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CAZyme Information: MGYG000002827_02180
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Phyllobacterium sp900539805 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales_A; Rhizobiaceae_A; Phyllobacterium; Phyllobacterium sp900539805 | |||||||||||
| CAZyme ID | MGYG000002827_02180 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Acetyl-coenzyme A synthetase | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 88643; End: 90595 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| TIGR02188 | Ac_CoA_lig_AcsA | 0.0 | 17 | 644 | 1 | 626 | acetate--CoA ligase. This model describes acetate-CoA ligase (EC 6.2.1.1), also called acetyl-CoA synthetase and acetyl-activating enzyme. It catalyzes the reaction ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA and belongs to the family of AMP-binding enzymes described by pfam00501. |
| cd05968 | AACS_like | 0.0 | 21 | 635 | 7 | 610 | Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase. This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. |
| PRK04319 | PRK04319 | 0.0 | 64 | 634 | 33 | 570 | acetyl-CoA synthetase; Provisional |
| cd05967 | PrpE | 0.0 | 23 | 641 | 1 | 617 | Propionyl-CoA synthetase (PrpE). EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency. |
| PRK00174 | PRK00174 | 0.0 | 5 | 649 | 1 | 637 | acetyl-CoA synthetase; Provisional |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| CAE6201330.1 | 1.62e-262 | 2 | 643 | 561 | 1211 |
| CAE6201338.1 | 2.24e-262 | 2 | 643 | 572 | 1222 |
| CAE6256584.1 | 3.52e-21 | 252 | 618 | 1705 | 2058 |
| AFY93865.1 | 1.17e-18 | 72 | 624 | 329 | 851 |
| AFZ04852.1 | 1.19e-14 | 69 | 615 | 579 | 1074 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 2P2Q_A | 0.0 | 17 | 646 | 18 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2Q_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2J_A | 0.0 | 17 | 646 | 18 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2J_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 2P2M_A | 0.0 | 17 | 646 | 18 | 646 | ChainA, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium],2P2M_B Chain B, Acetyl-coenzyme A synthetase [Salmonella enterica subsp. enterica serovar Typhimurium] |
| 1PG3_A | 0.0 | 17 | 646 | 18 | 646 | ChainA, acetyl-CoA synthetase [Salmonella enterica],1PG3_B Chain B, acetyl-CoA synthetase [Salmonella enterica],1PG4_A Chain A, acetyl-CoA synthetase [Salmonella enterica],1PG4_B Chain B, acetyl-CoA synthetase [Salmonella enterica] |
| 5JRH_A | 0.0 | 17 | 646 | 18 | 646 | Crystalstructure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2],5JRH_B Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q2YLH5 | 0.0 | 1 | 649 | 1 | 651 | Acetyl-coenzyme A synthetase OS=Brucella abortus (strain 2308) OX=359391 GN=acsA PE=3 SV=1 |
| Q6G1W0 | 0.0 | 1 | 649 | 1 | 649 | Acetyl-coenzyme A synthetase OS=Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) OX=283166 GN=acsA PE=3 SV=1 |
| Q6FYL4 | 0.0 | 1 | 647 | 1 | 647 | Acetyl-coenzyme A synthetase OS=Bartonella quintana (strain Toulouse) OX=283165 GN=acsA PE=3 SV=1 |
| Q57B76 | 0.0 | 1 | 649 | 1 | 651 | Acetyl-coenzyme A synthetase OS=Brucella abortus biovar 1 (strain 9-941) OX=262698 GN=acsA PE=3 SV=1 |
| Q8FYQ3 | 0.0 | 1 | 649 | 1 | 651 | Acetyl-coenzyme A synthetase OS=Brucella suis biovar 1 (strain 1330) OX=204722 GN=acsA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000049 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |