPYIIDHITDSKGQPRFAITKSRRAVYSQRAANITSSILQQVCKPGGTAGRIT
ALGFKAPCGGKTGTTNNYTNAWFAGYTSNLTCSVWVGFDTPTKILEKGYGGTLALPIWTD
IMLASQKEGYPSNAIRTRAASEGQAVLICRESNQLAHSGCQYAKTAYYETTVGYQAPAKM
CEKHIPLAEPGTEEDIPYAEPLDSSDDNIPLAEPVDETDGIPYATPI

Enzyme Prediction     

No EC number prediction in MGYG000002378_02003.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	194	365	7.3e-58	0.9661016949152542

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	3.06e-166	131	782	5	593	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	5.12e-164	203	782	1	525	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	1.00e-153	148	861	8	788	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.62e-107	194	782	134	679	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
TIGR02073	PBP_1c	5.24e-90	183	821	9	573	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QWO92622.1	0.0	1	887	1	887
QWO92073.1	0.0	1	887	1	887
QWP69962.1	0.0	1	887	1	887
QWO85318.1	0.0	1	887	1	887
QWO95154.1	0.0	1	887	1	887

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3UDF_A	2.00e-84	193	796	28	725	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
4OON_A	3.53e-82	205	782	38	719	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
5U2G_A	1.25e-65	176	778	1	750	2.6Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20],5U2G_B 2.6 Angstrom Resolution Crystal Structure of Penicillin-Binding Protein 1A from Haemophilus influenzae [Haemophilus influenzae Rd KW20]
5FGZ_A	1.04e-64	196	778	148	686	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.44e-64	196	778	169	707	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
O87579	1.82e-88	158	796	21	715	Penicillin-binding protein 1A OS=Neisseria lactamica OX=486 GN=mrcA PE=3 SV=1
O87626	1.26e-86	154	780	21	699	Penicillin-binding protein 1A OS=Neisseria flavescens OX=484 GN=mrcA PE=3 SV=1
O05131	2.42e-86	154	782	21	702	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae OX=485 GN=mrcA PE=1 SV=3
Q5FAC7	2.42e-86	154	782	21	702	Penicillin-binding protein 1A OS=Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) OX=242231 GN=mrcA PE=3 SV=3
P0A0Z5	3.25e-85	154	782	21	702	Penicillin-binding protein 1A OS=Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) OX=122587 GN=mrcA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000046	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
112	134
147	169