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CAZyme Information: MGYG000002717_00851

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Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Lineage Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides;
CAZyme ID MGYG000002717_00851
CAZy Family GH18
CAZyme Description hypothetical protein
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
572 MGYG000002717_47|CGC1 64426.22 6.1651
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002717 5602088 MAG Canada North America
Gene Location Start: 2234;  End: 3952  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002717_00851.

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH18 30 328 2e-73 0.9594594594594594

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
cd06548 GH18_chitinase 9.79e-106 32 321 1 322
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
smart00636 Glyco_18 1.18e-80 31 321 1 334
Glyco_18 domain.
pfam00704 Glyco_hydro_18 3.14e-79 31 321 1 307
Glycosyl hydrolases family 18.
cd02872 GH18_chitolectin_chitotriosidase 1.64e-68 32 316 1 336
This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.
pfam06283 ThuA 6.49e-63 348 569 2 213
Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
QDO71383.1 0.0 1 572 4 576
QQA31016.1 0.0 2 572 5 574
QUT64703.1 0.0 2 572 5 574
QUU00240.1 0.0 2 572 5 574
BBK89352.1 0.0 2 572 5 574

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
6INX_A 4.04e-53 49 335 27 342
Structuralinsights into a novel glycoside hydrolase family 18 N-acetylglucosaminidase from Paenibacillus barengoltzii [Paenibacillus barengoltzii]
6TSB_AAA 2.67e-52 32 331 37 346
ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
6T9M_AAA 4.28e-52 32 331 56 365
ChainAAA, Peroxiredoxin [Clostridioides difficile 630]
3QOK_A 9.55e-52 45 335 50 416
ChainA, Putative chitinase II [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
6HM1_A 2.24e-51 45 338 27 396
Structuraland thermodynamic signatures of ligand binding to an enigmatic chitinase-D from Serratia proteamaculans [Serratia proteamaculans 568]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
P20533 7.05e-43 32 321 46 438
Chitinase A1 OS=Niallia circulans OX=1397 GN=chiA1 PE=1 SV=1
P11797 1.27e-35 35 327 21 414
Chitinase B OS=Serratia marcescens OX=615 GN=chiB PE=1 SV=1
Q13231 6.32e-32 27 316 20 358
Chitotriosidase-1 OS=Homo sapiens OX=9606 GN=CHIT1 PE=1 SV=1
P36222 1.54e-31 8 325 11 361
Chitinase-3-like protein 1 OS=Homo sapiens OX=9606 GN=CHI3L1 PE=1 SV=2
P32470 2.18e-31 50 335 85 398
Chitinase 1 OS=Aphanocladium album OX=12942 GN=CHI1 PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

0.000387 0.542289 0.456766 0.000178 0.000184 0.000165

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002717_00851.