CAZyme Information: MGYG000002660_00990

Basic Information

• Species: UBA1174 sp900556855
• Lineage: Bacteria; Elusimicrobiota; Elusimicrobia; Elusimicrobiales; Elusimicrobiaceae; UBA1174; UBA1174 sp900556855
• CAZyme ID: MGYG000002660_00990
• CAZy Family: GT51
• CAZyme Description: Monofunctional biosynthetic peptidoglycan transglycosylase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
717		78246.09	7.6251

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002660	1485202	MAG	United Republic of Tanzania	Africa

• Gene Location: Start: 3748; End: 5901 Strand: -

Full Sequence      

MRFKAVILLFLIFCSAPRSYAEARPFYGPDNSVSVTDRNFLPLRNILSGKDGVMLPASLE
EVSPWLILSVLAAEDKRFFEHGGIDLKALARALWQNINAGKVVSGASTITQQLANAINPK
ERTFKGKLKEAYAAAALERELSKEEILEAYFNTVNFGGNIYGVQAAALVYFDTDASSLSL
SQAAFLAGLIKSPTQYNPLKNLKAGVKRRDEVLRRMLENGFINKELYALALEEDIKISPQ
NKKFTAPHYGLFVAGKAPAGAALIQSTIDGKIQSYIEEILPGYVEALKKNNVTNAAAAVL
DNKTGEVLALAGSADYFDERSSGQVNGALSLRQPGSALKPFVYGTAFEEGFLPSDKVEDQ
DKFFKGSFRPKNYDEEYHGAPSMRRALACSYNIPAVQVAGELGAYKVLETLKKAGFSSLE
KNADFYGLGLALGNGEVTLLELANAYRALANGGVWRPMVYALNPQVKQAGRAQRFFSEET
AFMLTDILSDNNARAAAFGLNSPLNMPFDFASKTGTSKDYKDNWAVGYSRRFTVAVWVGN
FDASPMRRISGITGAAPILRDIAVFLDGNYSSEKFETDSSFDMPASLAHADICPVSGKLA
SKNCAGSVREVFPADKLPKEHCALSLKEHQEDAGAVLGAAEGIIFPADGDIFVSSPSLAA
EAQQIKFKASEEGFWFIDGQKLPCPRSRECFWPIKSGKHRLKFEGRKTYQVSFEVLN

Enzyme Prediction     

No EC number prediction in MGYG000002660_00990.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	57	216	4.7e-59	0.903954802259887

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	0.0	32	715	11	726	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	4.87e-173	5	717	14	733	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
COG0744	MrcB	3.15e-150	5	562	29	592	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	2.20e-149	56	562	4	524	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	6.66e-111	55	624	68	770	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ACC98391.1	8.76e-237	27	717	38	719
AFE09736.1	1.23e-155	31	702	43	749
QAT85144.1	1.11e-153	31	702	44	750
AKU90474.1	8.37e-152	32	706	43	773
AFZ19661.1	7.59e-150	6	715	27	791

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4OON_A	1.72e-56	56	618	41	768	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]
3UDF_A	1.29e-50	55	558	40	707	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3DWK_A	2.31e-48	58	607	31	614	ChainA, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_B Chain B, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_C Chain C, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL],3DWK_D Chain D, Penicillin-binding protein 2 [Staphylococcus aureus subsp. aureus COL]
5FGZ_A	2.57e-46	66	558	168	685	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	3.04e-46	66	558	189	706	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	1.45e-76	51	562	60	560	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
O66874	5.42e-63	58	638	67	724	Penicillin-binding protein 1A OS=Aquifex aeolicus (strain VF5) OX=224324 GN=mrcA PE=1 SV=1
P38050	6.18e-63	56	539	69	569	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
P70997	1.85e-60	41	622	51	657	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
P40750	3.59e-58	71	539	93	596	Penicillin-binding protein 4 OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpD PE=1 SV=2

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.001006	0.807012	0.190796	0.000490	0.000364	0.000307

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002660_00990.