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CAZyme Information: MGYG000002387_00036

You are here: Home > Sequence: MGYG000002387_00036

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Lactobacillus paragasseri
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus; Lactobacillus paragasseri
CAZyme ID MGYG000002387_00036
CAZy Family GH25
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
315 MGYG000002387_1|CGC2 34307.2 6.9688
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002387 2129154 Isolate South Korea Asia
Gene Location Start: 37234;  End: 38181  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002387_00036.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH25 12 196 2.7e-39 0.9717514124293786

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06415 GH25_Cpl1-like 8.19e-86 10 206 2 195
Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain, thus acting as an enzymatic antimicrobial agent (an enzybiotic) against streptococcal infections. Cpl-1 belongs to the CP family of lysozymes (CPL lysozymes) which includes the Cpl-7 lysin. Cpl-1 has a glycosyl hydrolase family 25 (GH25) catalytic domain with an irregular (beta/alpha)5-beta3 barrel and a C-terminal cell wall-anchoring module formed by six similar choline-binding repeats (ChBr's). The ChBr's facilitate the anchoring of Cpl-1 to the choline-containing teichoic acid of the pneumococcal cell wall. Other members of this domain family have an N-terminal CHAP (cysteine, histidine-dependent amidohydrolases/peptidases) domain similar to that of the firmicute CHAP lysins and associated with endopeptidase activity. The Cpl-7 lysin is also included here as is LysB of Lactococcus phage, and the Mur lysin of Lactobacillus phage.
pfam01183 Glyco_hydro_25 4.90e-27 12 194 1 174
Glycosyl hydrolases family 25.
smart00641 Glyco_25 1.73e-25 95 209 1 105
Glycosyl hydrolases family 25.
cd00599 GH25_muramidase 1.25e-22 10 215 1 185
Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family of muramidases contains a glycosyl hydrolase family 25 (GH25) catalytic domain and is found in bacteria, fungi, slime molds, round worms, protozoans and bacteriophages. The bacteriophage members are referred to as endolysins which are involved in lysing the host cell at the end of the replication cycle to allow release of mature phage particles. Endolysins are typically modular enzymes consisting of a catalytically active domain that hydrolyzes the peptidoglycan cell wall and a cell wall-binding domain that anchors the protein to the cell wall. Endolysins generally have narrow substrate specificities with either intra-species or intra-genus bacteriolytic activity.
cd06522 GH25_AtlA-like 7.85e-22 12 194 4 176
AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QTP20547.1 1.40e-237 1 315 1 315
ART97430.1 1.40e-237 1 315 1 315
QHC52901.1 1.40e-237 1 315 1 315
VEF35195.1 1.40e-237 1 315 1 315
QTP20251.1 3.70e-233 1 315 1 315

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
1H09_A 1.06e-30 12 247 8 217
ChainA, LYSOZYME [Streptococcus phage Cp1]
2IXU_A 1.08e-30 12 247 9 218
ChainA, LYSOZYME [Streptococcus phage Cp1]
2IXV_A 2.91e-30 12 247 9 218
ChainA, LYSOZYME [Streptococcus phage Cp1],2J8F_A Chain A, LYSOZYME [Streptococcus phage Cp1],2J8G_A Chain A, LYSOZYME [Streptococcus phage Cp1]
1OBA_A 2.09e-29 12 247 9 218
ChainA, Lysozyme [Streptococcus phage Cp1]
6AKV_A 9.66e-13 242 315 205 282
ChainA, LysB4 [Bacillus phage B4]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P33486 8.84e-34 8 185 3 181
Lysozyme OS=Lactococcus phage mv1 OX=33769 GN=lysA PE=1 SV=3
Q8HA43 8.23e-32 10 303 155 438
D-alanyl-L-alanine endopeptidase OS=Streptococcus phage B30 OX=209152 PE=1 SV=2
P15057 5.94e-30 12 247 9 218
Lysozyme OS=Streptococcus phage Cp-1 OX=10747 GN=CPL1 PE=1 SV=2
P19386 3.04e-27 12 247 9 218
Lysozyme OS=Streptococcus phage Cp-9 OX=10749 GN=CPL9 PE=3 SV=1
P19385 8.28e-26 12 216 9 197
Lysozyme OS=Streptococcus phage Cp-7 OX=10748 GN=CPL7 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.999935 0.000110 0.000006 0.000000 0.000000 0.000001

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002387_00036.