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CAZyme Information: MGYG000002518_03838

You are here: Home > Sequence: MGYG000002518_03838

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Serratia surfactantfaciens
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Serratia; Serratia surfactantfaciens
CAZyme ID MGYG000002518_03838
CAZy Family GH18
CAZyme Description Chitinase B
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
499 MGYG000002518_23|CGC1 55445.56 6.6936
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002518 5076569 Isolate India Asia
Gene Location Start: 10162;  End: 11661  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 3.2.1.14 3.2.1.-

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 4 416 6.4e-79 0.9662162162162162

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
smart00636 Glyco_18 1.13e-109 7 408 2 334
Glyco_18 domain.
cd06548 GH18_chitinase 2.77e-104 7 408 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
COG3325 ChiA 5.13e-83 41 418 62 432
Chitinase, GH18 family [Carbohydrate transport and metabolism].
pfam00704 Glyco_hydro_18 1.07e-79 40 408 19 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 1.35e-72 31 412 18 345
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
AFU06779.1 0.0 1 498 1 498
QWU36245.1 0.0 1 498 1 498
ALD45820.1 0.0 1 498 1 498
AIM23063.1 0.0 1 498 1 498
ASM13208.1 0.0 1 498 1 498

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6JK9_A 0.0 3 498 1 496
Crystalstructure of Serratia marcescens Chitinase B complexed with compound 2-8-14 [Serratia marcescens],6JK9_B Crystal structure of Serratia marcescens Chitinase B complexed with compound 2-8-14 [Serratia marcescens],7C34_A Crystal structure of Serratia marcescens Chitinase B complexed with Berberine [Serratia marcescens],7C34_B Crystal structure of Serratia marcescens Chitinase B complexed with Berberine [Serratia marcescens]
1OGB_A 0.0 1 498 1 498
Chitinaseb from Serratia marcescens mutant D142N [Serratia marcescens],1OGB_B Chitinase b from Serratia marcescens mutant D142N [Serratia marcescens],1OGG_A chitinase b from serratia marcescens mutant d142n in complex with inhibitor allosamidin [Serratia marcescens],1OGG_B chitinase b from serratia marcescens mutant d142n in complex with inhibitor allosamidin [Serratia marcescens]
1UR9_A 0.0 1 498 1 498
Interactionsof a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone [Serratia marcescens],1UR9_B Interactions of a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone [Serratia marcescens]
3WD0_A 0.0 2 498 6 502
Serratiamarcescens Chitinase B, tetragonal form [Serratia marcescens],3WD1_A Serratia marcescens Chitinase B complexed with syn-triazole inhibitor [Serratia marcescens],3WD2_A Serratia marcescens Chitinase B complexed with azide inhibitor [Serratia marcescens],3WD3_A Serratia marcescens Chitinase B complexed with azide inhibitor [Serratia marcescens],3WD4_A Serratia marcescens Chitinase B complexed with azide inhibitor and quinoline compound [Serratia marcescens],4Z2G_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 26 [Serratia marcescens],4Z2H_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 29 [Serratia marcescens],4Z2I_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 30 [Serratia marcescens],4Z2J_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 31 [Serratia marcescens],4Z2K_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 32 [Serratia marcescens],4Z2L_A Serratia marcescens Chitinase B complexed with macrolide inhibitor 33 [Serratia marcescens]
7C92_A 0.0 2 498 6 502
ChainA, Chitinase [Serratia marcescens],7C92_B Chain B, Chitinase [Serratia marcescens]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P11797 0.0 1 498 1 498
Chitinase B OS=Serratia marcescens OX=615 GN=chiB PE=1 SV=1
P20533 2.77e-56 75 478 142 488
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
Q92222 1.13e-42 41 433 27 389
Endochitinase B OS=Emericella nidulans OX=162425 GN=chiB PE=1 SV=3
G5EAZ3 1.13e-42 41 433 27 389
Endochitinase B OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=chiB PE=1 SV=1
A6N6J0 4.15e-42 35 433 54 423
Endochitinase 46 OS=Trichoderma harzianum OX=5544 GN=chit46 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000042 0.000003 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002518_03838.