dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002455_03754

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Basic Information help

Species

Bacteroides cellulosilyticus

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides cellulosilyticus

CAZyme ID

MGYG000002455_03754

CAZy Family

GH117

CAZyme Description

Arylsulfatase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
483	MGYG000002455_17\|CGC1	54006.04	5.0587

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002455	6974062	Isolate	United States	North America

Gene Location

Start: 81961; End: 83412 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002455_03754.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd16026	GALNS_like	0.0	33	413	1	398	galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS). Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
cd16144	ARS_like	4.40e-133	34	431	1	421	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16142	ARS_like	5.88e-131	34	413	1	371	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16158	ARSA	2.13e-129	33	413	1	422	Arylsulfatase A or cerebroside-sulfatase. Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
cd16143	ARS_like	5.99e-123	34	414	1	395	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QDH57428.1	2.34e-113	32	431	21	456
QNN23223.1	1.28e-108	10	441	13	437
VTR91273.1	1.63e-100	31	437	21	455
QDT95903.1	7.53e-96	19	438	23	466
QDU36023.1	7.02e-95	24	437	30	478

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1E1Z_P	4.31e-92	32	430	1	440	Crystalstructure of an Arylsulfatase A mutant C69S [Homo sapiens]
1E3C_P	4.31e-92	32	430	1	440	Crystalstructure of an Arylsulfatase A mutant C69S soaked in synthetic substrate [Homo sapiens]
1E2S_P	1.21e-91	32	430	1	440	Crystalstructure of an Arylsulfatase A mutant C69A [Homo sapiens]
1E33_P	2.39e-91	32	430	1	440	Crystalstructure of an Arylsulfatase A mutant P426L [Homo sapiens]
1AUK_A	2.39e-91	32	430	1	440	HumanArylsulfatase A [Homo sapiens],1N2K_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens],1N2L_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P15289	1.53e-90	31	430	18	458	Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3
P50428	1.19e-85	16	429	3	456	Arylsulfatase A OS=Mus musculus OX=10090 GN=Arsa PE=1 SV=2
Q08DD1	3.42e-85	31	430	18	458	Arylsulfatase A OS=Bos taurus OX=9913 GN=ARSA PE=2 SV=1
Q32KH5	3.47e-77	32	432	28	469	N-acetylgalactosamine-6-sulfatase OS=Canis lupus familiaris OX=9615 GN=GALNS PE=2 SV=1
Q8WNQ7	1.35e-76	15	413	15	454	N-acetylgalactosamine-6-sulfatase OS=Sus scrofa OX=9823 GN=GALNS PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.002026	0.752848	0.244040	0.000528	0.000276	0.000242

TMHMM Annotations help

There is no transmembrane helices in MGYG000002455_03754.