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CAZyme Information: MGYG000002501_01811
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Enterobacter cloacae_K | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Enterobacter; Enterobacter cloacae_K | |||||||||||
| CAZyme ID | MGYG000002501_01811 | |||||||||||
| CAZy Family | AA3 | |||||||||||
| CAZyme Description | Oxygen-dependent choline dehydrogenase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 139884; End: 141548 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| AA3 | 2 | 532 | 2.6e-165 | 0.9929577464788732 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| COG2303 | BetA | 0.0 | 1 | 538 | 6 | 540 | Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]. |
| PRK02106 | PRK02106 | 0.0 | 1 | 554 | 4 | 554 | choline dehydrogenase; Validated |
| TIGR01810 | betA | 0.0 | 4 | 537 | 1 | 532 | choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions] |
| TIGR03970 | Rv0697 | 6.48e-89 | 4 | 532 | 2 | 487 | dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. |
| pfam00732 | GMC_oxred_N | 1.18e-72 | 73 | 301 | 15 | 218 | GMC oxidoreductase. This family of proteins bind FAD as a cofactor. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAB3230510.1 | 7.06e-186 | 2 | 546 | 24 | 570 |
| AWP09430.1 | 4.46e-183 | 2 | 545 | 19 | 564 |
| ANI26486.1 | 1.21e-182 | 2 | 545 | 70 | 615 |
| CEF60566.1 | 9.01e-160 | 5 | 544 | 35 | 581 |
| CAG5086058.1 | 6.78e-159 | 1 | 548 | 13 | 580 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 3LJP_A | 1.26e-89 | 2 | 542 | 13 | 537 | ChainA, Choline oxidase [Arthrobacter globiformis],3LJP_B Chain B, Choline oxidase [Arthrobacter globiformis] |
| 2JBV_A | 4.89e-89 | 2 | 542 | 13 | 537 | Crystalstructure of choline oxidase reveals insights into the catalytic mechanism [Arthrobacter globiformis],2JBV_B Crystal structure of choline oxidase reveals insights into the catalytic mechanism [Arthrobacter globiformis],4MJW_A Crystal Structure of Choline Oxidase in Complex with the Reaction Product Glycine Betaine [Arthrobacter globiformis],4MJW_B Crystal Structure of Choline Oxidase in Complex with the Reaction Product Glycine Betaine [Arthrobacter globiformis] |
| 3NNE_A | 4.89e-89 | 2 | 542 | 13 | 537 | Crystalstructure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_B Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_C Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_D Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_E Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_F Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_G Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis],3NNE_H Crystal structure of choline oxidase S101A mutant [Arthrobacter globiformis] |
| 6YRU_AAA | 8.10e-78 | 2 | 543 | 7 | 572 | ChainAAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRV_AAA Chain AAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRX_AAA Chain AAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRZ_AAA Chain AAA, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis] |
| 6ZH7_A | 8.10e-78 | 2 | 543 | 7 | 572 | ChainA, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis],6ZH7_B Chain B, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| B7N8L3 | 0.0 | 1 | 553 | 1 | 553 | Oxygen-dependent choline dehydrogenase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) OX=585056 GN=betA PE=3 SV=1 |
| P17444 | 0.0 | 1 | 553 | 1 | 553 | Oxygen-dependent choline dehydrogenase OS=Escherichia coli (strain K12) OX=83333 GN=betA PE=1 SV=1 |
| B7V5R3 | 0.0 | 2 | 553 | 4 | 555 | Oxygen-dependent choline dehydrogenase OS=Pseudomonas aeruginosa (strain LESB58) OX=557722 GN=betA PE=3 SV=1 |
| B7UJG4 | 0.0 | 1 | 553 | 1 | 553 | Oxygen-dependent choline dehydrogenase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) OX=574521 GN=betA PE=3 SV=1 |
| Q02DZ0 | 0.0 | 2 | 553 | 4 | 555 | Oxygen-dependent choline dehydrogenase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) OX=208963 GN=betA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000049 | 0.000009 | 0.000001 | 0.000000 | 0.000000 | 0.000000 |