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CAZyme Information: MGYG000002395_01248

You are here: Home > Sequence: MGYG000002395_01248

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Bifidobacterium adolescentis
Lineage Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Bifidobacteriaceae; Bifidobacterium; Bifidobacterium adolescentis
CAZyme ID MGYG000002395_01248
CAZy Family GT28
CAZyme Description UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
408 MGYG000002395_1|CGC17 43133.43 6.9355
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002395 2173720 Isolate China Asia
Gene Location Start: 1434448;  End: 1435674  Strand: -

Full Sequence      Download help

MPRGLPPHGG  LSSWIMSNQK  HIVLAGGGTA  GHVNPLLAVA  HVIRELEPEA  DIAVVGTAVG60
LERDLVPQAG  FELETIEKVP  FPRRPNKAAL  QFPAKWKAEK  AKVRDILTRH  QAQVVVGFGG120
YTSAPVYAAA  HSMGIPIAIH  EQNARAGMAN  KLGARWASMI  GAAYAQPGLK  PRRGVEVERV180
GLPLRPAIAR  LASDLEHDRT  ATRKAAAAQL  GVDPDRPLVV  ITGGSLGAVN  VNRAVAASAK240
DLLAHAQVIH  LTGKGKDDEV  RSLVSVSAGE  DVLGELGPDH  VSDGDYRVAP  YLERIDLAFA300
CADLIICRSG  AGTVSELTAL  GLPAIYVPLP  IGNGEQRFNA  QPVVDAEGGL  MVADGDFTPD360
WVRGHVPELL  ADPDKLSRYG  ANAWKYGIRD  AAEVMAKRVL  ALIDQPAD408

Enzyme Prediction      help

No EC number prediction in MGYG000002395_01248.

CAZyme Signature Domains help

Created with Snap20406181102122142163183204224244265285306326346367387219391GT28
Family Start End Evalue family coverage
GT28 219 391 3.8e-46 0.9872611464968153

CDD Domains      download full data without filtering help

Created with Snap2040618110212214216318320422424426528530632634636738720403murG21397GT28_MurG22403MurG20397murG218395Glyco_tran_28_C
Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK00726 murG 2.56e-131 20 403 2 355
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
cd03785 GT28_MurG 1.89e-113 21 397 1 349
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
COG0707 MurG 2.73e-94 22 403 3 355
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis].
TIGR01133 murG 1.54e-85 20 397 1 346
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase. RM 8449890 RT The final step of peptidoglycan subunit assembly in Escherichia coli occurs in the cytoplasm. RA Bupp K, van Heijenoort J. RL J Bacteriol 1993 Mar;175(6):1841-3 [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam04101 Glyco_tran_28_C 1.87e-34 218 395 1 166
Glycosyltransferase family 28 C-terminal domain. The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.

CAZyme Hits      help

Created with Snap2040618110212214216318320422424426528530632634636738716408AII76565.1|GT2816408AJE06217.1|GT2816408BAF39882.1|GT2816408AXR42028.1|GT2816408AZH71797.1|GT28
Hit ID E-Value Query Start Query End Hit Start Hit End
AII76565.1 2.67e-283 16 408 1 393
AJE06217.1 2.67e-283 16 408 1 393
BAF39882.1 2.67e-283 16 408 1 393
AXR42028.1 3.80e-283 16 408 1 393
AZH71797.1 7.66e-283 16 408 1 393

PDB Hits      download full data without filtering help

Created with Snap20406181102122142163183204224244265285306326346367387153991F0K_A173607D1I_A193763S2U_A
Hit ID E-Value Query Start Query End Hit Start Hit End Description
1F0K_A 2.27e-42 15 399 1 350
The1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1F0K_B The 1.9 Angstrom Crystal Structure Of E. Coli Murg [Escherichia coli],1NLM_A Crystal Structure Of Murg:glcnac Complex [Escherichia coli],1NLM_B Crystal Structure Of Murg:glcnac Complex [Escherichia coli]
7D1I_A 1.14e-31 17 360 7 324
ChainA, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_B Chain B, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii],7D1I_C Chain C, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [Acinetobacter baumannii]
3S2U_A 1.03e-29 19 376 2 328
Crystalstructure of the Pseudomonas aeruginosa MurG:UDP-GlcNAc substrate complex [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits      download full data without filtering help

Created with Snap2040618110212214216318320422424426528530632634636738716408sp|A1A2E9|MURG_BIFAA21404sp|B3DQN1|MURG_BIFLD21404sp|Q8CY50|MURG_BIFLO21404sp|B7GQ78|MURG_BIFLS23399sp|B0RIJ3|MURG_CLAMS
Hit ID E-Value Query Start Query End Hit Start Hit End Description
A1A2E9 5.35e-284 16 408 1 393
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a) OX=367928 GN=murG PE=3 SV=1
B3DQN1 2.89e-198 21 404 7 390
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bifidobacterium longum (strain DJO10A) OX=205913 GN=murG PE=3 SV=1
Q8CY50 2.89e-198 21 404 7 390
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=murG PE=3 SV=1
B7GQ78 3.35e-197 21 404 7 390
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12) OX=391904 GN=murG PE=3 SV=1
B0RIJ3 9.58e-104 23 399 5 352
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase OS=Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1) OX=31964 GN=murG PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000059 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002395_01248.