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CAZyme Information: MGYG000002895_01387
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Lawsonella clevelandensis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Mycobacteriales; Mycobacteriaceae; Lawsonella; Lawsonella clevelandensis | |||||||||||
| CAZyme ID | MGYG000002895_01387 | |||||||||||
| CAZy Family | GT53 | |||||||||||
| CAZyme Description | putative arabinosyltransferase A | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 32; End: 1531 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GT53 | 3 | 497 | 6.4e-169 | 0.43946615824594853 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam14896 | Arabino_trans_C | 0.0 | 97 | 497 | 1 | 384 | EmbC C-terminal domain. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate. |
| pfam04602 | Arabinose_trans | 6.23e-14 | 3 | 58 | 404 | 459 | Mycobacterial cell wall arabinan synthesis protein. Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| VHO00484.1 | 0.0 | 1 | 499 | 589 | 1087 |
| ALE19641.1 | 0.0 | 1 | 499 | 647 | 1145 |
| ALE34620.1 | 0.0 | 1 | 499 | 610 | 1108 |
| AWH94410.1 | 3.48e-150 | 4 | 493 | 612 | 1099 |
| QGW23374.1 | 9.67e-150 | 4 | 493 | 612 | 1099 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 7BVE_A | 1.78e-115 | 3 | 498 | 614 | 1073 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVE_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbC2-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155] |
| 7BVH_A | 2.94e-115 | 3 | 498 | 627 | 1086 | Crystalstructure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155],7BVH_B Crystal structure of arabinosyltransferase EmbC2-AcpM2 complex from Mycobacterium smegmatis complexed with di-arabinose [Mycolicibacterium smegmatis MC2 155] |
| 7BWR_A | 5.04e-113 | 3 | 498 | 620 | 1080 | Mycobacteriumsmegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BWR_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric 'active state' [Mycolicibacterium smegmatis MC2 155],7BX8_A Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155],7BX8_B Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric 'resting state' [Mycolicibacterium smegmatis MC2 155] |
| 6X0O_A | 6.62e-113 | 3 | 498 | 620 | 1080 | Single-ParticleCryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis [Mycolicibacterium smegmatis MC2 155] |
| 7BVC_B | 6.85e-113 | 3 | 498 | 620 | 1080 | Cryo-EMstructure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol [Mycolicibacterium smegmatis MC2 155],7BVG_B Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose. [Mycolicibacterium smegmatis MC2 155] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q50393 | 8.16e-115 | 3 | 498 | 614 | 1073 | Probable arabinosyltransferase C OS=Mycolicibacterium smegmatis OX=1772 GN=embC PE=3 SV=2 |
| Q50395 | 2.76e-112 | 3 | 498 | 620 | 1080 | Probable arabinosyltransferase B OS=Mycolicibacterium smegmatis OX=1772 GN=embB PE=3 SV=3 |
| Q9CDA9 | 1.54e-110 | 3 | 498 | 618 | 1081 | Probable arabinosyltransferase B OS=Mycobacterium leprae (strain TN) OX=272631 GN=embB PE=3 SV=1 |
| P71485 | 3.25e-110 | 3 | 462 | 624 | 1072 | Probable arabinosyltransferase A OS=Mycobacterium avium OX=1764 GN=embA PE=3 SV=1 |
| Q9CDA8 | 1.29e-109 | 3 | 462 | 623 | 1075 | Probable arabinosyltransferase A OS=Mycobacterium leprae (strain TN) OX=272631 GN=embA PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000033 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
