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CAZyme Information: MGYG000002463_01134

You are here: Home > Sequence: MGYG000002463_01134

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Pseudomonas aeruginosa
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; Pseudomonas aeruginosa
CAZyme ID MGYG000002463_01134
CAZy Family CBM32
CAZyme Description Non-hemolytic phospholipase C
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
730 MGYG000002463_4|CGC2 82653.27 6.508
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002463 6750396 Isolate Brazil South America
Gene Location Start: 157387;  End: 159579  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002463_01134.

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG3511 PlcC 0.0 4 565 1 527
Phospholipase C [Cell wall/membrane/envelope biogenesis].
TIGR03396 PC_PLC 0.0 9 726 2 689
phospholipase C, phosphocholine-specific, Pseudomonas-type. Members of this protein family are bacterial, phosphatidylcholine-hydrolyzing phospholipase C enzymes, with a characteristic domain architecture as found in hemolytyic (PlcH) and nonhemolytic (PlcN) secreted enzymes of Pseudomonas aeruginosa. PlcH hydrolyzes phosphatidylcholine to diacylglycerol and phosphocholine, but unlike PlcN can also hydrolyze sphingomyelin to ceramide ((N-acylsphingosine)) and phosphocholine. Members of this family share the twin-arginine signal sequence for Sec-independent transport across the plasma membrane. PlcH is secreted as a heterodimer with a small chaperone, PlcR, encoded immediately downstream. [Cellular processes, Pathogenesis]
pfam04185 Phosphoesterase 2.98e-144 51 436 1 347
Phosphoesterase family. This family includes both bacterial phospholipase C enzymes EC:3.1.4.3, but also eukaryotic acid phosphatases EC:3.1.3.2.
cd16014 PLC 1.23e-127 51 436 1 286
non-hemolytic phospholipase C. Nonhemolytic Phospholipases C is produced by pathogenic bacterial. The toxic phospholipases C can interact with eukaryotic cell membranes and hydrolyze phosphatidylcholine and sphingomyelin, leading to cell lysis.
cd16013 AcpA 2.68e-76 51 435 3 365
acid phosphatase A. Acid phosphatase A catalyzes the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at low pH. AcpA hydrolyzes a variety of substrates, including p-nitrophenylphosphate (pNPP), p-nitrophenylphosphorylcholine (pNPPC), peptides containing phosphotyrosine, inositol phosphates, AMP, ATP, fructose 1,6-bisphosphate, glucose and fructose 6-phosphates, NADP, and ribose 5-phosphate. AcpA is distinct from histidine ACPs and purple ACPs, as well as class A, B, and C bacterial nonspecific ACPs.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QKW17792.1 1.01e-145 9 723 11 672
ACU76193.1 2.63e-145 9 719 6 647
QWF84028.1 9.71e-134 8 730 2 705
ANN20098.1 8.13e-132 8 725 2 698
QXV59370.1 3.09e-131 8 725 2 697

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2D1G_A 9.78e-17 47 458 30 470
ChainA, acid phosphatase [Francisella tularensis subsp. novicida],2D1G_B Chain B, acid phosphatase [Francisella tularensis subsp. novicida]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P06200 0.0 1 730 1 730
Hemolytic phospholipase C OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=plcH PE=3 SV=2
Q9RGS8 1.47e-177 9 728 6 700
Non-hemolytic phospholipase C OS=Burkholderia pseudomallei (strain K96243) OX=272560 GN=plcN PE=1 SV=2
P15713 7.28e-167 9 723 6 683
Non-hemolytic phospholipase C OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=plcN PE=3 SV=2
P9WIB3 2.97e-79 9 517 12 517
Phospholipase C B OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=plcB PE=1 SV=1
P9WIB2 2.97e-79 9 517 12 517
Phospholipase C B OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) OX=83331 GN=plcB PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as TAT

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000001 0.000003 0.000000 0.999821 0.000176 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002463_01134.