CAZyme Information: MGYG000002387_00473

Basic Information

• Species: Lactobacillus paragasseri
• Lineage: Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus; Lactobacillus paragasseri
• CAZyme ID: MGYG000002387_00473
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
942	MGYG000002387_1|CGC6	104100.25	9.7796

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002387	2129154	Isolate	South Korea	Asia

• Gene Location: Start: 454762; End: 457590 Strand: +

Full Sequence      

MKNLKEKIIEFLTAGPEVKTLQSESDESQWKFYSGIVYLTLRRVFHYLILIAVFGLFLLI
GFGGGYALGIVRQQPIPTISELNQQINHAQNSATLYYAGNKKIATVRSDTVTKKASESEL
TPLVKNAVTATEDENFYIHKGVLPKSLVRAVLSELTGVGVQTGGSTLTQQLVKMQFLTSQ
TTWRRKVTEMFYAHKIEKHFSKEDILRSYLNAAPYGKNNRGENIVGIKTAAQGIFGKSIS
ELNLPQAAFIAGLPQSPSIYTPYRLNGKIKKDLDLAMRRKDIVLFRMYRNGDISKKDYLA
AKKYDLRADFLAPEKASKQKKQSGYLYNLVMNKSTSLLAEKLIEQDGLKVSDVKQDTNRY
NQYLTSATELLHQKGYHIKTTIRQPLYQTMQRIVKQNKYGQDKTSRDFDSSTNKWVNTTE
HVENGSVVIDNATGKVLAFSGGVDFKNSQINHAFDTYRSPGSSIKPYLVYGPAIEHKLIS
SQTALADFPTRFGNYIPTDYNSTVENRFILAQEALSKSYNLPAVNLYSKLVNDKNINLRQ
DMKKLGLNLSKSEFENLGLALGGTDYGFSVADNASAFSNFYNNGKRADPYYIEEIQDPSG
RVIYKHKQNPQKVFSTGTSYIMQKMLHQVVTKGTASSLTGTLKFNYKNLIGKTGTSNDYR
DIWFNGSTPGITISSWMGYDNFYGHSYNLDSNSSETNLNLWANIANALYEEDPSIFKLND
APSRPSSVYKNRVLARTGTLPGTVSYDGDNIELSGKKTTALSLSPAPAATARFGIGGSTK
DYNLFYDYLEGKNNDYGKVLIYTGKTISKKKNINSLFAVADGSTSEDAKNYYGKNHEVYR
ESNNNSSSSTNRNVGANDQQARSTGQGGNNNGSSSSTSTRRNRSSSTGESSSSAESSNSE
SNNAANDVNSNISSNEGSAANTNTSSETTEGSTATNNGPTAP

Enzyme Prediction     

No EC number prediction in MGYG000002387_00473.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	102	288	7.8e-53	0.9774011299435028

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.03e-145	42	772	9	661	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	4.01e-132	119	710	9	530	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	8.88e-93	47	683	7	695	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
COG4953	PbpC	6.46e-78	119	726	65	565	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	1.95e-65	118	288	19	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QTP20030.1	0.0	1	942	1	942
ART97821.1	0.0	1	942	1	942
QHC52691.1	0.0	1	942	1	942
QTD66155.1	0.0	1	942	1	942
BBD48082.1	0.0	1	942	1	942

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
2JE5_A	5.07e-140	61	791	3	717	StructuralAnd Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6],2JE5_B Structural And Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6]
2FFF_B	3.28e-68	325	791	2	452	OpenForm of a Class A Transpeptidase Domain [Streptococcus pneumoniae]
2BG1_A	4.90e-68	325	791	41	491	Activesite restructuring regulates ligand recognition in classA Penicillin-binding proteins (PBPs) [Streptococcus pneumoniae R6],2XD5_A Structural insights into the catalytic mechanism and the role of Streptococcus pneumoniae PBP1b [Streptococcus pneumoniae R6],2XD5_B Structural insights into the catalytic mechanism and the role of Streptococcus pneumoniae PBP1b [Streptococcus pneumoniae R6]
2XD1_A	4.90e-68	325	791	41	491	ACTIVESITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS [Streptococcus pneumoniae R6],2XD1_B ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS [Streptococcus pneumoniae R6]
2UWX_A	2.43e-67	325	791	41	491	Activesite restructuring regulates ligand recognition in class A penicillin-binding proteins [Streptococcus pneumoniae R6]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P38050	6.99e-68	116	680	71	571	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P40750	1.73e-59	124	709	88	624	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2
A7GHV1	3.48e-58	124	746	88	676	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A7FY32	1.62e-57	124	746	88	676	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	1.62e-57	124	746	88	676	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999884	0.000125	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
44	66