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CAZyme Information: MGYG000002561_00425

You are here: Home > Sequence: MGYG000002561_00425

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species Bacteroides sp902388495
Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides sp902388495
CAZyme ID MGYG000002561_00425
CAZy Family GH99
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
418 MGYG000002561_2|CGC8 46660.25 4.9885
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002561 4554549 MAG China Asia
Gene Location Start: 253502;  End: 254758  Strand: +

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002561_00425.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH99 55 377 3.5e-66 0.9880239520958084

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd11575 GH99_GH71_like_3 4.58e-140 47 408 1 376
Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.
cd11573 GH99_GH71_like 5.29e-26 107 375 5 282
Glycoside hydrolase families 71, 99, and related domains. This superfamily of glycoside hydrolases contains families GH71 and GH99 (following the CAZY nomenclature), as well as other members with undefined function and specificity.
cd11574 GH99 6.39e-25 57 353 1 319
Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase. This family of glycoside hydrolases 99 (following the CAZY nomenclature) includes endo-alpha-1,2-mannosidase (EC 3.2.1.130), which is an important membrane-associated eukaryotic enzyme involved in the maturation of N-linked glycans. Specifically, it cleaves mannoside linkages internal to N-linked glycan chains by hydrolyzing an alpha-1,2-mannosidic bond between a glucose-substituted mannose and the remainder of the chain. The biological function and significance of the soluble bacterial orthologs, which may have obtained the genes via horizontal transfer, is not clear.
pfam16317 Glyco_hydro_99 2.58e-15 55 345 6 308
Glycosyl hydrolase family 99. This domain, around 350 residues, is mainly found in some uncharacterized proteins from bacteroides to human. Some proteins in this family, annotated as endo-alpha-mannosidases cleave mannoside linkages internally within an N-linked glycan chain, short circuiting the classical N-glycan biosynthetic pathway. This domain reveals a (beta-alpha)(8) barrel fold in which the catalytic centre is present in a long substrate-binding groove, consistent with cleavage within the N-glycan chain, providing a foundation upon which to develop new enzyme inhibitors targeting the hijacking of N-glycan synthesis in viral disease and cancer.
cd11578 GH99_GH71_like_1 2.60e-07 57 359 3 308
Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
CCO21487.1 8.35e-148 43 415 39 407
CCO21838.1 8.35e-148 43 415 39 407
CCO21727.1 8.35e-148 43 415 39 407
CCO21747.1 8.35e-148 43 415 39 407
CCO21767.1 8.35e-148 43 415 39 407

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4ACZ_A 2.19e-14 42 345 31 339
Structureof the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],4AD0_A Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_B Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_C Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482],4AD0_D Structure of the GH99 endo-alpha-mannosidase from Bacteriodes thetaiotaomicron in complex with BIS-TRIS-Propane [Bacteroides thetaiotaomicron VPI-5482]
4ACY_A 2.93e-14 42 345 31 339
Selenomethioninederivative of the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],4ACY_B Selenomethionine derivative of the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
4ACZ_B 3.92e-14 42 345 31 339
Structureof the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482]
4AD1_A 5.43e-10 56 356 42 354
Structureof the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens [Bacteroides xylanisolvens XB1A],4AD2_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD2_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine [Bacteroides xylanisolvens XB1A],4AD3_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_B Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_C Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD3_D Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with Glucose-1,3-deoxymannojirimycin [Bacteroides xylanisolvens XB1A],4AD4_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-isofagomine and alpha-1,2- mannobiose [Bacteroides xylanisolvens XB1A],4AD5_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with glucose-1,3-deoxymannojirimycin and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],4UTF_A Structure of the GH99 endo-alpha-mannosidase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine and alpha- 1,2-mannobiose [Bacteroides xylanisolvens XB1A],4V27_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-isofagomine [Bacteroides xylanisolvens XB1A]
5LYR_A 5.53e-10 56 356 47 359
Structureof the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-noeuromycin [Bacteroides xylanisolvens XB1A],5M03_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-noeuromycin and 1,2-alpha-mannobiose [Bacteroides xylanisolvens XB1A],5M17_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-1,2-dideoxymannose [Bacteroides xylanisolvens XB1A],5M3W_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-1,2-dideoxymannose and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],5M5D_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-D-glucal [Bacteroides xylanisolvens XB1A],5MC8_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-D-glucal and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6FAM_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-2-aminodeoxymannojirimycin [Bacteroides xylanisolvens XB1A],6FAR_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with mannose-alpha-1,3-mannoimidazole [Bacteroides xylanisolvens XB1A],6FWI_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-mannosamine) [Bacteroides xylanisolvens XB1A],6FWJ_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-mannosamine) and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6FWM_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-1,2-anhydro-mannose hydrolyzed by enzyme [Bacteroides xylanisolvens XB1A],6FWP_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-1,3-mannobiose and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6HMG_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-glucosamine) [Bacteroides xylanisolvens XB1A],6HMH_A Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-glucosamine) and alpha-1,2-mannobiose [Bacteroides xylanisolvens XB1A],6ZJ6_AAA Chain AAA, Glycosyl hydrolase family 71 [Bacteroides xylanisolvens XB1A]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q1L8D2 3.65e-10 55 345 90 401
Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Danio rerio OX=7955 GN=maneal PE=3 SV=1
Q6NXH2 1.54e-08 38 345 84 414
Glycoprotein endo-alpha-1,2-mannosidase OS=Mus musculus OX=10090 GN=Manea PE=2 SV=1
Q6P1J0 8.25e-08 58 345 116 411
Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Mus musculus OX=10090 GN=Maneal PE=2 SV=1
Q5VSG8 2.58e-07 58 345 121 416
Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=2 SV=1
Q5RD93 4.57e-07 39 345 85 414
Glycoprotein endo-alpha-1,2-mannosidase OS=Pongo abelii OX=9601 GN=MANEA PE=2 SV=1

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000027 0.015220 0.984771 0.000007 0.000010 0.000007

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002561_00425.