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CAZyme Information: MGYG000002532_01233
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Enterovibrio hollisae | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Vibrionaceae; Enterovibrio; Enterovibrio hollisae | |||||||||||
| CAZyme ID | MGYG000002532_01233 | |||||||||||
| CAZy Family | GT44 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 1351991; End: 1360927 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| NF033479 | Efa1_rel_toxin | 0.0 | 1032 | 2926 | 693 | 2581 | LifA/Efa1-related large cytotoxin. Members of this family are large and almost certainly multifunctional proteins found in various pathogens from genus Chlamydia, about 3000 amino acids in size and related to lymphostatin (Efa1/LifA) from enteropathogenic Escherichia coli. Roles have been suggested for Efa1 (EHEC factor for adherence) in adhesion, so some members have been annotated as adherence proteins rather than cytotoxins. |
| NF033479 | Efa1_rel_toxin | 3.28e-105 | 32 | 621 | 13 | 664 | LifA/Efa1-related large cytotoxin. Members of this family are large and almost certainly multifunctional proteins found in various pathogens from genus Chlamydia, about 3000 amino acids in size and related to lymphostatin (Efa1/LifA) from enteropathogenic Escherichia coli. Roles have been suggested for Efa1 (EHEC factor for adherence) in adhesion, so some members have been annotated as adherence proteins rather than cytotoxins. |
| pfam12919 | TcdA_TcdB | 3.82e-45 | 260 | 616 | 1 | 316 | TcdA/TcdB catalytic glycosyltransferase domain. This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein. |
| cd20495 | C58_PaToxP-like | 1.26e-42 | 784 | 986 | 1 | 179 | peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large cytotoxin, and similar proteins. This subfamily includes the cysteine protease domain of Photorhabdus asymbiotica toxin PaTox, a large virulence-associated multifunctional protein toxin. This domain is similar to AvrPphB protease found in Pseudomonas syringae, a C58 protease. Mutation studies show that this domain enhances cytotoxic effects of the toxin, and therefore is essential for full PaTox activity. Also included in this family is the enteropathogenic Escherichia coli (EPEC) factor for adherence/lymphocyte activation inhibitor (efa1/lifA) gene which is strongly associated with diarrhea. Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. This domain contains the invariant C/H/D residues conserved in the C58/YopT family. |
| cd20495 | C58_PaToxP-like | 3.34e-33 | 1776 | 1952 | 1 | 169 | peptidase C58 domain of Photorhabdus asymbiotica toxin PaTox and LifA/Efa1-related large cytotoxin, and similar proteins. This subfamily includes the cysteine protease domain of Photorhabdus asymbiotica toxin PaTox, a large virulence-associated multifunctional protein toxin. This domain is similar to AvrPphB protease found in Pseudomonas syringae, a C58 protease. Mutation studies show that this domain enhances cytotoxic effects of the toxin, and therefore is essential for full PaTox activity. Also included in this family is the enteropathogenic Escherichia coli (EPEC) factor for adherence/lymphocyte activation inhibitor (efa1/lifA) gene which is strongly associated with diarrhea. Efa1/LifA proteins are important for A/E lesion formation efficiency in EPEC strains lacking multiple effectors. This domain contains the invariant C/H/D residues conserved in the C58/YopT family. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| AMG29389.2 | 0.0 | 110 | 2978 | 1 | 2874 |
| AVF62353.1 | 0.0 | 1 | 2974 | 1 | 2974 |
| AMG08231.1 | 0.0 | 1 | 2974 | 1 | 2970 |
| QTA27033.1 | 0.0 | 24 | 2974 | 27 | 2977 |
| AUJ89621.1 | 0.0 | 24 | 2974 | 27 | 2975 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6II2_A | 1.96e-90 | 672 | 1018 | 315 | 667 | Crystalstructure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II2_B Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II2_C Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II2_D Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O [Vibrio vulnificus] |
| 6II0_A | 8.07e-89 | 677 | 1018 | 5 | 352 | Crystalstructure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II0_B Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II0_C Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II0_D Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O [Vibrio vulnificus],6II6_A Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O in complex with a human ADP-ribosylation factor 3 (ARF3) [Vibrio vulnificus],6II6_B Crystal structure of the Makes Caterpillars Floppy (MCF)-Like effector of Vibrio vulnificus MO6-24/O in complex with a human ADP-ribosylation factor 3 (ARF3) [Vibrio vulnificus] |
| 5VQM_A | 1.67e-14 | 187 | 498 | 26 | 305 | ChainA, Toxin B [Clostridioides difficile R20291],5VQM_B Chain B, Toxin B [Clostridioides difficile R20291] |
| 7SO7_A | 8.32e-14 | 187 | 498 | 26 | 305 | ChainA, Toxin B [Clostridioides difficile],7SO7_B Chain B, Toxin B [Clostridioides difficile] |
| 7SO5_A | 8.40e-14 | 187 | 498 | 24 | 303 | ChainA, Toxin B [Clostridioides difficile R20291] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| A0A2S3R7M0 | 1.79e-84 | 672 | 1012 | 3215 | 3561 | Multifunctional-autoprocessing repeats-in-toxin OS=Vibrio vulnificus OX=672 GN=CRN52_02910 PE=1 SV=1 |
| Q46342 | 6.06e-13 | 187 | 494 | 26 | 301 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| P0DUB4 | 1.04e-12 | 187 | 494 | 26 | 301 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| P18177 | 1.04e-12 | 187 | 498 | 26 | 305 | Toxin B OS=Clostridioides difficile OX=1496 GN=tcdB PE=1 SV=3 |
| T0D3N5 | 1.04e-12 | 187 | 494 | 26 | 301 | Cytotoxin-L OS=Paeniclostridium sordellii (strain ATCC 9714 / DSM 2141 / JCM 3814 / LMG 15708 / NCIMB 10717 / 211) OX=1292036 GN=tcsL PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000064 | 0.000001 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |