CAZyme Information: MGYG000002575_00409

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae
• CAZyme ID: MGYG000002575_00409
• CAZy Family: GH2
• CAZyme Description: hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
2062		231940.42	5.136

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002575	2444047	MAG	China	Asia

• Gene Location: Start: 3394; End: 9582 Strand: +

Full Sequence      

MKKSNYRKWWLLPLGMVVCLAGMAQNRLPRANSEARENVISLSGEWQFQRDDQRAGKQEK
WYNRTSFNDKIMLPSTIDEQHKGSAEAKQDGRFTRLYAYEGPAWYQRTVDIPAMMEGCSL
FLCLERTKVTDVWFDGQYVGSDSSLITTQKFLLTEQAVPGVHRITVRVTNGADENPPVSG
CHQMSNGTQTNWNGILGRMEIHAVRDVWLEQVQAYPNLADRNVRLRFHIKKKGQKMEGRM
QLELQSWNTKKPHVFETLMLPVVMESNDTVFEYVYPLGDKMQTWDEFSPTLYRVKSTLTT
TINGMNVSSVRETDFGMREITSDSQGFVINGRPAFMRGKHDAAVFPHTGYPPMDVDEWIR
ILKIYKDYGLNHVRCHTWCPPLAAFEAADIVGIYWLPELPHWGAVGGKVDIIQGDVEQKT
EIYDNTTSYLVSEGFRMLDEMGSQPSFTMFELGNEMSGSREEMSKIISKFRDHDPRHLYA
GGANNFLWAPQFTQGDDFWTTTMTGGTYGAGVYHDTKGLEVRSSYPNHNEGHVNNILCGT
DYDYSSAITRFDKPIVSHETGQYQVYPNYNQIEKFTGVTRAYNLDTYRQRLEEAGMGDRA
EDFFRASGQLAALCYREDIESAIRTDRFGGFQLLDLQDYPGQGTALVGMLDSYLDSKGII
TPEQWREFCCEVVPLLRHKSFTYTTDETFKSRAVIANFGAADLSLKPEWTVSYADGAQIA
HGSLAQTTMPCGARTDVGSIEFDLSEVKAPCKLTVTLSLPGTSYHNSYSIWVYPRKVDTS
VPQGIKVFYSLNSEAQAELERGGKVLILPMSAAIPTSIDGAFQSDFWCYSMFRGYDPPGT
LGICLNPQHAAFDQFPTEYHSNWQWWRMLKNGRPINLNTLPQTFRPIVEVIDNVTLNRRL
GVMFEAKVGCGQLLVCSMDLQNLQAYPEARQIYASLLGYMASDKFAPTQELTIEQLGTVL
TSGVPTETKVTRSIRIDDMNFSVSPAADYKLSGRTVTFDHSNNLFCTVTDGSKGYIKLND
KYARLLIPVMKCASKGSFVSSNTTLHYIDTIGHYRMHVIGDVKFNQTDSTQWIIQLDALD
GGVQGIVGLSNTNWGSVLTLTLGDVCLQQTVVAPYIGDVEKSRVPIANMQEPYTGGLFGP
SWESLSQYQVPEWFRNAKFGIWAHWGPQCVPEQGDWYARHMYEPGHRHYQYHVEHYGHPS
QFGFKDIIHTWKAENWEPNMLMNLYKRVGARYFMAMANHHDNFDLWDSRYHKWNSVDIGP
EKNIINVWQKAARAEGLPFGVSVHSSHAWVWYGTARGADTEGGMAGVPYDGNLAVSDGVG
TWWEGLDPQELYVQNHEPNPWMSWDWNAGDPSVEYCEDFYNRTVDLINKYQPDIVYFDDT
ALPLWPASDAGLYVTANYYNSSMQWTGRAPQCVVTGKKLSGIQRRGIVEDIEKGAIDTIS
AIPWQTCSCLGEYHYRRSYYEDDSYKSAETVVRMLCDIVSKNGNLLLSVPMRGDGTIDDK
EESILEGVARWMEVNSECIYDTRPWVVFGEGPDAETPREGRETGTYGADDFRFTVKDDSL
YVIVMNRPADGRVRIKSLGTVNGKCDRKFHSLAVLGGGVPEYSREHNALLISLPASDSPI
QVVKIVLSKEQLEVKEPFVLRRQNSVEDMVPTSKTFGESYKMTSTSVTFDHSNALISQNT
TTNNGYLPVPEGSQKLVLHIDKVSSQGAYNTDNTTLYYVNASGELSSHNYGKIELPSEGN
FDFVLPLTPDVLVDGCQGLLSISNSNWSSVLTLDVSEAYFQRGNEVAYCAWGDPTNEDTY
ERITNLLSRSDLNVLDLSGIEGLDASTDWHALANNPNILIFTNDNKAEQTNEVSKGRCTE
LYLESGSPSGFYAPCSFTAEHVQVNVPVAEDGQVLILPFDITPSDDVHLYCLTAVTGDSV
YCERVWGMAEANSPLVYYSDTEVVLSGSGIVQSSDSDVSSEFFHGTYTPVMVIAGGYKWG
TDENGHAGFHLLRTEANLLPFSYILKYEGGPFIPLHLPDVTTHIEDVKNTTHGPAFYDLS
GRRVYDNSRGIRVSKGRKYLIK

Enzyme Prediction     

No EC number prediction in MGYG000002575_00409.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH29	1127	1521	6.3e-94	0.9508670520231214
GH2	31	655	3.1e-58	0.5904255319148937

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
smart00812	Alpha_L_fucos	2.21e-115	1138	1578	7	384	Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis.
pfam01120	Alpha_L_fucos	1.09e-107	1130	1517	3	333	Alpha-L-fucosidase.
COG3669	AfuC	4.21e-94	1164	1596	1	396	Alpha-L-fucosidase [Carbohydrate transport and metabolism].
COG3250	LacZ	1.53e-20	28	486	1	439	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
PRK10150	PRK10150	1.23e-09	32	343	6	303	beta-D-glucuronidase; Provisional

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ALJ47140.1	0.0	14	960	15	959
SCV06550.1	0.0	14	960	15	959
QRQ58638.1	0.0	14	960	15	959
QUT25625.1	0.0	14	960	15	959
BBE17052.1	5.46e-247	31	967	21	948

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
7LJJ_A	6.57e-77	1144	1614	49	495	ChainA, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135],7LK7_A Chain A, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135]
7LNP_A	2.99e-76	1144	1614	49	495	ChainA, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135],7LNP_C Chain C, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135],7LNP_D Chain D, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135],7LNP_E Chain E, Exo-alpha-L-galactosidase [Phocaeicola plebeius DSM 17135]
4NI3_A	7.17e-50	1136	1625	5	489	ChainA, Alpha-fucosidase GH29 [Fusarium graminearum],4NI3_B Chain B, Alpha-fucosidase GH29 [Fusarium graminearum],4PSP_A Chain A, Alpha-fucosidase GH29 [Fusarium graminearum],4PSP_B Chain B, Alpha-fucosidase GH29 [Fusarium graminearum],4PSR_A Chain A, Alpha-fucosidase GH29 [Fusarium graminearum],4PSR_B Chain B, Alpha-fucosidase GH29 [Fusarium graminearum]
1ODU_A	1.81e-40	1138	1583	8	406	CrystalStructure Of Thermotoga Maritima Alpha-Fucosidase In Complex With Fucose [Thermotoga maritima MSB8],1ODU_B Crystal Structure Of Thermotoga Maritima Alpha-Fucosidase In Complex With Fucose [Thermotoga maritima MSB8]
2ZWY_A	2.04e-40	1138	1583	8	406	alpha-L-fucosidase[Thermotoga maritima],2ZWY_B alpha-L-fucosidase [Thermotoga maritima],2ZWZ_A alpha-L-fucosidase complexed with inhibitor, Core1 [Thermotoga maritima],2ZWZ_B alpha-L-fucosidase complexed with inhibitor, Core1 [Thermotoga maritima],2ZX5_A alpha-L-fucosidase complexed with inhibitor, F10 [Thermotoga maritima],2ZX5_B alpha-L-fucosidase complexed with inhibitor, F10 [Thermotoga maritima],2ZX6_A alpha-L-fucosidase complexed with inhibitor, F10-1C [Thermotoga maritima],2ZX6_B alpha-L-fucosidase complexed with inhibitor, F10-1C [Thermotoga maritima],2ZX7_A alpha-L-fucosidase complexed with inhibitor, F10-2C [Thermotoga maritima],2ZX7_B alpha-L-fucosidase complexed with inhibitor, F10-2C [Thermotoga maritima],2ZX8_A alpha-L-fucosidase complexed with inhibitor, F10-2C-O [Thermotoga maritima],2ZX8_B alpha-L-fucosidase complexed with inhibitor, F10-2C-O [Thermotoga maritima],2ZX9_A alpha-L-fucosidase complexed with inhibitor, B4 [Thermotoga maritima],2ZX9_B alpha-L-fucosidase complexed with inhibitor, B4 [Thermotoga maritima],2ZXA_A alpha-L-fucosidase complexed with inhibitor, FNJ-acetyl [Thermotoga maritima],2ZXA_B alpha-L-fucosidase complexed with inhibitor, FNJ-acetyl [Thermotoga maritima],2ZXB_A alpha-L-fucosidase complexed with inhibitor, ph-6FNJ [Thermotoga maritima],2ZXB_B alpha-L-fucosidase complexed with inhibitor, ph-6FNJ [Thermotoga maritima],2ZXD_A alpha-L-fucosidase complexed with inhibitor, iso-6FNJ [Thermotoga maritima],2ZXD_B alpha-L-fucosidase complexed with inhibitor, iso-6FNJ [Thermotoga maritima]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
C3YWU0	1.98e-31	1138	1575	18	393	Alpha-L-fucosidase OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_56888 PE=3 SV=2
Q9BTY2	2.79e-30	1138	1614	34	446	Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2
Q5RFI5	6.56e-30	1138	1614	32	444	Plasma alpha-L-fucosidase OS=Pongo abelii OX=9601 GN=FUCA2 PE=2 SV=1
P48300	1.18e-29	1138	1614	37	444	Tissue alpha-L-fucosidase OS=Canis lupus familiaris OX=9615 GN=FUCA1 PE=2 SV=1
P17164	2.04e-29	1135	1577	26	408	Tissue alpha-L-fucosidase OS=Rattus norvegicus OX=10116 GN=Fuca1 PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.104221	0.260006	0.633669	0.000680	0.000543	0.000867

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002575_00409.