CAZyme Information: MGYG000002452_00256

Basic Information

• Species: Akkermansia muciniphila_C
• Lineage: Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia muciniphila_C
• CAZyme ID: MGYG000002452_00256
• CAZy Family: GH18
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
1228		132012.45	4.797

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002452	2902150	Isolate	China	Asia

• Gene Location: Start: 304377; End: 308063 Strand: +

Full Sequence      

MKKKSLFGVLVAVALSALGNPGQGAGTVESFGVDFGNAASAAQPGWTNMGVVTVTPSSTL
KSVPLRRNNLEASSSPVLAGTLFGRSVYLAVTAKSEASVGNMCYNNANSTWREKGETRGG
QPGGVLQAESAFSFPNHGEALNTSLQLFTNGMAVRAGTVRVSLSGLQPGKEYSVSFFLGS
GKPAYQSVYLVSGAHVDVKALQTSTGSRTEEMWKGGVNTADADTYMAVEWTAAADEAGTL
VFDVVKEGNSAGTGALNLNALTVRTDDTPAPPAPEPKPVSVLHNRALTVLPSPVALPVPA
DAWTGTGEMTCELWVRPDGDAASGAILSLGASTLSLNAGRLHLESGNAEAPASVEASGQP
FAAGTWHHVAVALGTENVSLYVDGTLAGTAPAAPYLASMKNGWTGLVLAAQFKGARDELR
FWNAELGTGADDFFLTGPLPMAHPRYGRLVGLWRLDGDFRDAKWTEFADKTGSSFTRPYQ
AVTPSGTEFSIVTDNNTFRYMLMTAYVRDSHLRYHWLSRSHIINNNDLIYIGVTGLTADG
TITHWRPDNDVKEKNGVTFLPREGTRTSIYRFTGPNASMRVGGGLLGGDPAAFTIEADML
LSAERENFILFGNDNVSLTISWAADHYRARIQVGTSKAWEADLPDILLNEYFWIAFVRNN
DTGTFYLNNTAVETVAAAAGNDLDSQTANAVVGSNLVGNIDEMRIWVEARAAGKLGKAVQ
HAWADRQIVAYWGDSDVEDYDTASWVSDLRYLRELTAEVEGINIRLCVSGGSDWKKMLGN
EAARNKFATQIAEMLNEYGDLLDGVDLDFEWLYQGDSLWNGYGALAEAIRQKIGSGPVFT
ITLHTVAYWFPKDKIQFVDFFPFQNYGPSSSAGTYNTMVSACNLFRSWGYPDSKIQLSGP
FYGVTGASGATDAMLYRDLKGEEELNDPALDQLTLNSNGKKYYYNGVDTTRKKNKYISDQ
KLAGFMYWDLGGDISDSRNESNYFDQRSLLRAANRYVSSTSFPVTASPFGLSRVGASVPA
AGGPVDVEVQMEEEALGWVVAESPEWISVSASSGMGRTTVILTASENKSAAGRSGTVVFR
ASDKQECAVTVTQAGADLAGYDKWVQDTFPPDATADRTAADASPAGDGVTNLMKYATGLD
PLKPCGSVTKVSVEEGADGNRHLVLRWPVNPQAAEVKHEVEVSPDLVSWISLGEVETAGK
TSAEFRDAEPVQESGMKRRFLRLKVTRE

Enzyme Prediction     

No EC number prediction in MGYG000002452_00256.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH18	758	984	8.5e-26	0.8006756756756757

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
pfam00704	Glyco_hydro_18	7.60e-19	763	973	63	307	Glycosyl hydrolases family 18.
smart00636	Glyco_18	5.20e-18	751	973	56	334	Glyco_18 domain.
cd14948	BACON	5.41e-14	1017	1094	10	83	Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.
pfam13385	Laminin_G_3	5.89e-13	305	426	15	145	Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.
cd06548	GH18_chitinase	3.09e-11	730	973	53	322	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QHV76541.1	0.0	1	1228	36	1270
QUY60491.1	0.0	1	1228	36	1270
QWP73184.1	0.0	1	1228	1	1235
QHV64174.1	0.0	1	1228	36	1270
QWP63366.1	0.0	1	1228	1	1235

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5GZU_A	9.85e-07	747	1001	95	404	CrystalStructure of Chitinase ChiW from Paenibacillus sp. str. FPU-7 Reveals a Novel Type of Bacterial Cell-Surface-Expressed Multi-Modular Enzyme Machinery [Paenibacillus sp. FPU-7],5GZU_B Crystal Structure of Chitinase ChiW from Paenibacillus sp. str. FPU-7 Reveals a Novel Type of Bacterial Cell-Surface-Expressed Multi-Modular Enzyme Machinery [Paenibacillus sp. FPU-7],5GZV_A Crystal Structure of Chitinase ChiW from Paenibacillus sp. str. FPU-7 Reveals a Novel Type of Bacterial Cell-Surface-Expressed Multi-Modular Enzyme Machinery [Paenibacillus sp. FPU-7],5GZV_B Crystal Structure of Chitinase ChiW from Paenibacillus sp. str. FPU-7 Reveals a Novel Type of Bacterial Cell-Surface-Expressed Multi-Modular Enzyme Machinery [Paenibacillus sp. FPU-7]
5GZT_B	1.06e-06	747	1001	346	655	CrystalStructure of Chitinase ChiW from Paenibacillus sp. str. FPU-7 Reveals a Novel Type of Bacterial Cell-Surface-Expressed Multi-Modular Enzyme Machinery [Paenibacillus sp. FPU-7]

Swiss-Prot Hits     

has no Swissprot hit.

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000882	0.635350	0.363038	0.000243	0.000254	0.000210

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002452_00256.