CAZyme Information: MGYG000002784_01062

Basic Information

• Species: Porphyromonas sp900538385
• Lineage: Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae; Porphyromonas; Porphyromonas sp900538385
• CAZyme ID: MGYG000002784_01062
• CAZy Family: GT19
• CAZyme Description: Lipid-A-disaccharide synthase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
378		41984.62	9.5252

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002784	2012007	MAG	United States	North America

• Gene Location: Start: 446; End: 1582 Strand: -

Full Sequence      

MKYLLIAGEASGDEHGARLIASLKAVDAKAAFSFIGGDKMAHQAGVAPLYHYREIAVMGF
TSVLRSMRKIRRAARLLQEEMRSNPPDVVIPIDYGGFNLRYTLPMVHRHGVPVVYYIPPK
VWASRRRRIKRLRSYTDLCLTILPFEADYLSQRGVNARYVGNPSIQSVGELLDGNAKLCD
TARPYIALLPGSREAEIARNLPIMCRAIDRLPAPWRAVIAGAPSIDPAHYSPYLSERIEL
VIDETLPLLAGASAALVTSGTATLETALIGTPQVVAYRLPAGRMARWAFDHLLPIRYFSL
VNLIAESPVVEELLGDAVTAQRLVQALTPLLDRESKAYQMQQAQYSMVRQRLDPSRVASQ
VAAERIYHALTTQWEPND

Enzyme Prediction     

No EC number prediction in MGYG000002784_01062.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT19	4	351	4.5e-98	0.9858757062146892

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK00025	lpxB	2.18e-88	1	364	2	373	lipid-A-disaccharide synthase; Reviewed
COG0763	LpxB	6.02e-84	1	366	2	375	Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis].
pfam02684	LpxB	3.16e-68	4	364	2	373	Lipid-A-disaccharide synthetase. This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyze the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyze the fist disaccharide step in the synthesis of lipid-A-disaccharide.
TIGR00215	lpxB	1.00e-57	4	363	9	380	lipid-A-disaccharide synthase. Lipid-A precursor biosynthesis producing lipid A disaccharide in a condensation reaction. transcribed as part of an operon including lpxA [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
PRK14089	PRK14089	2.52e-43	1	326	2	312	lipid-A-disaccharide synthase.

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AEE12174.1	2.09e-248	1	378	1	378
SQH73726.1	1.74e-101	1	366	1	372
QUB42945.1	2.40e-97	1	362	1	364
ATS09476.1	3.58e-93	1	362	1	366
ATS02318.1	7.16e-93	1	362	1	366

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5W8N_A	4.88e-35	5	340	11	354	LipidA Disaccharide Synthase (LpxB)-6 solubilizing mutations [Escherichia coli BL21(DE3)]
5W8S_A	4.88e-35	5	340	11	354	LipidA Disaccharide Synthase (LpxB)-7 solubilizing mutations [Escherichia coli BL21(DE3)],5W8X_A Lipid A Disaccharide Synthase (LpxB)-7 solubilizing mutations-Bound to UDP [Escherichia coli BL21(DE3)]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q1D393	9.18e-55	2	325	6	335	Lipid-A-disaccharide synthase OS=Myxococcus xanthus (strain DK1622) OX=246197 GN=lpxB PE=3 SV=1
Q6ALW0	3.84e-54	4	331	13	350	Lipid-A-disaccharide synthase OS=Desulfotalea psychrophila (strain LSv54 / DSM 12343) OX=177439 GN=lpxB PE=3 SV=1
A9KC41	5.51e-50	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain Dugway 5J108-111) OX=434922 GN=lpxB PE=3 SV=1
B6J161	5.51e-50	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuG_Q212) OX=434923 GN=lpxB PE=3 SV=1
B6J9H1	5.51e-50	4	335	7	341	Lipid-A-disaccharide synthase OS=Coxiella burnetii (strain CbuK_Q154) OX=434924 GN=lpxB PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000077	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002784_01062.