dbCAN-seq: a database of CAZyme sequence and annotation

You are browsing environment: HUMAN GUT

help

CAZyme Information: MGYG000002404_00142

You are here: Home > Sequence: MGYG000002404_00142

Basic Information help

Species

Bacillus_BE massilionigeriensis

Lineage

Bacteria; Firmicutes; Bacilli; Bacillales_B; DSM-18226; Bacillus_BE; Bacillus_BE massilionigeriensis

CAZyme ID

MGYG000002404_00142

CAZy Family

CBM50

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
464		51040.1	9.9065

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002404	4212889	Isolate	not provided	not provided

Gene Location

Start: 142640; End: 144034 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002404_00142.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam05105	Phage_holin_4_1	8.64e-46	29	132	6	109	Bacteriophage holin family. Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.
cd06583	PGRP	2.44e-27	159	289	2	117	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity.
COG4824	COG4824	4.78e-27	35	133	30	127	Phage-related holin (Lysis protein) [Mobilome: prophages, transposons].
TIGR01593	holin_tox_secr	7.47e-25	35	133	22	120	toxin secretion/phage lysis holin. This model describes one of the many mutally dissimilar families of holins, phage proteins that act together with lytic enzymes in bacterial lysis. This family includes, besides phage holins, the protein TcdE/UtxA involved in toxin secretion in Clostridium difficile and related species. [Protein fate, Protein and peptide secretion and trafficking, Mobile and extrachromosomal element functions, Prophage functions]
pfam01510	Amidase_2	9.69e-19	158	287	1	112	N-acetylmuramoyl-L-alanine amidase. This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AST58407.1	1.97e-149	138	437	1	293
CUH93073.1	5.63e-149	138	437	1	293
AUS97328.1	2.27e-148	138	437	1	293
AEV70121.1	3.22e-148	138	437	1	293
AEV70155.1	6.48e-148	138	437	1	293

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3HMB_A	4.93e-12	154	285	21	133	ChainA, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_B Chain B, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis],3HMB_C Chain C, N-acetylmuramoyl-L-alanine amidase xlyA [Bacillus subtilis]
3RDR_A	4.25e-11	154	285	21	133	Structureof the catalytic domain of XlyA [Bacillus subtilis]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P26835	3.94e-23	14	133	12	131	Uncharacterized 14.9 kDa protein in nagH 3'region OS=Clostridium perfringens OX=1502 PE=3 SV=1
P58701	3.71e-21	8	133	6	131	Uncharacterized protein CPE0383 OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=CPE0383 PE=3 SV=1
Q92FD1	4.24e-21	8	127	3	121	Uncharacterized protein Lin0175 OS=Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) OX=272626 GN=lin0175 PE=3 SV=1
P58702	4.24e-21	8	127	3	121	Uncharacterized protein Lmo0128 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) OX=169963 GN=lmo0128 PE=3 SV=1
Q9KE91	1.85e-17	35	132	30	131	Uncharacterized protein BH0965 OS=Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) OX=272558 GN=BH0965 PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000030	0.000000	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations download full data without filtering help

start	end
7	26
30	52
64	81