CAZyme Information: MGYG000002545_00283

Basic Information

• Species: Faecalibacterium prausnitzii_G
• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Faecalibacterium; Faecalibacterium prausnitzii_G
• CAZyme ID: MGYG000002545_00283
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 4

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
764	MGYG000002545_1|CGC2	84234.97	4.3594

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002545	2833887	Isolate	Ireland	Europe

• Gene Location: Start: 278744; End: 281038 Strand: -

Full Sequence      

MAGSLVAVGAVYYVVQATASDGDLLDLDNIELSQSSLVVATDPDTGAQVEYATLRSSNSH
RVWADLEQIPTNLQYAFICTEDKDFYSEPGVNFKRTIGAMINEYLLPIYSSKQGASTLEQ
QLIKNLTSDKSASGIEGALRKLREIYRALILSRSYSKETILEAYLNTISFTGTIQGVQTA
ANEYFDKDVSELTLWECASIASITKNPTNYNPYTNPENLINRRNFLLYNMWQQGVISEED
YRSAAAQPLVLAETDNTKKSSSTTSYFTDALFNEVVKDIMAKEGVDESTAQSMLYTGGYT
IEATVNPKIQTAMENLMLNTDDAYFPAGWHEEEVTSISDDDVQVYNEDGTPKTRTGDDGT
VYYYRNVRTQAAMVTLDYDGNVIAMVGGLGEKTKSLSLNRAYGVTRQTGSTIKPIGAYAL
GIEYGLVNWSTMLNNSPLYLKQDMVIRDEDYCRRNGLMGLTDKQLKAYPNAWRSWPRNYG
GNYGDGSDLPLWNGLARSLNTIAIRVGDLVGANNIFNFVYNTLQLSTLDPVNDVGLAQMV
MGSQTHGVTPMALAAAFQIFYDGEYTTPHLYTRVLDRDGNIYMESNDTSYQALTPQTAYV
MNRLLKNVLFSSVGTASGRYPNSNGMEAFGKTGTASDEKDLWFVGGTPYYVTAVWWGYDA
PYDMTKTLGKQQAKTRTCVTAWKALMEQVQADLPYKAFPAADGVVERSYCTQSGLLASGS
CPSTAVGYYRADDLPDVCNYSHGQAAVASEPLAPEPDTTNLDTD

Enzyme Prediction     

No EC number prediction in MGYG000002545_00283.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	57	230	1.7e-53	0.943502824858757

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.02e-131	17	760	37	660	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	3.74e-129	60	689	1	528	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	5.33e-108	50	763	61	788	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	4.91e-69	52	659	137	658	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	1.20e-59	60	230	12	176	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AXA81016.1	0.0	1	764	64	827
ATL89188.1	0.0	1	764	49	816
ATO98888.1	0.0	1	764	49	816
QIA44319.1	0.0	1	764	66	833
AXB28952.1	0.0	1	764	74	847

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7U4H_A	8.74e-51	60	729	39	801	ChainA, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX],7U4H_B Chain B, Penicillin-binding protein 1A (Pbp1a) [Chlamydia trachomatis D/UW-3/CX]
4OON_A	1.14e-44	69	757	47	786	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	2.11e-41	65	694	43	720	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	1.29e-39	53	658	20	557	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
3ZG8_B	2.72e-39	151	659	3	433	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q891X1	1.31e-73	57	743	76	715	Penicillin-binding protein 1A OS=Clostridium tetani (strain Massachusetts / E88) OX=212717 GN=pbpA PE=3 SV=1
Q97GR5	3.40e-73	57	758	89	718	Penicillin-binding protein 1A OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=pbpA PE=3 SV=1
A7GHV1	6.24e-73	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) OX=441772 GN=pbpA PE=3 SV=1
A7FY32	2.36e-72	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1
A5I6G4	2.36e-72	57	716	72	670	Penicillin-binding protein 1A OS=Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) OX=441771 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.990305	0.009691	0.000020	0.000013	0.000009	0.000015

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002545_00283.