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CAZyme Information: MGYG000002453_01859
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Akkermansia muciniphila_B | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales; Akkermansiaceae; Akkermansia; Akkermansia muciniphila_B | |||||||||||
| CAZyme ID | MGYG000002453_01859 | |||||||||||
| CAZy Family | GH37 | |||||||||||
| CAZyme Description | Cytoplasmic trehalase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 244400; End: 245926 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH37 | 235 | 421 | 2.3e-24 | 0.35845213849287166 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam03200 | Glyco_hydro_63 | 2.08e-22 | 134 | 423 | 156 | 487 | Glycosyl hydrolase family 63 C-terminal domain. This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyze the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain. |
| PRK10137 | PRK10137 | 3.40e-19 | 84 | 380 | 382 | 741 | alpha-glucosidase; Provisional |
| COG3408 | GDB1 | 1.45e-17 | 71 | 472 | 275 | 641 | Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism]. |
| pfam01204 | Trehalase | 5.57e-17 | 238 | 386 | 318 | 463 | Trehalase. Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with pfam07492 in fungi. |
| COG1626 | TreA | 1.38e-12 | 202 | 389 | 325 | 512 | Neutral trehalase [Carbohydrate transport and metabolism]. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QWP49634.1 | 0.0 | 1 | 508 | 1 | 508 |
| QHV75040.1 | 0.0 | 1 | 508 | 25 | 532 |
| QUY58994.1 | 0.0 | 1 | 508 | 25 | 532 |
| QHV62672.1 | 0.0 | 1 | 508 | 25 | 532 |
| QWP74499.1 | 0.0 | 16 | 508 | 1 | 493 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3W7S_A | 1.08e-13 | 225 | 380 | 551 | 714 | Escherichiacoli K12 YgjK complexed with glucose [Escherichia coli K-12],3W7S_B Escherichia coli K12 YgjK complexed with glucose [Escherichia coli K-12],3W7T_A Escherichia coli K12 YgjK complexed with mannose [Escherichia coli K-12],3W7T_B Escherichia coli K12 YgjK complexed with mannose [Escherichia coli K-12],3W7U_A Escherichia coli K12 YgjK complexed with galactose [Escherichia coli K-12],3W7U_B Escherichia coli K12 YgjK complexed with galactose [Escherichia coli K-12] |
| 3W7X_A | 1.08e-13 | 225 | 380 | 551 | 714 | Crystalstructure of E. coli YgjK D324N complexed with melibiose [Escherichia coli K-12],3W7X_B Crystal structure of E. coli YgjK D324N complexed with melibiose [Escherichia coli K-12],5CA3_A Crystal structure of the glycosynthase mutant D324N of Escherichia coli GH63 glycosidase in complex with glucose and lactose [Escherichia coli K-12],5CA3_B Crystal structure of the glycosynthase mutant D324N of Escherichia coli GH63 glycosidase in complex with glucose and lactose [Escherichia coli K-12] |
| 3W7W_A | 1.08e-13 | 225 | 380 | 551 | 714 | Crystalstructure of E. coli YgjK E727A complexed with 2-O-alpha-D-glucopyranosyl-alpha-D-galactopyranose [Escherichia coli K-12],3W7W_B Crystal structure of E. coli YgjK E727A complexed with 2-O-alpha-D-glucopyranosyl-alpha-D-galactopyranose [Escherichia coli K-12],5GW7_A Crystal structure of the glycosynthase mutant E727A of Escherichia coli GH63 glycosidase in complex with glucose and lactose [Escherichia coli K-12],5GW7_B Crystal structure of the glycosynthase mutant E727A of Escherichia coli GH63 glycosidase in complex with glucose and lactose [Escherichia coli K-12] |
| 7PQQ_B | 1.19e-13 | 225 | 380 | 100 | 263 | ChainB, Anti-RON nanobody,Megabody 91,Glucosidase YgjK [Lama glama] |
| 6XUX_A | 1.19e-13 | 225 | 380 | 100 | 263 | ChainA, Nanobody,Glucosidase YgjK,Glucosidase YgjK,Nanobody [Escherichia coli K-12] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P94250 | 1.61e-37 | 37 | 450 | 3 | 407 | Uncharacterized protein BB_0381 OS=Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31) OX=224326 GN=BB_0381 PE=4 SV=2 |
| P42592 | 6.04e-13 | 225 | 380 | 574 | 737 | Glucosidase YgjK OS=Escherichia coli (strain K12) OX=83333 GN=ygjK PE=1 SV=1 |
| P49381 | 3.90e-11 | 254 | 389 | 534 | 673 | Cytosolic neutral trehalase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) OX=284590 GN=NTH1 PE=1 SV=1 |
| O42622 | 2.70e-10 | 237 | 389 | 500 | 654 | Cytosolic neutral trehalase OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) OX=242507 GN=NTH1 PE=2 SV=2 |
| J5K1E2 | 4.74e-10 | 246 | 389 | 514 | 661 | Cytosolic neutral trehalase OS=Beauveria bassiana (strain ARSEF 2860) OX=655819 GN=NTH1 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as LIPO
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.001905 | 0.272247 | 0.725101 | 0.000298 | 0.000223 | 0.000209 |