CAZyme Information: MGYG000002610_01954

Basic Information

• Lineage: Bacteria; Firmicutes_A; Clostridia; Oscillospirales; Ruminococcaceae; Faecalibacterium
• CAZyme ID: MGYG000002610_01954
• CAZy Family: GH2
• CAZyme Description: Beta-glucuronidase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
598	MGYG000002610_28|CGC1	67648.92	5.3298

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002610	2250349	MAG	China	Asia

• Gene Location: Start: 6309; End: 8105 Strand: -

Full Sequence      

MLYPEQNEARLKLSLDGTWAFALGSCAENQFDPAKPLPDAQPIAVPASYNDQNDQTTALR
RHYGWAWYQRKVTLPTFCAGQRVVLRFGSVTHTAKVWLNGQLIAQHKGGFTPFEADVTAL
LRPGETALLTVACDNRINHSTLPVGNEDGQLAFFGSDNAGIPSVEAAKRTATPQNRPNFD
FFNYAGIHRPVWLYTTQKEYIEDVTVVPAVDGTVQYAVKTTGSAPVHVTVLDADGNAVAS
AEGAEGTITIPEVHLWEPRPGTPYLYTLHITCGADVYDQTFGVRSIEVRGTQVLLNDKPL
YFKGFCKHEDFTAHGRGFDPVLNVKDVNLIHWANANTVRTSHYPYAEEFYDLCDREGILV
MDETPAVGIGGGAAVNPYKEYPLAEHHRQVLAEMIHRDKNHPCVVLWSLGNEPDLEHFPQ
DAYDYWHPLYELAHQLDPQNRPVTLVCCQNDYTKDITTRTMDIVCINRYYGWYNLSGDMD
AACYGLNQELDFWAEQHKPVMMSEYGADTVAGLHTAGAEMFSEEFQVEFYRRLDAEFDKR
PWFVGEFVWNFADYDTVQGPMRVDGNKKGLFTRDRRPKLGMHFLRQRWHDIPTFGFKE

Enzyme Prediction     

EC	3.2.1.31

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GH2	5	588	4.3e-119	0.6170212765957447

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK10150	PRK10150	0.0	1	598	1	602	beta-D-glucuronidase; Provisional
COG3250	LacZ	8.20e-108	1	588	1	595	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].
pfam02836	Glyco_hydro_2_C	2.15e-79	286	588	1	297	Glycosyl hydrolases family 2, TIM barrel domain. This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.
PRK10340	ebgA	1.17e-38	68	414	113	451	cryptic beta-D-galactosidase subunit alpha; Reviewed
PRK09525	lacZ	6.59e-29	12	443	52	485	beta-galactosidase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
CBL02671.1	0.0	1	598	1	598
CBL00249.1	0.0	1	598	1	598
AXB29257.1	0.0	1	598	1	598
AEN95939.1	1.38e-301	1	597	6	605
CUO31707.1	2.31e-301	1	597	1	600

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
6U7I_A	0.0	1	597	1	597	Faecalibacteriumprausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_B Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_C Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii],6U7I_D Faecalibacterium prausnitzii Beta-glucuronidase [Faecalibacterium prausnitzii]
6LD0_A	1.05e-238	1	597	3	669	ChainA, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD0_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LD6_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDB_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDC_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_A Chain A, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_B Chain B, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_C Chain C, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1],6LDD_D Chain D, LacZ1 Beta-galactosidase [Bifidobacterium dentium Bd1]
5Z1B_A	1.82e-237	1	597	25	691	Structureof Bifidobacterium dentium beta-glucuronidase complexed with coumarin-3-O-glucuronide [Bifidobacterium dentium ATCC 27679],5Z1B_B Structure of Bifidobacterium dentium beta-glucuronidase complexed with coumarin-3-O-glucuronide [Bifidobacterium dentium ATCC 27679],5Z1B_C Structure of Bifidobacterium dentium beta-glucuronidase complexed with coumarin-3-O-glucuronide [Bifidobacterium dentium ATCC 27679],5Z1B_D Structure of Bifidobacterium dentium beta-glucuronidase complexed with coumarin-3-O-glucuronide [Bifidobacterium dentium ATCC 27679]
6BO6_A	7.28e-194	1	597	1	609	Eubacteriumeligens beta-glucuronidase bound to UNC4917 glucuronic acid conjugate [[Eubacterium] eligens ATCC 27750]
6BJQ_A	1.57e-193	1	597	25	633	ChainA, Glycoside Hydrolase Family 2 candidate b-glucuronidase [[Eubacterium] eligens ATCC 27750]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P05804	6.12e-158	1	597	1	596	Beta-glucuronidase OS=Escherichia coli (strain K12) OX=83333 GN=uidA PE=1 SV=2
O18835	2.25e-144	1	588	27	625	Beta-glucuronidase OS=Canis lupus familiaris OX=9615 GN=GUSB PE=1 SV=1
O97524	1.26e-143	1	588	27	625	Beta-glucuronidase OS=Felis catus OX=9685 GN=GUSB PE=1 SV=1
Q4FAT7	1.84e-143	1	588	28	626	Beta-glucuronidase OS=Sus scrofa OX=9823 GN=GUSB PE=3 SV=1
P06760	8.94e-137	1	591	27	625	Beta-glucuronidase OS=Rattus norvegicus OX=10116 GN=Gusb PE=1 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000004	0.000011	0.000002	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002610_01954.