CAZyme Information: MGYG000002485_00807

Basic Information

• Species: Fusobacterium_A mortiferum
• Lineage: Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae; Fusobacterium_A; Fusobacterium_A mortiferum
• CAZyme ID: MGYG000002485_00807
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
747	MGYG000002485_1|CGC13	86753.57	9.4521

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002485	2635424	Isolate	not provided	not provided

• Gene Location: Start: 852643; End: 854886 Strand: +

Full Sequence      

MRKLRFLPLILIIPIIFCIKIYSEFDIEKMRDEIEKRYSQVVLDDRDNIIGAYLNSEEQW
QIKGVEIPPRLKLAVLNYEDRKFYSHNGVDYLAIVRAVKTNLLEKRRVGASTITMQGVKL
YKRRERTYLSKIEEIIESYKLEKYLSKDEILELYLNNAPYGSNIVGYETASQLYFGKSAK
NLTWAEGATLAVLPNSPGLIWIEKNRDKLLNKRDNLLKSMYERGVIDEKQYRLSIKEELP
KERKYFNSLAPHLTRRLVNEYDDKIIKSTINSELQKNIERIAREYGDYLNNRGIKNTAII
VVDNHSGEVKSYVGSQNFYDFQRNGQVDGVVAQRSVGSVLKPFLYALSIDEGLITPKSKL
LDVPLYFSNFNPQNANKKYQGLVEARESLKKSLNIPFVKLLDEYGVDKFFYFLKDVINFP
ERDYSNYGLSLILGTKEMSIENIAKLYYGLSQYGEFKDLKYIRDDKKIDGRKLISKGASY
LTLEAMQGVQRYGIDNLYLGRDGIAWKTGTSYGQRDAWAGGISPRWTVVVWCGNFTGEGN
RNISGVVTAGQLLFKIFKVLPNENESFIKPSEELKKVEIDSETGYRLRYDVPSEEIDYPK
DAKSLKVSPYYKKVFINSKGEEIDSRNEEFIESKEKIVLSYPIELLDYMARENISISNVR
DEKIKIIYPLNNIKIFLPKDFEERKSLIVKVANPKNKKLYWYHNGKYIFSGRDRERAFDF
LEGEHRLTLVSESGEVVEVKFYILRGK

Enzyme Prediction     

No EC number prediction in MGYG000002485_00807.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	55	221	5.2e-51	0.9491525423728814

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG4953	PbpC	0.0	38	745	35	733	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
TIGR02073	PBP_1c	0.0	35	743	7	726	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	2.21e-107	31	534	47	571	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
PRK11240	PRK11240	2.69e-107	66	533	69	535	penicillin-binding protein 1C; Provisional
TIGR02074	PBP_1a_fam	2.09e-97	66	534	9	501	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AVQ18978.1	0.0	1	747	1	747
QNM15576.1	0.0	4	747	8	750
SQJ06920.1	0.0	22	747	23	754
AVQ26788.1	0.0	22	747	23	754
BBA50599.1	0.0	15	747	16	754

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5FGZ_A	1.26e-32	55	533	152	667	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	1.35e-32	55	533	173	688	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
2JE5_A	6.26e-32	47	544	41	614	StructuralAnd Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6],2JE5_B Structural And Mechanistic Basis Of Penicillin Binding Protein Inhibition By Lactivicins [Streptococcus pneumoniae R6]
3UDF_A	1.12e-30	47	546	27	702	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3FWL_A	1.19e-30	55	533	156	671	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	1.46e-78	66	560	71	564	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	2.86e-51	39	578	49	614	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
A7GHV1	2.51e-45	41	558	58	641	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A7FY32	6.21e-45	41	558	58	641	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	6.21e-45	41	558	58	641	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.428038	0.224579	0.341344	0.000968	0.000743	0.004324

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002485_00807.