CAZyme Information: MGYG000002873_00335

Basic Information

• Species: CAG-495 sp900538765
• Lineage: Bacteria; Proteobacteria; Alphaproteobacteria; RF32; CAG-239; CAG-495; CAG-495 sp900538765
• CAZyme ID: MGYG000002873_00335
• CAZy Family: GT51
• CAZyme Description: Penicillin-binding protein 1C

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
758	MGYG000002873_3|CGC1	84092.62	8.654

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002873	1867269	MAG	United States	North America

• Gene Location: Start: 11455; End: 13731 Strand: +

Full Sequence      

MLGGVLLGLVFCLLVPKPVLYEKYSFSSAVYDRQDHLLKLSLSMDDKYRLFVPFEKIPSE
AVQALLLYEDRSFYYHPGVNPLSILRAVAEMAGGGRRQGASTITMQLARIIYNIDSSKVS
GKIMQILRALQIEMFYSKDEILEAYFNLAPYGGNIEGIGAASLIYFNRRAEALYLPQIMA
LTVIPQNPGKRALLTANGRKSVAAASARLKKIWQKTYSHPENSYLSLPLSSGVYLPREAP
HFTRSVLEKNSGEVKTVLDLNYQHMAEEILHNYVREHRRQGVYNAAALIVDARTMDVLAY
VGSQNFWDDTIRGQVDGAGALRSPGSVLKPFIYALALQQGIIHPMTMLKDVPKNYGVYTP
ENFDHSFYGLVNATQALVYSRNIPAVELLLRVGENNFYNLLQESGVPDLRPVEFYGLAMA
LGGTEVSMRNLAAMYAMLYNQGKFKPLRFLGEEQGEEKCLLSPEAAFLTLNMLSKNMAVD
DSRTRFSASKNAYPVAWKTGTSYGYKDAWSAGVVGPYVVVVWIGNFDGTPNNAFVGRDIA
APLFFRLVRRLARENNIPPRLEPSSDLKLAKVSICRDTGDLAGSGCKDRVVSYFIPGVSD
IKLSNISRQIPIDVETGLRACRHAPPSTVMKSYNFWPSDVLRAYAEAGISISRPPAFKED
CSEVETYSQGRAPEIVMPVAGSRFLLRSANLENEKIVLKASLDADAEYAYWFVNNRLAGQ
TKAGETLEVSPPLGNAEVKAVDNMGRASSVWVEIKLVD

Enzyme Prediction     

No EC number prediction in MGYG000002873_00335.

CAZyme Signature Domains

Family	Start	End	Evalue	family coverage
GT51	44	195	3e-44	0.8587570621468926

CDD Domains     

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
TIGR02073	PBP_1c	0.0	17	755	1	727	penicillin-binding protein 1C. This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG4953	PbpC	0.0	13	756	23	733	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].
PRK11240	PRK11240	2.30e-111	48	750	61	767	penicillin-binding protein 1C; Provisional
TIGR02074	PBP_1a_fam	3.17e-97	48	544	1	521	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG0744	MrcB	7.83e-97	3	576	27	619	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].

CAZyme Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
AQQ01575.1	1.11e-220	1	757	17	786
ATC86697.1	3.47e-218	6	757	22	792
ABA87803.1	4.13e-216	13	757	20	775
ASQ45895.1	2.39e-215	15	755	26	767
BBO75930.1	2.64e-213	13	757	20	775

PDB Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
5FGZ_A	5.79e-39	37	567	144	706	E.coli PBP1b in complex with FPI-1465 [Escherichia coli K-12],5HL9_A E. coli PBP1b in complex with acyl-ampicillin and moenomycin [Escherichia coli K-12],5HLA_A E. coli PBP1b in complex with acyl-cephalexin and moenomycin [Escherichia coli K-12],5HLB_A E. coli PBP1b in complex with acyl-aztreonam and moenomycin [Escherichia coli K-12],5HLD_A E. coli PBP1b in complex with acyl-CENTA and moenomycin [Escherichia coli K-12],6YN0_A Structure of E. coli PBP1b with a FtsN peptide activating transglycosylase activity [Escherichia coli K-12],7LQ6_A Chain A, Penicillin-binding protein 1B [Escherichia coli K-12]
3VMA_A	6.47e-39	37	567	165	727	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli K-12]
3FWL_A	8.07e-37	43	567	154	710	CrystalStructure of the Full-Length Transglycosylase PBP1b from Escherichia coli [Escherichia coli]
3UDF_A	1.21e-31	47	527	37	689	ChainA, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDF_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDI_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UDX_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE0_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_A Chain A, Penicillin-binding protein 1a [Acinetobacter baumannii],3UE1_B Chain B, Penicillin-binding protein 1a [Acinetobacter baumannii]
3ZG8_B	6.41e-22	131	535	2	441	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]

Swiss-Prot Hits     

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
P76577	2.44e-93	45	750	60	765	Penicillin-binding protein 1C OS=Escherichia coli (strain K12) OX=83333 GN=pbpC PE=1 SV=1
P38050	8.52e-43	52	542	70	586	Penicillin-binding protein 1F OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpF PE=2 SV=2
Q9KUC0	6.16e-41	49	532	180	696	Penicillin-binding protein 1B OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) OX=243277 GN=mrcB PE=3 SV=1
P70997	2.81e-39	19	597	38	650	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
A7FY32	1.94e-38	8	625	33	720	Penicillin-binding protein 1A OS=Clostridium botulinum (strain ATCC 19397 / Type A) OX=441770 GN=pbpA PE=3 SV=1

SignalP and Lipop Annotations

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.205133	0.789784	0.004024	0.000354	0.000301	0.000377

TMHMM  Annotations     

There is no transmembrane helices in MGYG000002873_00335.