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CAZyme Information: MGYG000002551_00234

You are here: Home > Sequence: MGYG000002551_00234

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Haemophilus_A paraphrohaemolyticus
Lineage Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Pasteurellaceae; Haemophilus_A; Haemophilus_A paraphrohaemolyticus
CAZyme ID MGYG000002551_00234
CAZy Family GH23
CAZyme Description Membrane-bound lytic murein transglycosylase F
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
483 MGYG000002551_7|CGC1 55466.15 5.1728
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002551 1748237 MAG China Asia
Gene Location Start: 1547;  End: 2998  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002551_00234.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH23 293 447 4.4e-23 0.8518518518518519

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
PRK10859 PRK10859 0.0 1 470 1 471
membrane-bound lytic murein transglycosylase MltF.
COG4623 MltF 0.0 21 479 1 463
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
cd13403 MLTF-like 1.10e-72 300 451 10 161
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
cd01009 PBP2_YfhD_N 1.01e-65 43 264 1 222
The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
smart00062 PBPb 4.74e-27 44 264 1 219
Bacterial periplasmic substrate-binding proteins. bacterial proteins, eukaryotic ones are in PBPe

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QEN10654.1 0.0 1 483 1 483
QRP11846.1 0.0 1 483 1 483
AWI50828.1 1.49e-277 1 476 1 472
AIJ32454.1 3.04e-266 1 461 1 461
AFU20322.1 3.04e-266 1 461 1 461

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4OZ9_A 1.67e-94 38 449 6 421
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with isoleucine [Pseudomonas aeruginosa PAO1]
4OWD_A 2.06e-94 38 449 13 428
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with cysteine [Pseudomonas aeruginosa PAO1],4OXV_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with valine [Pseudomonas aeruginosa PADK2_CF510],4P0G_A Crystal structure of MltF from Pseudomonas aeruginosa complexed with bulgecin and muropeptide [Pseudomonas aeruginosa PAO1],4P11_A Native crystal structure of MltF Pseudomonas aeruginosa [Pseudomonas aeruginosa PAO1]
4OYV_A 5.79e-94 38 449 13 428
Crystalstructure of MltF from Pseudomonas aeruginosa complexed with leucine [Pseudomonas aeruginosa PAO1]
5AA4_A 1.85e-93 45 449 6 414
Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_C Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]
5AA4_B 1.85e-93 45 449 6 414
Crystalstructure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013],5AA4_D Crystal structure of MltF from Pseudomonas aeruginosa in complex with cell-wall tetrapeptide [Pseudomonas aeruginosa BWHPSA013]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
B3GYE5 6.63e-262 1 461 1 461
Membrane-bound lytic murein transglycosylase F OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76) OX=537457 GN=mltF PE=3 SV=1
A3N214 2.69e-261 1 461 1 461
Membrane-bound lytic murein transglycosylase F OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) OX=416269 GN=mltF PE=3 SV=2
B0BQV5 2.69e-261 1 461 1 461
Membrane-bound lytic murein transglycosylase F OS=Actinobacillus pleuropneumoniae serotype 3 (strain JL03) OX=434271 GN=mltF PE=3 SV=2
Q7VN03 1.26e-254 1 462 1 462
Membrane-bound lytic murein transglycosylase F OS=Haemophilus ducreyi (strain 35000HP / ATCC 700724) OX=233412 GN=mltF PE=3 SV=1
Q65RJ5 8.35e-211 1 457 1 457
Membrane-bound lytic murein transglycosylase F OS=Mannheimia succiniciproducens (strain MBEL55E) OX=221988 GN=mltF PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.977777 0.008166 0.013397 0.000025 0.000018 0.000637

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002551_00234.