dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002508_01966

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Basic Information help

Species

Hafnia alvei

Lineage

Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Hafnia; Hafnia alvei

CAZyme ID

MGYG000002508_01966

CAZy Family

GH23

CAZyme Description

Membrane-bound lytic murein transglycosylase F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
480	MGYG000002508_1\|CGC18	54008.46	9.8729

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002508	4498956	Isolate	South Korea	Asia

Gene Location

Start: 2112778; End: 2114220 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002508_01966.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH23	318	462	2.7e-20	0.8592592592592593

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd13403	MLTF-like	2.25e-71	310	457	1	159	membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
COG4623	MltF	1.34e-64	37	458	14	435	Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
cd01009	PBP2_YfhD_N	8.14e-63	46	285	1	222	The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
PRK10859	PRK10859	1.84e-57	39	454	36	447	membrane-bound lytic murein transglycosylase MltF.
pfam00497	SBP_bac_3	8.74e-28	58	264	12	203	Bacterial extracellular solute-binding proteins, family 3.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
AWV44845.1	1	480	1	480
AIU72748.1	1	480	1	480
QIP55903.1	1	480	1	480
QBJ33216.1	1	480	1	480
ANC42127.1	1	480	1	480

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5TUJ_C	1.02e-12	40	271	6	221	AncestralCationic Amino Acid Solute Binding Protein (AncCDT-1) [unidentified]
5T0W_A	1.22e-12	40	271	17	232	Crystalstructure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_B Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_C Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_D Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct]
4ZV1_A	9.02e-11	58	264	23	211	Anancestral arginine-binding protein bound to arginine [synthetic construct],4ZV2_A An ancestral arginine-binding protein bound to glutamine [synthetic construct]
2Y7I_A	3.10e-09	78	280	31	223	ChainA, Stm4351 [Salmonella enterica subsp. enterica serovar Typhimurium],2Y7I_B Chain B, Stm4351 [Salmonella enterica subsp. enterica serovar Typhimurium]
1XT8_A	1.42e-07	31	259	33	239	ChainA, putative amino-acid transporter periplasmic solute-binding protein [Campylobacter jejuni],1XT8_B Chain B, putative amino-acid transporter periplasmic solute-binding protein [Campylobacter jejuni]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A8ZWR8	5.68e-39	42	454	37	445	Membrane-bound lytic murein transglycosylase F OS=Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3) OX=96561 GN=mltF PE=3 SV=2
Q4KHS7	1.78e-31	40	469	35	463	Membrane-bound lytic murein transglycosylase F OS=Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) OX=220664 GN=mltF PE=3 SV=2
Q47XX8	2.92e-29	45	471	35	454	Membrane-bound lytic murein transglycosylase F OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) OX=167879 GN=mltF PE=3 SV=2
Q3KHL5	3.42e-29	14	469	16	463	Membrane-bound lytic murein transglycosylase F OS=Pseudomonas fluorescens (strain Pf0-1) OX=205922 GN=mltF PE=3 SV=1
A6WQN7	7.76e-29	1	476	1	456	Membrane-bound lytic murein transglycosylase F OS=Shewanella baltica (strain OS185) OX=402882 GN=mltF PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000212	0.999201	0.000146	0.000154	0.000139	0.000134

TMHMM Annotations help

There is no transmembrane helices in MGYG000002508_01966.