CAZyme Information: MGYG000002590_00300

Basic Information

• Species: CAG-594 sp900766325
• Lineage: Bacteria; Firmicutes; Bacilli; RF39; UBA660; CAG-594; CAG-594 sp900766325
• CAZyme ID: MGYG000002590_00300
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
939		104923.83	5.1215

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002590	1062927	MAG	China	Asia

• Gene Location: Start: 10398; End: 13217 Strand: +

Full Sequence      

MMKKRNKKSNNISKNIKAKANEVKNKVVKKSSKTKTKAQMSKRKRIILNVLLVMVIAFVA
IIVTFFSYVIIKAPKFDPNNLKFTQMSEIYDSDGNLIVKMGNENRTEITYDDLPEVLIDA
IIATEDARFFQHNGFDLARFVKAGFGQVLGQDSGGASTLTMQIVKNNYTSTVSTGFEGVV
RKFTDIYLSIFKVERKYTKKEILEFYVNDSYLGNGAYGVEQASLNYFGKSVSELNLAEAS
FIAGLFQSPTYYNPYNYPERAEERRQTVLYLMQRHGYITEEERQIAEATPITSLIKTEQT
NNTYSEYQGYIDTVVEELEEEYGLNPYTTPLKIYTTMNREKQDFVNKVMNGEAWTWENDL
VQAGIVMTESETGEVIAVGAGRNKSTERSYNYATMTNKHIGSTAKPIFDYGPAVEYLGWG
TVNYIKDEPWTYTNGPSMSNSDGGYRGVLPMYQALGLSRNVTALKTFQQVSSEAGNDKIK
EFVTNLGITPEVCNPGYDYDKDNDICVNPDDKSDTHQPNKIHEAHSIGSFTGGDGDDESR
TSPMTMAGAYQAFSNGGYYIKPHTITKFVYKETDEVVEAKYDKTKVMEDSTAYIINYALS
WSVTDGLARSAANIGGVQVAAKTGTSNFSDEDIKRYGLSRSAINDLWVCGYTPTYTLTFW
YGYDRVYKEHYSTTADWTTRDRFYRNLAENLFDKDGSTFEVPSSIEAVEVVKNSIPLKLA
SASTPDSMKVTGYFRKGTAPTETTAEYDTLPSVSGVTSSVSGNTVHLSWNGLSAEDMLSL
NSDESFGILGYDIYVKNGSSGSETYVGTTTSDSYTHTTNYSNPVYVIYTAYANYKTNRSK
GVEHSVSIKADFDVRASNETINQGERFIDSRPIVVLYNSVDVTQESTIELIDGEVNTDTP
GNYTLTYRVTYQGSSTTIKRTITVREKTTSSTTTSSTTQ

Enzyme Prediction     

No EC number prediction in MGYG000002590_00300.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	93	273	8e-57	0.9943502824858758

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02074	PBP_1a_fam	2.38e-156	104	664	1	502	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	1.96e-147	38	665	7	573	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
COG5009	MrcA	8.12e-105	40	748	1	772	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
TIGR02071	PBP_1b	1.09e-73	103	664	145	658	penicillin-binding protein 1B. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of a particular bifunctional transglycosylase/transpeptidase in E. coli and other Proteobacteria, designated penicillin-binding protein 1B. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
pfam00912	Transgly	1.26e-70	93	273	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
QED48401.1	8.44e-149	66	769	53	714
QOK24849.1	5.67e-148	66	775	52	720
AND41200.1	1.28e-147	66	769	52	714
AXM90108.1	7.27e-146	41	742	26	685
ACJ33515.1	2.01e-145	41	742	26	685

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3DWK_A	8.74e-91	87	705	8	602	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
2OLU_A	6.76e-88	72	705	2	611	StructuralInsight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Apoenzyme [Staphylococcus aureus],2OLV_A Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus],2OLV_B Structural Insight Into the Transglycosylation Step Of Bacterial Cell Wall Biosynthesis : Donor Ligand Complex [Staphylococcus aureus]
3ZG8_B	5.35e-61	192	675	2	444	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	1.83e-57	192	675	2	444	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
3UDF_A	3.49e-45	88	665	22	690	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P39793	8.48e-125	44	748	35	699	Penicillin-binding protein 1A/1B OS=Bacillus subtilis (strain 168) OX=224308 GN=ponA PE=1 SV=1
Q04707	1.24e-96	66	686	32	643	Penicillin-binding protein 1A OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=ponA PE=1 SV=2
Q8DR59	2.40e-95	66	686	32	643	Penicillin-binding protein 1A OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbpA PE=1 SV=1
Q00573	1.72e-92	66	663	32	600	Penicillin-binding protein 1A (Fragment) OS=Streptococcus oralis OX=1303 GN=ponA PE=3 SV=1
P38050	7.51e-66	42	734	5	637	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.999906	0.000097	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

start	end
46	68