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CAZyme Information: MGYG000002538_00333

You are here: Home > Sequence: MGYG000002538_00333

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Klebsiella pneumoniae
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Klebsiella; Klebsiella pneumoniae
CAZyme ID MGYG000002538_00333
CAZy Family GT2
CAZyme Description Acetyl-coenzyme A synthetase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
652 MGYG000002538_1|CGC5 71996.77 5.8282
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002538 5484149 Isolate United States North America
Gene Location Start: 358153;  End: 360111  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002538_00333.

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd05967 PrpE 0.0 24 638 1 614
Propionyl-CoA synthetase (PrpE). EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
COG0365 Acs 0.0 68 631 1 528
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism].
cd05968 AACS_like 0.0 24 635 9 610
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase. This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
PLN02654 PLN02654 0.0 20 643 28 662
acetate-CoA ligase
PRK10524 prpE 0.0 24 648 4 627
propionyl-CoA synthetase; Provisional

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CAE6201330.1 7.43e-247 20 642 578 1210
CAE6201338.1 1.02e-246 20 642 589 1221
AFZ04852.1 5.52e-26 67 615 571 1074
BAY90071.1 1.08e-23 81 622 579 1089
BAY30132.1 1.08e-23 81 615 580 1079

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2P2Q_A 0.0 1 652 1 652
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
2P2J_A 0.0 1 652 1 652
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2J_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
2P2M_A 0.0 1 652 1 652
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
2P2F_A 0.0 1 652 1 652
ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2F_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium]
5JRH_A 0.0 1 652 1 652
Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q7MBA6 0.0 1 650 1 650
Acetyl-coenzyme A synthetase OS=Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) OX=243265 GN=acs PE=3 SV=1
Q8D1G8 0.0 1 652 1 652
Acetyl-coenzyme A synthetase OS=Yersinia pestis OX=632 GN=acs PE=3 SV=2
Q87KU7 0.0 1 645 1 646
Acetyl-coenzyme A synthetase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) OX=223926 GN=acsA PE=3 SV=1
Q7MGU3 0.0 1 645 1 646
Acetyl-coenzyme A synthetase OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=acsA PE=3 SV=2
Q8DCZ9 0.0 1 645 1 646
Acetyl-coenzyme A synthetase OS=Vibrio vulnificus (strain CMCP6) OX=216895 GN=acsA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.999992 0.000040 0.000001 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002538_00333.