CAZyme Information: MGYG000002585_00231

Basic Information

• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides
• CAZyme ID: MGYG000002585_00231
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
379	MGYG000002585_2|CGC3	43052.95	6.8835

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002585	2701793	MAG	China	Asia

• Gene Location: Start: 113035; End: 114174 Strand: -

Full Sequence      

MKYYLIVGEASGDLHASHLMAALKEEDPHAEFRFFGGDMMAAVGGTMVKHYKELAYMGFI
PVLLHLRTIFANMKRCKEDIVAWQPDVLILVDYPGFNLSIAKFIHAHTSIPVYYYISPKI
WAWKEYRIKNIKRDVDELFSILPFEVEFFEGKHQYPIHYVGNPTMDEVTAFQTSCSETFD
DFVQANGLPSRPIIALLAGSRKQEIKDNLPDMLRAAAAFPNYQLVLAGAPGISPEYYERY
VGDADVKIIFGKTFPLLRQADAALVTSGTATLETALFRVPQAVCYHTPIGKVIAFLRRHI
LTVKYISLVNLIANREVVKELVADTMTVEQIRSELERILYNKEYRQRMLDGYEYMASRLG
EAGAPKRAAQEMVALLKDF

Enzyme Prediction     

No EC number prediction in MGYG000002585_00231.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	359	4.1e-113	0.9887005649717514

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	1.73e-109	1	377	2	376	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	1.57e-96	1	377	2	380	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	2.51e-73	4	371	2	373	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	1.12e-65	5	375	10	385	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	2.00e-48	1	372	2	344	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QPH59250.1	7.60e-252	1	377	1	377
QMI80442.1	3.09e-251	1	377	1	377
QBJ18940.1	1.26e-250	1	377	1	377
QUT60955.1	2.54e-250	1	377	1	377
QQA29481.1	2.54e-250	1	377	1	377

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8S_A	6.96e-38	5	375	11	380	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]
5W8N_A	1.87e-37	5	375	11	380	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	3.93e-69	2	376	6	378	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q6ALW0	2.46e-64	5	376	14	386	Lipid-A-disaccharide synthase OS=Desulfotalea psychrophila (strain LSv54 / DSM 12343) OX=177439 GN=lpxB PE=3 SV=1
B3E4H8	5.38e-62	2	378	8	382	Lipid-A-disaccharide synthase OS=Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) OX=398767 GN=lpxB PE=3 SV=1
Q3A550	4.07e-60	2	379	9	385	Lipid-A-disaccharide synthase OS=Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1) OX=338963 GN=lpxB PE=3 SV=1
Q39T49	4.66e-60	2	376	8	380	Lipid-A-disaccharide synthase OS=Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) OX=269799 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000071	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002585_00231.