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CAZyme Information: MGYG000002490_00552
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Paenibacillus_B thiaminolyticus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Paenibacillales; Paenibacillaceae; Paenibacillus_B; Paenibacillus_B thiaminolyticus | |||||||||||
| CAZyme ID | MGYG000002490_00552 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Gramicidin S synthase 2 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 101653; End: 108195 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK12316 | PRK12316 | 0.0 | 885 | 1897 | 42 | 1058 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 1 | 1208 | 2780 | 3961 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 1 | 870 | 4273 | 5137 | peptide synthase; Provisional |
| PRK12316 | PRK12316 | 0.0 | 1 | 1921 | 1727 | 3619 | peptide synthase; Provisional |
| cd17651 | A_NRPS_VisG_like | 0.0 | 284 | 787 | 1 | 491 | similar to adenylation domain of virginiamycin S synthetase. This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 0.0 | 46 | 2042 | 778 | 2784 |
| BAY90071.1 | 5.94e-277 | 1 | 2042 | 306 | 3404 |
| BAZ00088.1 | 4.16e-269 | 11 | 2042 | 317 | 3413 |
| BAZ75991.1 | 4.16e-269 | 11 | 2042 | 317 | 3413 |
| BAY30132.1 | 7.93e-269 | 11 | 2042 | 317 | 3415 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6MFY_A | 0.0 | 275 | 1851 | 202 | 1725 | Crystalstructure of a 5-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis],6MG0_A Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis],6MG0_B Crystal structure of a 5-domain construct of LgrA in the thiolation state [Brevibacillus parabrevis] |
| 6MFZ_A | 0.0 | 275 | 1921 | 202 | 1794 | Crystalstructure of dimodular LgrA in a condensation state [Brevibacillus parabrevis],6MFZ_B Crystal structure of dimodular LgrA in a condensation state [Brevibacillus parabrevis] |
| 5U89_A | 9.50e-220 | 258 | 1323 | 5 | 1071 | Crystalstructure of a cross-module fragment from the dimodular NRPS DhbF [Geobacillus sp. Y4.1MC1] |
| 6P1J_A | 1.07e-218 | 893 | 1838 | 6 | 964 | Thestructure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae],6P1J_B The structure of condensation and adenylation domains of teixobactin-producing nonribosomal peptide synthetase Txo2 serine module [Eleftheria terrae] |
| 6MFW_A | 2.99e-217 | 275 | 1318 | 202 | 1205 | Crystalstructure of a 4-domain construct of LgrA in the substrate donation state [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P45745 | 0.0 | 4 | 2043 | 190 | 2229 | Dimodular nonribosomal peptide synthase OS=Bacillus subtilis (strain 168) OX=224308 GN=dhbF PE=1 SV=4 |
| Q70LM4 | 0.0 | 1 | 1928 | 185 | 2096 | Linear gramicidin synthase subunit D OS=Brevibacillus parabrevis OX=54914 GN=lgrD PE=1 SV=1 |
| Q04747 | 0.0 | 2 | 1921 | 1223 | 3101 | Surfactin synthase subunit 2 OS=Bacillus subtilis (strain 168) OX=224308 GN=srfAB PE=1 SV=3 |
| P94459 | 0.0 | 7 | 1921 | 1222 | 3101 | Plipastatin synthase subunit D OS=Bacillus subtilis (strain 168) OX=224308 GN=ppsD PE=1 SV=2 |
| Q70LM5 | 0.0 | 1 | 1921 | 5363 | 7267 | Linear gramicidin synthase subunit C OS=Brevibacillus parabrevis OX=54914 GN=lgrC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000064 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |