dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002827_02677

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Basic Information help

Species

Phyllobacterium sp900539805

Lineage

Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales_A; Rhizobiaceae_A; Phyllobacterium; Phyllobacterium sp900539805

CAZyme ID

MGYG000002827_02677

CAZy Family

GH23

CAZyme Description

Membrane-bound lytic murein transglycosylase F

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
482	MGYG000002827_19\|CGC2	53727.46	6.9898

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002827	5102924	MAG	Singapore	Asia

Gene Location

Start: 65544; End: 66992 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002827_02677.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH23	324	462	7.2e-22	0.7925925925925926

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd13403	MLTF-like	6.67e-62	311	461	1	159	membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins. This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.
cd01009	PBP2_YfhD_N	4.23e-58	47	287	1	223	The solute binding domain of YfhD proteins, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes the solute binding domain YfhD_N. These domains are found in the YfhD proteins that are predicted to function as lytic transglycosylases that cleave the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamin in peptidoglycan, while the YfhD_N domain might act as an auxiliary or regulatory subunit. In addition to periplasmic solute binding domain, they have an SLT domain, typically found in soluble lytic transglycosylases, and a C-terminal low complexity domain. The YfhD proteins might have been recruited to create localized cell wall openings required for transport of large substrates such as DNA. They belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.
COG4623	MltF	4.81e-54	39	472	15	445	Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms].
PRK10859	PRK10859	9.42e-48	7	458	6	447	membrane-bound lytic murein transglycosylase MltF.
cd00254	LT-like	4.45e-25	324	458	3	110	lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ATU90426.1	1.62e-259	11	482	12	485
QRM54422.1	9.99e-216	30	477	34	481
QSZ23010.1	1.44e-213	36	466	40	470
ANK75328.1	3.79e-208	7	466	1	465
QHG73581.1	3.09e-207	7	466	1	465

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
4ZV1_A	4.06e-10	63	183	28	138	Anancestral arginine-binding protein bound to arginine [synthetic construct],4ZV2_A An ancestral arginine-binding protein bound to glutamine [synthetic construct]
5TUJ_C	2.70e-08	40	285	5	234	AncestralCationic Amino Acid Solute Binding Protein (AncCDT-1) [unidentified]
5T0W_A	3.07e-08	40	285	16	245	Crystalstructure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_B Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_C Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct],5T0W_D Crystal structure of the ancestral amino acid-binding protein AncCDT-1, a precursor of cyclohexadienyl dehydratase [synthetic construct]
6FBT_A	2.99e-07	331	461	473	592	ChainA, Lytic murein transglycosylase [Pseudomonas aeruginosa]
5OHU_A	3.06e-07	331	461	502	621	TheX-ray Structure of Lytic Transglycosylase Slt from Pseudomonas aeruginosa [Pseudomonas aeruginosa]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A8ZWR8	4.29e-31	43	458	37	445	Membrane-bound lytic murein transglycosylase F OS=Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3) OX=96561 GN=mltF PE=3 SV=2
Q0VRG6	1.38e-23	40	458	34	447	Membrane-bound lytic murein transglycosylase F OS=Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) OX=393595 GN=mltF PE=3 SV=1
B1KLC4	2.77e-23	52	480	27	472	Membrane-bound lytic murein transglycosylase F OS=Shewanella woodyi (strain ATCC 51908 / MS32) OX=392500 GN=mltF PE=3 SV=1
A8H256	2.96e-22	55	458	42	437	Membrane-bound lytic murein transglycosylase F OS=Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) OX=398579 GN=mltF PE=3 SV=1
Q0HKV0	9.62e-22	49	473	35	452	Membrane-bound lytic murein transglycosylase F OS=Shewanella sp. (strain MR-4) OX=60480 GN=mltF PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000391	0.997658	0.001362	0.000211	0.000187	0.000171

TMHMM Annotations download full data without filtering help

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